Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm

Abstract

Atorvastatin reduced the risk of major cardiovascular events to a similar relative extent in both older and younger patients with treated hypertension. However, given that event rates were higher in older patients, the absolute benefits of atorvastatin were greater for older than younger patients.

Impact of age and sex on primary preventive treatment for cardiovascular disease in the West Midlands, UK: cross sectional study

“…The MEGA trial found a 33% risk reduction for coronary heart disease with no increase in non-cardiovascular disease mortality or other adverse events, and this effect was independent of age up to 80 8. The ASCOT-LLA trial (in patients aged 40-79) found that statins reduce the risk of cardiovascular disease events and procedures (including fatal and non-fatal stroke),9 and this effect was again independent of age 37. The PROSPER trial, however, showed that while pravastatin given for three years reduced the risk of coronary disease in elderly individuals (aged 70-82), it had no effect on the risk of stroke 38…”

Statins for Primary Prevention of Cardiovascular Disease in Elderly Patients: Systematic Review and Meta-Analysis

“…Fifty-nine RCTs were extracted from these studies, while the updated search for recent RCTs retrieved 387 records. After applying our study inclusion criteria, a total of eight trials [33][34][35][36][37][38][39][40] were eligible for our meta-analysis. Two trials focused on elderly subjects, and six trials comprised subgroup analyses of elderly subjects.…”

<p>The relationship between plasma lipids, oxidant–antioxidant status, and glycated proteins in individuals at risk for atherosclerosis</p>

“…Previous studies have indicated the benefit from lipid lowering, in almost every analysis and for almost every outcome 11,12. In the elderly population, hypercholesterolemia may be the only major CVD risk factor13,14 or one out of several major risk factors 15,16. Lipids tend to change while we age, altering the risk of CVD 17,18.…”