2022
DOI: 10.1002/ijgo.14366
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Impact of an estrogen replacement regimen on live birth rate in frozen–thawed good‐quality embryo transfer

Abstract: Objective To assess the impact of an estrogen replacement regimen on frozen embryo transfer (FET) cycle outcome. Methods In the present retrospective cohort study, data of infertile women undergoing FET with good‐quality embryos were reviewed. The first group received 2 mg of estradiol hemihydrate (EH) once daily for 6 to 7 days, then twice daily for 4 to 5 days, and then three times a day until embryo transfer. The second group received EH twice daily for 7 to 8 days, then three times a day. The third group r… Show more

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Cited by 5 publications
(5 citation statements)
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References 19 publications
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“…While no study in the literature have evaluated this, step-up estrogen administration may also offer a potential alternative to the late initiation of estrogen therapy (on the 4 th day instead of the 2 nd or 3 rd day of menstruation) to achieve higher levels of LH before progestin initiation. Although a recent study compared two step-up estrogen protocols to a fixed-dose estrogen regimen without desensitization, it did not assess LH levels before progestin initiation and estrogen was started on the 2 nd or 3 rd day of menstruation ( 18 ). Nevertheless, the pregnancy rates were comparable among all three groups.…”
Section: Discussionmentioning
confidence: 99%
“…While no study in the literature have evaluated this, step-up estrogen administration may also offer a potential alternative to the late initiation of estrogen therapy (on the 4 th day instead of the 2 nd or 3 rd day of menstruation) to achieve higher levels of LH before progestin initiation. Although a recent study compared two step-up estrogen protocols to a fixed-dose estrogen regimen without desensitization, it did not assess LH levels before progestin initiation and estrogen was started on the 2 nd or 3 rd day of menstruation ( 18 ). Nevertheless, the pregnancy rates were comparable among all three groups.…”
Section: Discussionmentioning
confidence: 99%
“…The endometrium was prepared with 4 mg daily oral estradiol hemihydrate (Estrofem, Novo Nordisk A/S, Denmark) which commenced on Day 2 of the menstrual cycle. The dosage was adjusted according to the endometrial thickness 19 . Transvaginal ultrasound (Aloka ProSound Alpha 7; Hitachi Healthcare Americas, Inc., Twinsburg, Ohio, USA) was performed to access endometrial thickness.…”
Section: Methodsmentioning
confidence: 99%
“…The results showed that there was no significant difference between the two groups in terms of LBR (oral: 33% vs 32.5%; transdermal: 35.7% vs 32%, respectively) ( 72 ). A more recent retrospective study included 394 cycles and compared three regimens used for estradiol administration: one fixed-dose regimen using 6 mg per day and two step-up regimens (one regimen received 2 mg per day for 6 to 7 days, then 4 mg per day for 4 to 5 days, and 6 mg per day until ET; the other regimen received 4 mg per day for 7 to 8 days, then 6 mg per day until ET) ( 73 ). They found that the step-up regimen starting with 4 mg per day resulted in the greatest endometrial thickness, compared to the step-up regimen using 2 mg per day and the fixed-dose regimen using 6 mg per day (10.2 ± 1.3 mm vs. 9.6 ± 1.4 mm vs. 8.6 ± 0.9 mm; P < 0.001) ( 73 ).…”
Section: Methodsmentioning
confidence: 99%
“…A more recent retrospective study included 394 cycles and compared three regimens used for estradiol administration: one fixed-dose regimen using 6 mg per day and two step-up regimens (one regimen received 2 mg per day for 6 to 7 days, then 4 mg per day for 4 to 5 days, and 6 mg per day until ET; the other regimen received 4 mg per day for 7 to 8 days, then 6 mg per day until ET) ( 73 ). They found that the step-up regimen starting with 4 mg per day resulted in the greatest endometrial thickness, compared to the step-up regimen using 2 mg per day and the fixed-dose regimen using 6 mg per day (10.2 ± 1.3 mm vs. 9.6 ± 1.4 mm vs. 8.6 ± 0.9 mm; P < 0.001) ( 73 ). Furthermore, the reproductive outcomes also favored the 4 mg step-up regimen, with the highest CPR (55.2% vs. 41.1% vs. 42.2%; P <0.035) and highest LBR (50.9% vs. 40.8% vs. 48.1%; P=0.320) ( 73 ).…”
Section: Methodsmentioning
confidence: 99%
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