Impact of Banff Borderline Acute Rejection Among Renal Allograft Recipients

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“…Its reported frequency varies widely and ranges from 46% to 74% on dysfunctional graft biopsies performed at different time points after transplant. [1][2][3][4][5][6][7][8][9][10] This category is also the most ambiguous from the point of view of treatment strategies for the patient. In fact, this category does not represent a true pathobiological phenomenon.…”

“…In fact, this rate is comparable to what other major transplant centers have reported. [6][7][8][9][10][15][16][17] We used the clinical course of the graft dysfunction for the definitive diagnosis of rejection, and the majority of these cases behaved as early forms of T-cellmediated rejection. More recent molecular tests are being used to fine tune the diagnosis of T-cellmediated rejection and have shown promising results.…”

“…The clinical significance of this lesion has been controversial and is largely determined by the clinical features of the case. [6][7][8][9][10][11][12] Most of the studies on borderline changes have been conducted in deceased donor transplant setups. 3 Mirza Naqi Zafar, depending on the source of the donor organ.…”

Immunologic Concepts in Kidney Transplantation

“…The significance of borderline biopsies on renal outcomes is not clearly defined. One study of 100 kidney allograft biopsies categorized as borderline changes found a progressive increase in serum creatinine over time [38]. Nevertheless, management of a borderline diagnosis has not been clearly defined.…”

Molecular diagnostics identifies risks for graft dysfunction despite borderline histologic changes

“…The incidence of BL histopathology in renal grafts is approximately 20%. [1][2][3][4] Treatment in response to BL findings is still debated, as some studies suggest that BL infiltrates are benign and occur in patients with stable graft function. 5,6 while others suggest that persistence of BL infiltrates may negatively influence graft outcome.…”