Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review

Montaño, Michalina A; Chagomerana, Maganizo; Borok, Margaret; Painschab, Matthew; Uldrick, Thomas S.; Ignacio, Rachel A. Bender

doi:10.1007/s11904-021-00542-5

Cited by 9 publications

(10 citation statements)

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“…A study of NHL patient survival in Uganda identified untreated HIV infection as one of the strongest predictors of mortality, while survival probabilities among HIV‐positive patients receiving antiretroviral therapy were not dissimilar to those of their HIV‐negative counterparts 37 . However, the overall NHL survival, as reported from hospital series from sub‐Saharan African countries remains low, 36,38 due to challenges related both to diagnosis and treatment 32 …”

Section: Discussionmentioning

confidence: 99%

“…This is confirmed by our study results with highest incidence in younger ages and the high NHL mortality observed in parts of sub‐Saharan Africa. By improving the immunological status, combination antiretroviral treatment can allow the HIV positive patients with lymphomas to tolerate standard chemotherapy regimens with similar outcomes to those of the general population 35,36 . A study of NHL patient survival in Uganda identified untreated HIV infection as one of the strongest predictors of mortality, while survival probabilities among HIV‐positive patients receiving antiretroviral therapy were not dissimilar to those of their HIV‐negative counterparts 37 .…”

Section: Discussionmentioning

confidence: 99%

“…By improving the immunological status, combination antiretroviral treatment can allow the HIV positive patients with lymphomas to tolerate standard chemotherapy regimens with similar outcomes to those of the general population. 35,36 A study of NHL patient survival in Uganda identified untreated HIV infection as one of the strongest predictors of mortality, while survival probabilities among HIV-positive patients receiving antiretroviral therapy were not dissimilar to those of their HIV-negative counterparts. 37 However, the overall NHL survival, as reported from hospital series from sub-Saharan African countries remains low, 36,38 due to challenges related both to diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…35,36 A study of NHL patient survival in Uganda identified untreated HIV infection as one of the strongest predictors of mortality, while survival probabilities among HIV-positive patients receiving antiretroviral therapy were not dissimilar to those of their HIV-negative counterparts. 37 However, the overall NHL survival, as reported from hospital series from sub-Saharan African countries remains low, 36,38 due to challenges related both to diagnosis and treatment. 32 Advancements in NHL treatments such as stem cell transplantation, immunotherapy and targeted therapies have markedly improved prognosis in recent years in the highest income countries, regardless of clinical stage, increasing 5-year survival to greater than 70%, although this varies by subtype and age.…”

Section: Discussionmentioning

confidence: 99%

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Global patterns of non‐Hodgkin lymphoma in 2020

Costa

Laversanne

Gospodarowicz

et al. 2022

Intl Journal of Cancer

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We evaluated the global patterns of non-Hodgkin lymphoma (NHL) in 2020 using the estimates of NHL incidence and mortality in 185 countries that are part of the GLO-BOCAN 2020 database, developed by the International Agency for Research on Cancer (IARC). As well as new cases and deaths of NHL, corresponding age-standardized (world) rates (ASR) of incidence and mortality per 100 000 person-years were derived by country and world region. In 2020, an estimated 544 000 new cases of NHL were diagnosed worldwide, and approximately 260 000 people died from the disease. Eastern Asia accounted for a quarter (24.9%) of all cases, followed by Northern America (15.1%) and South-Central Asia (9.7%). Incidence rates were higher in men than in women, with similar geographical patterns. While the incidence rates were highest in Australia and New Zealand, Northern America, Northern Europe and Western Europe (>10/100 000 for both sexes combined), the highest mortality rates (>3/100 000) were found in regions in Africa, Western Asia and Oceania. The large variations and the disproportionately higher mortality in low-and middle-income countries can be related to the underlying prevalence and distribution of risk factors, and to the level of access to diagnostic and treatment facilities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Global patterns of non‐Hodgkin lymphoma in 2020

Costa

Laversanne

Gospodarowicz

et al. 2022

Intl Journal of Cancer

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“…Cancer has become a growing problem, representing a leading cause of morbidity and mortality among people living with HIV. 1 A large number of worldwide studies have shown that HIV infection raises the risk of many non-AIDS defining cancers, including melanoma and non-melanoma skin cancer (NMSC). 2,3…”

Section: Introductionmentioning

confidence: 99%

The association between skin cancer and HIV infection

Martinez¹,

O²,

D’Ácri³

2023

IJDVL

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Background People affected by Human Immunodeficiency Virus (HIV), are burdened by a higher risk of developing malignancies including non-melanoma skin cancer (NMSC) and melanoma skin cancer. Objective To evaluate the association of HIV with melanoma and NMSC at a University Hospital. Methods This is a cross-sectional retrospective study of HIV-infected and a matched comparison group, analyzing the associations between skin cancer and HIV infection. Results Compared to the HIV-uninfected, HIV-infected had 80% association with skin cancer (CI 95%: 1.3-2.4, P = 0.001) The risk was 45-fold higher by patients" age (CI 95%: 3.3-15.9: P = 0.001). When adjusted for patient age, sex and race, the risk was 6.4 fold ligher of having cancer if compared to the others (CI 95%: 49-84, P = 0.001). Melanoma was not found in HIV-infected. Conclusion With this study, we have demonstrated that HIV-infected patients have an increased risk of BCC and SCC. Preventive dermatologic management is pivotal in the care of immunosuppressed patients. These patients must undergo the dermatological examination annually and should receive extensive counseling regarding sun avoidance, use of sunscreens,and sun-protective clothing.

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Impact of HIV infection on access to cancer care and survival among women with invasive cervical cancer in Côte d'Ivoire: A prospective cohort study

Boni

Horo

Didi-Kouko-Coulibaly³

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo assess the impact of HIV on access to invasive cervical cancer (ICC) care and overall survival (OS) in a time of universal access to antiretroviral therapy (ART).MethodsA cohort of women prospectively diagnosed with ICC was consecutively recruited from 2018 to 2020 in public/private cancer centers in Côte d'Ivoire. Follow‐up data were collected through facility‐ and phone‐based approaches. Logistic and Cox regression models allowed analysis of factors associated with access to cancer care and OS, respectively.ResultsOverall, 294 women with ICC aged 50 years (interquartile range [IQR] 43–60) were enrolled, including 21.4% of women living with HIV (WLHIV), 87% being on ART. An advanced ICC clinical stage (III–IV) was less frequent in WLHIV (63.5% vs. 77.1% in HIV‐uninfected women; P = 0.029). Cancer care was initiated in 124 (42.2%) women (54.0% in WLHIV; 39.0% in HIV‐uninfected; P = 0.030). Factors independently associated with access to cancer care were International Federation of Gynecology and Obstetrics (FIGO) stage I–II (adjusted odds ratio [aOR] 3.58, 95% CI 2.01–6.38) and no treatment by traditional healers prior to ICC diagnosis (aOR 3.69, 95% CI 1.96–6.96). The 2‐year OS was 37.9% (95% CI 30.0–47.9). HIV status was not predictive of mortality (adjusted hazard ratio [aHR] 0.98, 95% CI 0.60–1.69). An advanced clinical stage was the only measured predictor of death (aHR 1.59, 95% CI 1.02–2.47).ConclusionIn a time of universal access to ART, HIV infection was not associated with OS among women with ICC in Côte d'Ivoire. Higher access to cancer care in WLHIV might be mediated by enhanced access to ICC screening services, supporting the need to expand these services to other types of healthcare facilities.

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Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review

Cited by 9 publications

References 68 publications

Global patterns of non‐Hodgkin lymphoma in 2020

Global patterns of non‐Hodgkin lymphoma in 2020

The association between skin cancer and HIV infection

Impact of HIV infection on access to cancer care and survival among women with invasive cervical cancer in Côte d'Ivoire: A prospective cohort study

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