2021
DOI: 10.1101/2021.11.02.21265394
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Impact of antibiotics to off-target infant gut microbiota and resistance genes in cohort studies

Abstract: BackgroundYoung children are frequently exposed to antibiotics for otitis media and respiratory infections, with the potential for collateral consequences on the gut microbiome. The impact of antibiotic exposures to off-target microbes (i.e., bacteria not targeted by antibiotic treatment) and antibiotic resistance genes (ARGs) is unknown.MethodsWe used metagenomic sequencing data from paired stool samples collected prior to antibiotic exposure and at 1 year from over 200 infants and a difference-in-differences… Show more

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