Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation　― The Hokuriku-Plus AF Registry ―

Abstract

In a real-world cohort of Japanese NVAF patients, high BNP was significantly associated with TE and death. Plasma BNP might be a useful biomarker for these adverse clinical events.

Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation

“…Interhospital Cardiovascular Studies (Keio Study) (783 patients), 16 and Hokuriku-Plus AF Registry (1492 patients). 11 The data from each registry were collected and integrated in March 2016, and those from the Keio Study were updated in April 2018. A total of 819 patients with valvular AF and 3810 lacking complete data were excluded (Figure; eTable 1 in the Supplement).…”

“…The patient demographic characteristics of each registry have been published previously. 11,[13][14][15][16] Briefly, the J-RHYTHM Registry was a prospective, observational cohort study aiming to determine the current status of anticoagulation therapy in Japanese patients with AF. 13 A total of 7937 patients with AF, with or without warfarin treatment, from 158 institutions throughout Japan were registered between January and July 2009.…”

“…16 The Hokuriku-Plus AF Registry was a prospective, observational cohort study enrolling patients from 19 institutions in the Hokuriku and Yokohama areas of Japan. 11 Patient registration period and definition of risk factors (congestive heart failure, hypertension, diabetes, vascular diseases) in each registry are shown in eTable 2 in the Supplement.…”

“…Several novel risk factors in Japanese patients have been identified in the Fushimi AF, J-RHYTHM, and Hokuriku-Plus AF registries, including persistent or permanent AF, low body weight, anemia, and kidney dysfunction. [7][8][9][10][11] Furthermore, female sex was shown not to be a risk for thromboembolism in the Japanese population. 12 However, these results were obtained from a Japanese registry in which the patient demographic characteristics, especially mean age and risk for thromboembolism, were somewhat different from each other.…”

Stroke and Bleeding Risk Assessments in Patients With Atrial Fibrillation: Concepts and Controversies

“…Their value in a variety of cardiovascular diseases such as myocardial infarction and heart failure have previously been established (80,81). Further studies have also consistently demonstrated that levels of these biomarkers may be used to improve predictions of stroke risk in AF (57,62,(65)(66)(67)71). A RE-LY sub-study found that elevations in troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were common among AF patients (66).…”