2010
DOI: 10.1253/circj.cj-10-0283
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Impact of Arterial Load on Left Ventricular Diastolic Function in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease

Abstract: Background:Although left ventricular (LV) diastolic dysfunction is associated with increased risk for incident heart failure in patients with coronary artery disease (CAD), no specific treatment for diastolic abnormalities has been established. Animal and small human studies have shown that an acute increase in LV afterload adversely impacts on LV early diastolic relaxation, but little is known about its chronic effect on diastolic function. Methods and Results:The relationships of various components of arteri… Show more

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Cited by 37 publications
(15 citation statements)
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“…12,22 The E A /E ES ratio does not account for time-varying phenomena during ejection, 12 thus intrinsically neglecting the LV loading sequence (late versus early systolic load), an important determinant of maladaptive remodelling, hypertrophy, diastolic dysfunction and heart failure risk. 22,[24][25][26][27][28][29] Importantly, the commonly made assumption that E A is a lumped parameter of resistive and pulsatile arterial load is incorrect. 12,30-32 E A is not a true elastance (i.e.…”
Section: Limitations Of the Pressure-volume Planementioning
confidence: 99%
“…12,22 The E A /E ES ratio does not account for time-varying phenomena during ejection, 12 thus intrinsically neglecting the LV loading sequence (late versus early systolic load), an important determinant of maladaptive remodelling, hypertrophy, diastolic dysfunction and heart failure risk. 22,[24][25][26][27][28][29] Importantly, the commonly made assumption that E A is a lumped parameter of resistive and pulsatile arterial load is incorrect. 12,30-32 E A is not a true elastance (i.e.…”
Section: Limitations Of the Pressure-volume Planementioning
confidence: 99%
“…Increases in LV end-systolic and arterial elastance occur with aging, particularly in women, and may result in ventricular-vascular stiffening leading to HF with preserved EF (190). Increased PWV and augmentation index are independently associated with systolic and diastolic dysfunction (191)(192)(193). Central PP predicts LV hypertrophy and cardiovascular events (194).…”
Section: Arterial Stiffness Assessmentmentioning
confidence: 99%
“…The LV loading sequence, in particular, which is intrinsically neglected by the pressurevolume paradigm, is an important determinant of maladaptive remodeling, hypertrophy, diastolic dysfunction, and heart failure risk. 1,34,36,37,40,46,47 Our study should be interpreted in the context of its strengths and limitations. Strengths include the large sample size and the high degree of consistency in our findings across different substudies, as well as the assessment of resting arterial load indices and changes in response to a suitable intervention.…”
Section: Discussionmentioning
confidence: 98%