Impact of Antioxidants on Pancreatic B-Cell Damage Caused by Streptozotocin in Adult Male Albino Rats

Abstract

Article informationAim of the Work: To evaluate the effect of streptozotocin on the endocrinal functions of the pancreatic gland, and the potential protective effects of vitamin-E in adult male albino rats. Materials and Methods:The Al-Azhar University of Medicine in Cairo's animal house, where this investigation was carried out, between March and May 2022. 50 adult male albino rats were randomly assigned to one of five equal groups: normal control group I, olive oil-treated control group II, vitamin-E-treated control group III, and streptozotocin-treated control group IV and streptozotocin-vitamin E-treated group V.Results: Streptozotocin-treated group [group IV] was connected to significantly higher serum glucose levels, Malondialdehyde [MDA], interleukin-1b, and interleukin-6 levels and decreased level of serum insulin and glutathione [GSH] in comparison to the normal control groups. This was supported by the islets of Langerhans exhibiting areas of necrosis, vacuolation, and deformation of the pancreatic tissue's typical architecture. Lipid peroxidation was significantly reduced in the group that received vitamin E and streptozotocin. [group V] represented by a significant decrease of serum glucose, MDA, interleukin-1b, and interleukin-6 levels. Histopathological changes were improved after receiving vitamin E. Conclusion:In adult male albino rats, streptozotocin-induced changes to the pancreas might be prevented by vitamin E.