Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease

Belitskaya-Lévy, Ilana; Dysken, Maurice W.; Guarino, Peter; Sano, Mary; Asthana, Sanjay; Vertrees, Julia E.; Pallaki, Muralidhar; Llorente, Maria D.; Love, Susan; Schellenberg, Gerard D.

doi:10.1016/j.trci.2018.06.001

Cited by 10 publications

(4 citation statements)

References 25 publications

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“…Previous research has shown a significant interaction between APOE genotype on AD progression with ε4 carriers declining faster than non-carriers following vitamin E and memantine treatment [49]. Possible mechanisms are that APOE may influence AD risk though its role in cholesterol transport, one consideration is that vitamin E and cholesterol share mechanisms of delivery to cells via LDL particles that genotype might influence [18].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Ashley

Bradburn

Murgatroyd

2019

Nutritional Neuroscience

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Findings from observational studies and clinical trials on the associations between vitamin E and dementia remain controversial. Here we conducted a meta-analysis to determine the difference in blood tocopherols levels between patients with Alzheimer's disease (AD) or age-related poor cognitive function and healthy controls. Standardised mean difference (SMD) and 95% confidence intervals (CIs) were calculated and entered into a random effects model. Study quality, heterogeneity and publication bias were also investigated. Thirty-one articles were included in the meta-analysis, which included analyses for α-, β-, γ-and δ-tocopherols. These results indicated that individuals with AD or agerelated cognitive deficits and mild cognitive impairment (MCI) had lower circulatory concentrations of α-tocophenol compared with healthy controls (AD: SMD = −0.97, 95% confidence interval [CI] = −1.27 to −0.68, Z = 6.45, P < 0.00001; age-related cognitive deficits and MCI: SMD = −0.72, 95% CI = −1.12 to −0.32, Z = −3., P < 0.0005). Levels of β-, γ-and δ-tocophenols did not significantly differ between groups of AD and age-related cognitive deficits compared to controls. These results suggest that lower α-tocopherol levels have a strong association with AD and MCI supporting evidence for the role of diet and vitamin E in AD risk and agerelated cognitive decline.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Ashley

Bradburn

Murgatroyd

2019

Nutritional Neuroscience

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“…The apolipoprotein E(APOE) genotype is a known risk factor for AD. Vitamin E administration may help delay cognitive decline by modulating the response to treatment in APOE genotypes ( Belitskaya-Lévy et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Effect of nutrition in Alzheimer’s disease: A systematic review

2023

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Background and objectiveAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by declining cognitive ability. Currently, there are no effective treatments for this condition. However, certain measures, such as nutritional interventions, can slow disease progression. Therefore, the objective of this systematic review was to identify and map the updates of the last 5 years regarding the nutritional status and nutritional interventions associated with AD patients.Study designA systematic review.MethodsA search was conducted for randomized clinical trials, systematic reviews, and meta-analyses investigating the association between nutritional interventions and AD published between 2018 and 2022 in the PubMed, Web of Science, Scopus, and Cochrane Library databases. A total of 38 studies were identified, of which 17 were randomized clinical trials, and 21 were systematic reviews and/or meta-analyses.ResultsThe results show that the western diet pattern is a risk factor for developing AD. In contrast, the Mediterranean diet, ketogenic diet, and supplementation with omega-3 fatty acids and probiotics are protective factors. This effect is significant only in cases of mild-to-moderate AD.ConclusionCertain nutritional interventions may slow the progression of AD and improve cognitive function and quality of life. Further research is required to draw more definitive conclusions.

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“…Nutrients like omega-3, omega-6, PUFA, and MUFA found in nuts, and fish can play most roles in the clearance of Aβ, increase Aβ [ 75 ], phagocytosis [ 76 ], improve behavioral motor function and survival, expression to tau [ 79 ], reduce microglia activities [ 80 ]. vitamin D inhibits induced fibrillar Aβ apoptosis [ 77 ], and vitamin E, APOe4 carrier declined faster with vitamin E association [ 74 ]. EPA and DHA increase the non-amyloidogenic processing of APP [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

Prevention of Alzheimer's disease through diet: An exploratory review

Bhuiyan,

Hasan,

Mahmud

et al. 2023

Metabolism Open

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Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease

Cited by 10 publications

References 25 publications

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer’s disease

Effect of nutrition in Alzheimer’s disease: A systematic review

Prevention of Alzheimer's disease through diet: An exploratory review

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