2728 Background 29 With support of the national tuberculosis (TB) program, KHANA has implemented an innovative 30 approach using a seed-and-recruit model to actively find TB cases in the community. The 31 intervention engaged community members including TB survivors to recruit people with TB 32 symptoms in a 'snowball' approach for screening and linkage to treatment. This study aims to 33 explore the acceptability of active case finding with the seed-and-recruit model in detecting new 34 TB cases and determine the characteristics of successful seeds.
36 Methods37 This qualitative study was conducted in four provinces (Banteay Meanchey, Kampong Chhnang, 38 Siem Reap, and Takeo) in Cambodia in 2017. Fifty six in-depth interviews and ten focus group 39 discussions were conducted to gain insights into the acceptability, strengths, and challenges in 40 implementing the model. Transcripts were coded and content analyses were performed.
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Results
43The seed-and-recruit active case finding model was generally well-received by the study 44 participants. They saw the benefits of engaging TB survivors and utilize their social network to 45 find new TB cases in the community. The social embeddedness of the model within the local 46 community was one of the major strengths. The success of the model also hinges on the 47 integration with existing health facilities. Having extensive social network, being motivated, and 48 having good knowledge about TB were important characteristics of successful seeds. Study 49 participants reported challenges in motivating the recruits for screening, logistic capacities, and 50 high workload during implementation. However, there was a general consensus that the model 51 ought to be expanded. 52 53 Conclusions 54 These findings indicate that the seed-and-recruit model should be fine-tuned and scaled up as 55 part of the national TB Program to increase TB new case detection in Cambodia. Further studies 3 56 are needed to more comprehensively evaluate the impacts and cost-effectiveness of the model 57 in Cambodia as well as in other resource-limited settings. 58 59 60 61 Introduction62 Cambodia is one of the 30 countries with a high burden of tuberculosis (TB) [1]. In 2016, the 63 national incidence and prevalence rates of all forms of TB were 345/100,000 population and 64 668/100,000 population, respectively [2]. These rates have reduced substantially since 1990, and 65 a similar decline was observed in the TB mortality rate [2,3]. Cambodia has made notable 66 progress in the fight against TB by achieving a treatment success rate of 94%, one of the highest 67 among the 30 high TB burden countries [4]. However, the successes are impeded by a significant 68 proportion of under-diagnosed cases. Globally, it is estimated that 36% of TB cases were 69 undiagnosed in 2017, and a similar proportion is observed in Cambodia [5][6][7].
70In Cambodia, TB disproportionately affects people living with HIV, household and close 71 contacts of bacteriologically confirmed cases, elderly above the age of 55, ...