Impact of astaxanthin supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Mokhtari, Elahe; Rafiei, Sahar Chokami; Mashhadi, Nafiseh Shokri; Saneei, Parvane

doi:10.1016/j.jff.2021.104860

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…On the other hand, previous clinical trials, have revealed that oral administration of ASX could reduce hypertension in type 2 diabetic patients (Mashhadi et al, 2018). Similarly, according to a recent metaanalysis, ASX supplementation could reduce DBP in patients from Asian nations, particularly at a dose of ≥12 mg/day supplementation (Mokhtari et al, 2021). These inconsistent results may be attributed to variations in the applied subject and/or administered dose across several research.…”

Section: Resultsmentioning

confidence: 99%

Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple‐blind randomized clinical trial

Jabarpour,

Aleyasin,

Shabani Nashtaei

et al. 2023

Phytotherapy Research

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Astaxanthin (ASX) is a natural carotenoid compound found in several of microorganisms and seafood. It may have numerous therapeutic benefits for polycystic ovarian syndrome (PCOS) patients. The aim of this study was to investigate the effect of ASX on lipid profile, insulin resistance (IR), blood pressure (BP), and oxidative stress (OS) levels in infertile PCOS patients. Overall, 58 infertile women with diagnosed PCOS participated in this triple‐blind randomized clinical trial. They were randomly assigned to two groups, taking either a placebo or ASX (2 × 6 mg/day) for 8 weeks. Blood serum samples were collected from patients before and after the intervention. Fasting Insulin (FI), fasting blood glucose (FBS), OS markers (malondialdehyde [MDA], superoxide dismutase [SOD], and total antioxidant capacity [TAC]), and lipid profiles were evaluated in serum. Moreover, based on the relevant formula, several indices associated with IR were calculated. BP was also assessed at the start and end of the study. After 8 weeks of ASX consumption, a significant reduction was observed in fasting blood sugar, HOMA‐IR, FI, MDA, low‐density lipoprotein‐cholesterol, and TC/HDL‐C. Conversely, ASX significantly increased TAC, HDL‐C, and QUICKI. After adjusting the analysis for the baseline values of age, body mass index, and biochemical parameters, non‐significant values were obtained for QUICKI and FI, along with no changes in other findings. Overall, ASX appears to be an effective and safe supplement that alleviates insulin metabolism, lipid profile parameters, and OS in infertile PCOS patients.

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Section: Resultsmentioning

confidence: 99%

Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple‐blind randomized clinical trial

Jabarpour,

Aleyasin,

Shabani Nashtaei

et al. 2023

Phytotherapy Research

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“…Astaxanthin is a carotenoid (Cao et al., 2021 ) with strong antioxidant capacity, which is widely used in functional foods (Stachowiak & Szulc, 2021 ), aquaculture (Lu & Lu, 2022 ), cosmetics (Cheng et al, 2019 ), and other fields. At present, the research of astaxanthin in the field of functional food mainly focuses on antihypertension (Mokhtari et al., 2021 ), enhancing immunity (Park et al., 2010 ), protecting retina (Otsuka et al., 2013 ), preventing low-density lipoprotein oxidative damage (Visioli & Artaria, 2017 ), etc. Phaffia rhodozyma/Xanthophyllomyces dendrorhous is one of the important sources of natural astaxanthin.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics analysis and fed-batch regulation of high astaxanthin-producing Phaffia rhodozyma/Xanthophyllomyces dendrorhous obtained through adaptive laboratory evolution

Yang

Hong-yuan

et al. 2023

Journal of Industrial Microbiology and Biotechnology

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Astaxanthin has high utilization value in functional food because of its strong antioxidant capacity. However, the astaxanthin content of Phaffia rhodozyma is relatively low. Adaptive laboratory evolution is an excellent method to obtain high-yield strains. TiO2 is a good inducer of oxidative stress. In this study, different concentrations of TiO2 were used to domesticate P. rhodozyma. Results showed that the optimal astaxanthin-producing P. rhodozyma JMU-ALE105 was obtained under domestication with 1000 mg/L TiO2 concentration on the 105th day. After fermentation, the astaxanthin content reached 6.50 mg/g, which was 41.61% higher than that of the original strain. The ALE105 strain was fermented by batch and fed-batch, and the astaxanthin content reached 6.81 mg/g. Transcriptomics analysis showed that astaxanthin synthesis pathway, fatty acid, pyruvate and nitrogen metabolism pathway of ALE105 strain were significantly up-regulated. Based on the nitrogen metabolism pathway, the nitrogen source was adjusted by ammonium sulphate fed-batch fermentation, which increased the astaxanthin content reached 8.36 mg/g. This study provides technical basis and theoretical research for promoting industrialization of astaxanthin production of P. rhodozyma.

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Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Behzadi,

Akbarzadeh,

Mohammadi Sartang

et al. 2024

Nutrition Reviews

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Context Hypertension (HTN) is regarded as a serious public health issue throughout the world. High blood pressure (BP) may be improved by carotenoid supplementation; however, randomized controlled trials (RCTs) provide conflicting evidence. Objective The aim of this study was to evaluate the effects of carotenoid supplementation on BP in RCTs by systematically review and meta-analysis. Data Sources A comprehensive literature search was performed in the Scopus, PubMed, and Web of Science databases until October 2023, with no limitation on the date or language of publication. Data Extraction Studies that evaluated the net effects of carotenoids in the form of supplements on BP in adults were selected. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated on the basis of a fixed or random-effects model. Sensitivity analysis, meta-regression, publication bias, and heterogeneity were assessed using standard methods. Cochrane quality assessments were used to evaluate the included studies' bias risks. Evidence certainty was calculated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework). Data Analysis Reports on a total of 19 RCTs involving 1151 participants were included in this review. Carotenoid supplementation significantly reduced the systolic BP (SBP) (WMD, –2.492 mmHg; 95%CI, –4.52, –0.47; P = 0.016) and diastolic BP (DBP) (WMD, –1.60 mmHg; 95%CI, –2.73, –0.47; P = 0.005). Greater effects were observed in Asian participants, those aged >50 years, nonhealthy participants, and participants with a baseline SBP ≥130 mmHg and DBP ≥80 mmHg, at dose >10 mg. Dose–response analysis showed that carotenoid supplementation decreased SBP and DBP levels at doses of, respectively, 0–25 and 0–20 mg/d. Evidence for all SBP, DBP, and heart rate values was high quality. Conclusions Carotenoid supplementation had a beneficial effect on BP parameters, especially in nonhealthy study participants with high BP baseline levels. PROSPERO registration no CRD42023402740.

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Impact of astaxanthin supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Cited by 5 publications

References 47 publications

Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple‐blind randomized clinical trial

Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple‐blind randomized clinical trial

Transcriptomics analysis and fed-batch regulation of high astaxanthin-producing Phaffia rhodozyma/Xanthophyllomyces dendrorhous obtained through adaptive laboratory evolution

Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials

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