Impact of antibiotic de-escalation on hospitalized patients with urinary tract infections: A retrospective cohort single center study

Alshareef, Hanan; Alfahad, Wafa; Albaadani, Abeer; Alyazid, Huda; Talib, Ruba Bin

doi:10.1016/j.jiph.2020.03.004

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…Patients have also been shown to experience shorter LOS due to switching from IV to oral treatment (Oberje et al, 2017). These results are in accordance with the findings of two of our included studies, in which LOS was substantially decreased post ASP (Khdour et al, 2018;Alshareef et al, 2020).…”

Section: Discussionsupporting

confidence: 90%

“…A summary of the included studies is provided in Table 1. Eight of the studies (Amer et al, 2013;Al-Tawfiq et al, 2015;Alawi and Darwesh, 2016;Abdallah et al, 2017;Momattin et al, 2018;Al-Omari et al, 2020;Alshareef et al, 2020;Haseeb et al, 2020) were carried out in the Kingdom of Saudi Arabia, including one in a private hospital (Al-Omari et al, 2020), five were conducted in Qatar (Garcell et al, 2016;Garcell et al, 2017;Nasr et al, 2019;Shaukat et al, 2020;Sid Ahmed et al, 2020), two in Lebanon (Chamieh et al, 2019;Moghnieh et al, 2020), two in Jordan (Bhalla et al, 2016;Ababneh et al, 2017), one in Palestine (Khdour et al, 2018), and one in UAE (El-Lababidi et al, 2019). Enani et al (Enani, 2016) conducted a multi-regional study of Gulf Cooperation Council (GCC) countries (Saudi Arabia, Oman, UAE, and Bahrain).…”

Section: Results By Regions and Study Designmentioning

confidence: 99%

“…In recognition of the variability of study designs, different checklists were used to evaluate the quality of the studies, for example the 'Quality Assessment Tool for Before-After (Pre-Post) Studies With No Control Group and Observational Cohort and Cross-Sectional Studies'. Half of the studies (10/20) were crosssectional and cohort studies (Alawi and Darwesh, 2016;Enani, 2016;Garcell et al, 2016;Ababneh et al, 2017;Garcell et al, 2017;Nasr et al, 2019;Alshareef et al, 2020;Haseeb et al, 2020;Moghnieh et al, 2020;Shaukat et al, 2020) and nine studies were pre-post studies (Amer et al, 2013;Al-Tawfiq et al, 2015;Bhalla et al, 2016;Abdallah et al, 2017;Khdour et al, 2018;Chamieh et al, 2019;El-Lababidi et al, 2019;Al-Omari et al, 2020;Sid Ahmed et al, 2020).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…None of the studies included in the systematic review blinded the assessors or measured the confounding variables, except that conducted by Alshareef et al (Alshareef et al, 2020). In three studies out of ten, the measured exposure was not clearly defined or valid among all study participants (Enani, 2016;Ababneh et al, 2017;Haseeb et al, 2020).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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A systematic review of Antimicrobial Stewardship Program implementation in Middle Eastern countries

Ababneh

Nasser

Rababa’h

2021

International Journal of Infectious Diseases

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Background: Antimicrobial resistance is a serious threat to global health. Antimicrobial Stewardship Programs (ASPs) are adopted by healthcare systems worldwide. This review aimed to evaluate the published practices of ASPs in Middle Eastern countries. Methods: Searches were carried out in PubMed/MEDLINE, Embase, EBSCO, Cochrane Library, Google, and Google Scholar electronic databases for studies published from January 2005 to December 2020 that assessed ASP practices in Middle Eastern countries, following PRISMA guidelines. Results: Of the 422 titles identified, 20 studies met the inclusion criteria. Eight studies were conducted in the Kingdom of Saudi Arabia, five in Qatar, two each in Lebanon and Jordan, and one each in Palestine and UAE; there was also one multinational study. Different ASP practices, including prospective auditing and feedback, pre-authorization, tracking, antibiotic restriction, education, de-escalation, and intravenousto-oral switch, were reported. ASP practices correlated with improved susceptibility rates and decreases in antimicrobial use. Conclusion:The outcomes of this review reveal the scarcity of data on ASP practices. The introduction of ASPs in hospitals in Middle Eastern countries has led to favorable clinical effects. Policymakers and stakeholders should promote and invest in implementing these programs as an essential component of their healthcare systems.

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Section: Discussionsupporting

confidence: 90%

Section: Results By Regions and Study Designmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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A systematic review of Antimicrobial Stewardship Program implementation in Middle Eastern countries

Ababneh

Nasser

Rababa’h

2021

International Journal of Infectious Diseases

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“…Alshareef et al (2020) mostraram que o tempo de internação em pacientes que tiveram descalonamento no tratamento com antibiótico foi significativamente menor quando comparado ao grupo de pacientes que não tiveram o tratamento descalonado. No entanto, todos os pacientes foram avaliados quanto à sensibilidade do agente etiológico da doença infecciosa…”

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Consumo de antibióticos em um hospital de alta complexidade: padrão de utilização em diferentes enfermarias

Pereira

Zanetti

Rodrigues

et al. 2022

RSD

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Objetivo: Avaliar o padrão de utilização de antibióticos entre as diferentes enfermarias de um hospital universitário de alta complexidade. Métodos: Estudo descritivo realizado no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Buscou-se no prontuário e prescrição eletrônicos dados clínicos e de medicamentos dos pacientes internados, com 18 anos ou mais, que receberam prescrição de antibiótico no ano de 2014. As prescrições de antibióticos foram classificadas em tratamento empírico (TE) e tratamento direcionado (TD), e seu consumo foi calculado por meio da dose diária definida por 1.000 pacientes-dia, e apresentado por meio do método de Utilização de Medicamentos 90%. Resultados: 4.102 indivíduos tiveram prescrições de antibióticos com finalidade terapêutica. 63.985 (84,6%) prescrições foram classificadas como TE, e 11.660 (15,4%) prescrições foram classificadas como TD. As cefalosporinas de 4ª geração e os glicopeptídeos estão entre aqueles que representaram 90% do consumo em todas as enfermarias. No grupo TD, antibióticos de amplo espectro de ação mantiveram elevado consumo nas unidades, como os carbapenêmicos que foram os mais utilizados em três unidades, e a polimixina mais utilizada na unidade de terapia intensiva. Por outro lado, as penicilinas resistentes à betalactamase passaram a ser representadas em um número maior de enfermarias em relação à TE. Conclusão: O perfil de consumo de antibióticos sugere a hipótese de que os exames de antibiograma estão sendo realizados com o objetivo de investigar o perfil de sensibilidade bacteriana quando há falha terapêutica, e não para descalonar o tratamento.

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The Role of Gram-Negative Bacteria in Urinary Tract Infections: Current Concepts and Therapeutic Options

Behzadi

Urbán

Matuz

et al. 2020

Advances in Experimental Medicine and Biology

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Impact of antibiotic de-escalation on hospitalized patients with urinary tract infections: A retrospective cohort single center study

Cited by 19 publications

References 21 publications

A systematic review of Antimicrobial Stewardship Program implementation in Middle Eastern countries

A systematic review of Antimicrobial Stewardship Program implementation in Middle Eastern countries

Consumo de antibióticos em um hospital de alta complexidade: padrão de utilização em diferentes enfermarias

The Role of Gram-Negative Bacteria in Urinary Tract Infections: Current Concepts and Therapeutic Options

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