Impact of Balloon Inflation Pressure on Cell Viability with Single and Multi Lumen Catheters

Dib, Nabil; Schwalbach, Dillon; Plourde, Brian D.; Kohler, Robert Ε.; Dana, D.; Abraham, John

doi:10.1007/s12265-014-9595-z

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…There, an illustration of the multi-lumen catheter is provided. This catheter is termed the ND ® Infusion Catheter which was also subject to prior published research [36][37][38].…”

Section: Methodsmentioning

confidence: 99%

A New Catheter Technology to Deliver Vascular Stem-Cells

Plourde¹,

Stark²,

Abraham³

2016

Stud Stem Cells Res Ther

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A new device has been designed, developed and tested to improve the capacity of vascular drug and stem cell delivery. The device consists of a catheter with a multitude of small lumens (instead of a large central channel lumen). The use of multiple lumens provides a number of benefi ts to medical intervention. First, the multiple lumens are spread across the catheter cross section. As a consequence, the medication/stem cells are more effectively dispersed into the artery. Second, the construction of the new catheter has an increased mechanical strength compared to the standard single-lumen cathetertherefore, it is able to resist compressive forces caused by a pressurized balloon. This fact makes the new design able to preserve medication/stem cell fl owrates without causing mechanical hemolysis to the cells. Finally, the newly designed device prohibits clumping of stem cells carried in solution.

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“…There, an illustration of the multi-lumen catheter is provided. This catheter is termed the ND ® Infusion Catheter which was also subject to prior published research [36][37][38].…”

Section: Methodsmentioning

confidence: 99%

A New Catheter Technology to Deliver Vascular Stem-Cells

Plourde¹,

Stark²,

Abraham³

2016

Stud Stem Cells Res Ther

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“…We did not consider the effects of the drill bit angle and geometry on the thermal necrosis of the artery wall vascular nerves during the DCP process. In previous studies, thermal stress has been investigated in a rotational atherectomy process, however, it is suggested that future studies should investigate mechanical impact on the blood (hemolysis) during this process [38].…”

Section: Limitationsmentioning

confidence: 99%

Minimizing thermal damage to vascular nerves while drilling of calcified plaque

Gholampour

Hajirayat

2019

BMC Res Notes

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Objective Drilling of calcified plaque (DCP) inside the artery is a method for removing calcified plaques. This study investigated the effect of drill. To validate the maximum temperature calculated by computer simulation, this value was also measured by an experimental on a phantom model. Results Increasing drill bit diameter during drilling would increase the temperature in vascular nerves. In a drill bit with a diameter of 4 mm, the risk of thermal necrosis in vascular nerves of the artery wall decreased by 8.57% by changing the drill from WC to NT. The same value for a drill bit with a diameter of 6 mm was 10.17%. However, the trend of the generated temperature in the vascular nerves did not change significantly with change of the material and diameter of the drill bit. The results showed that for DCP with the least risk of thermal necrosis in vascular nerves and subsequently the lowest risk of restenosis, coagulation and thermal stroke of the patient, the best option is to use a drill bit with a diameter of 4 mm and NT material for drilling.

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“…Dib et al [90] investigated the effect of balloon inflation on the viability of the infused cells, and suggested that multi-lumen catheters are superior. Behfar et al [91] modelled alternative needle designs to the conventional straight or helical needles with an end-hole.…”

Section: Strategies For Improving the Therapeutic Efficacy Of Cell Thmentioning

confidence: 99%

Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

Bruyneel

Sehgal

Malandraki-Miller

et al. 2016

J. of Cardiovasc. Trans. Res.

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When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.

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Impact of Balloon Inflation Pressure on Cell Viability with Single and Multi Lumen Catheters

Cited by 6 publications

References 23 publications

A New Catheter Technology to Deliver Vascular Stem-Cells

A New Catheter Technology to Deliver Vascular Stem-Cells

Minimizing thermal damage to vascular nerves while drilling of calcified plaque

Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

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