Impact of Bariatric Surgery on Carotid Intima-Media Thickness in Patients with Morbid Obesity: a Prospective Study and Review of the Literature

Nabavi, Nima; Ghodsi, Alireza; Rostami, Reyhaneh; Torshizian, Ashkan; Jamialahmadi, Tannaz; Jangjoo, Ali; Nematy, Mohsen; Bahari, Ali; Ebrahimzadeh, Farnoosh; Mahmoudabadi, Elnaz; Khadem‐Rezaiyan, Majid; Rajabzadeh, Farnood; Goshayeshi, Ladan

doi:10.1007/s11695-022-05976-3

Cited by 16 publications

(6 citation statements)

References 33 publications

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“…The prevalence of obesity has increased drastically in recent years not only in adults but also in children, manifesting itself as a global health problem. Obesity has a considerable impact on metabolism, affecting the entire organism [ 1 ] and predisposing to comorbidities such as cancer [ 2 ], hypertension [ 3 ], insulin resistance and diabetes [ 4 ], neurological disorders [ 5 ] and cardiovascular diseases, including heart failure [ 1 ]. At the cardiac level, obesity exponentially increases the risk of heart failure development due to the impact of obesity on the heart [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Martínez‐Martínez

Fernández‐Irigoyen

Santamaría

et al. 2022

IJMS

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A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the mitochondrial antioxidant MitoQ in obese rats. Male Wistar rats were fed a standard diet (3.5% fat; CT) or a high-fat diet (35% fat; HFD) and treated with vehicle or MitoQ (200 μM) in drinking water for 7 weeks. Obesity modulated the expression of 33 proteins as compared with controls of the more than 1000 proteins identified. These include proteins related to endoplasmic reticulum (ER) stress and oxidative stress. Proteomic analyses revealed that HFD animals presented with an increase in cardiac transthyretin (TTR) protein levels, an effect that was prevented by MitoQ treatment in obese animals. This was confirmed by plasma levels, which were associated with those of cardiac levels of both binding immunoglobulin protein (BiP), a marker of ER stress, and fibrosis. TTR stimulated collagen I production and BiP in cardiac fibroblasts. This upregulation was prevented by the presence of MitoQ. In summary, the results suggest a role of TTR in cardiac fibrosis development associated with obesity and the beneficial effects of treatment with mitochondrial antioxidants.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Martínez‐Martínez

Fernández‐Irigoyen

Santamaría

et al. 2022

IJMS

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“…[ 11 ] For the case of gastric cancer, annually 1.1 million new patients are diagnosed, a number that is predicted to increase to 1.8 million annually by 2040. [ 12 ] Maintaining that esophagectomy is the most effective treatment for patients with noninvasive esophageal cancer, [ 13 ] that gastrectomy is the principle treatment for gastric cancer [ 14 , 15 , 16 ] and that bariatric surgery is the only reliable long‐term treatment for extreme obesity, [ 17 , 18 , 19 , 20 ] it is reasonable to conclude that gastric leaks affect a large number of patients, and will continue to do so.…”

Section: Introductionmentioning

confidence: 99%

Surgical Sealant with Integrated Shape‐Morphing Dual Modality Ultrasound and Computed Tomography Sensors for Gastric Leak Detection

et al. 2023

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Postoperative anastomotic leaks are the most feared complications after gastric surgery. For diagnostics clinicians mostly rely on clinical symptoms such as fever and tachycardia, often developing as a result of an already fully developed, i.e., symptomatic, surgical leak. A gastric fluid responsive, dual modality, electronic‐free, leak sensor system integrable into surgical adhesive suture support materials is introduced. Leak sensors contain high atomic number carbonates embedded in a polyacrylamide matrix, that upon exposure to gastric fluid convert into gaseous carbon dioxide (CO2). CO2 bubbles remain entrapped in the hydrogel matrix, leading to a distinctly increased echogenic contrast detectable by a low‐cost and portable ultrasound transducer, while the dissolution of the carbonate species and the resulting diffusion of the cation produces a markedly reduced contrast in computed tomography imaging. The sensing elements can be patterned into a variety of characteristic shapes and can be combined with nonreactive tantalum oxide reference elements, allowing the design of shape‐morphing sensing elements visible to the naked eye as well as artificial intelligence‐assisted automated detection. In summary, shape‐morphing dual modality sensors for the early and robust detection of postoperative complications at deep tissue sites, opening new routes for postoperative patient surveillance using existing hospital infrastructure is reported.

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“…Weight loss has beneficial effects on the main risk factors for ASCVD including elevated total and LDL-cholesterol (LDL-C), triglycerides, and decreased HDL-cholesterol (HDL-C) [6]. Bariatric surgery has beneficial effects on cardiovascular indices [7][8][9]. For instance, it has been shown that gastric bypass surgery improved all lipid profile parameters, although sleeve gastrectomy only improved HDL-C and triglyceride levels [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

BioMed Research International

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Background. Obesity, especially severe obesity, is associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) morbidity and mortality. Bariatric surgery is a durable and effective weight loss therapy for patients with severe obesity and weight-related comorbidities. Elevated plasma levels of lipoprotein (a) (Lp(a)) are causally associated with ASCVD. The aim of this meta-analysis was to analyze whether bariatric surgery is associated with Lp(a) concentrations. Methods. A literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to May 1st, 2021. A random-effects model and the generic inverse variance weighting method were used to compensate for the heterogeneity of studies in terms of study design, treatment duration, and the characteristics of the studied populations. A random-effects metaregression model was used to explore the association with an estimated effect size. Evaluation of funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used to assess the presence of publication bias in the meta-analysis. Results. Meta-analysis of 13 studies including 1551 patients showed a significant decrease of circulating Lp(a) after bariatric surgery (SMD: -0.438, 95% CI: -0.702, -0.174, p < 0.001 , I 2 : 94.05%). The results of the metaregression did not indicate any significant association between the changes in Lp(a) and duration of follow-up after surgery, reduction in body mass index, or baseline Lp(a) concentration. The reduction in circulating Lp(a) was robust in the leave-one-out sensitivity analysis. Conclusion. Bariatric surgery significantly decreases circulating Lp(a) concentrations. This decrease may have a positive effect on ASCVD in obese patients.

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Impact of Bariatric Surgery on Carotid Intima-Media Thickness in Patients with Morbid Obesity: a Prospective Study and Review of the Literature

Cited by 16 publications

References 33 publications

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Surgical Sealant with Integrated Shape‐Morphing Dual Modality Ultrasound and Computed Tomography Sensors for Gastric Leak Detection

The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis

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