Impact of bariatric surgery on subclinical atherosclerosis in patients with morbid obesity

Carmona-Maurici, Júlia; Cuello, Elena; Sánchez, Enric; Miñarro, Antonio; Rius, Ferrán; Bueno, Marta; Fuente, María Cruz de la; Kissler, Jorge Juan Olsina; Vidal, Teresa; María, Virtudes; Betriu, Àngels; Lecube, Albert; Baena‐Fustegueras, Juan Antonio; Peinado-Onsurbe, Júlia; Pardina, Eva

doi:10.1016/j.soard.2020.05.035

Cited by 10 publications

(11 citation statements)

References 39 publications

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“…In most of the included studies, serum ox-LDL was assessed using enzyme-linked immunosorbent assay (ELISA) method. Nine studies used Mercodia ox-LDL kit (Mercodia, Uppsala, Sweden) [ 24 – 28 , 30 , 31 , 33 , 34 ], one study used immunodiagnostic system (Boldon, UK) [ 32 ], and one study used OxiSelect MDA-LDL-Quantitation kit (Cell Biolabs Inc., San Diego, USA) [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low‐Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta‐Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2021

Oxidative Medicine and Cellular Longevity

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Background. Obesity is related to dyslipidemia and increased circulating oxidated LDL (ox-LDL) concentrations that may predispose to atherosclerosis. Bariatric surgery may lower the risk of cardiovascular mortality. Elevated plasma ox-LDL has been associated with atherogenesis and atherosclerotic cardiovascular disease (ASCVD) events. The aim of this meta-analysis was to investigate the impact of bariatric surgery on proatherogenic circulating ox-LDL levels in patients with severe obesity. Methods. Four databases were systematically searched from inception to May 1, 2021. Also, to clarify the heterogeneity of studies with regard to treatment duration, research design, and the demographic features, a random-effects model and the generic inverse variance weighting approach were utilized. To determine the association with the estimated effect size, a random-effect meta-regression approach was performed. Finally, a meta-regression analysis was conducted to explore the influence of, respectively, baseline and changes in body mass index (BMI), baseline ox-LDL, and postsurgery follow-up period with the estimated effect size of surgery on ox-LDL levels. Results. Meta-analysis of 11 studies including 470 subjects showed a significant decline in circulating ox-LDL following bariatric surgery (SMD: -0.971, 95% CI: -1.317, -0.626, p < 0.001 , I 2 : 89.43%). The results of meta-regression did not show any significant association between the changes in ox-LDL after bariatric surgery and baseline BMI, duration of follow-up or baseline ox-LDL values. However, there was a significant association between ox-LDL alteration and percentage of BMI change. Conclusion. Bariatric surgery in patients who had severe obesity causes a decrease of circulating ox-LDL that was apparently dependent in BMI changes.

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Section: Resultsmentioning

confidence: 99%

The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low‐Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta‐Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…This increase in VV density was especially high among subjects with sleep apnea-hypopnea syndrome, reinforcing the role of nocturnal hypoxia in the genesis of atheromatous disease [ 33 ]. It has been also shown that adventitial VV density decreases significantly 6 and 12 months after bariatric surgery [ 13 , 22 ]. However, the present study found no effect on VV density after a 6-month weight-loss intervention with a VLCKD or MedDiet.…”

Section: Discussionmentioning

confidence: 99%

“…However, the present study found no effect on VV density after a 6-month weight-loss intervention with a VLCKD or MedDiet. This lack of effect may be due in part to the short follow-up period, the lower baseline BMI, and the smaller reduction in BMI than occurred in the studies with bariatric surgery [ 13 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Randomized Clinical Trial to Evaluate the Morphological Changes in the Adventitial Vasa Vasorum Density and Biological Markers of Endothelial Dysfunction in Subjects with Moderate Obesity Undergoing a Very Low-Calorie Ketogenic Diet

et al. 2021

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Weight loss after bariatric surgery decreases the earlier expansion of the adventitial vasa vasorum (VV), a biomarker of early atheromatous disease. However, no data are available regarding weight loss achieved by very low calorie ketogenic diets (VLCKD) on VV and lipid-based atherogenic indices. A randomized clinical trial was performed to examine changes in adventitial VV density in 20 patients with moderate obesity who underwent a 6-month very low calorie ketogenic diet (VLCKD, 600–800 kcal/day), and 10 participants with hypocaloric diet based on the Mediterranean Diet (MedDiet, estimated reduction of 500 kcal on the usual intake). Contrast-enhanced carotid ultrasound was used to assess the VV. Body composition analysis was also used. The atherogenic index of plasma (log (triglycerides to high-density lipoprotein cholesterol ratio)) and the triglyceride-glucose index were calculated. Serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. The impact of weight on quality of life-lite (IWQOL-Lite) questionnaire was administered. Participants of intervention groups displayed a similar VV values. Significant improvements of BMI (−5.3 [−6.9 to −3.6] kg/m2, p < 0.001), total body fat (−7.0 [−10.7 to −3.3] %, p = 0.003), and IWQOL-Lite score (−41.4 [−75.2 to −7.6], p = 0.027) were observed in VLCKD group in comparison with MedDiet group. Although after a 6-months follow-up period VV density (mean, right and left sides) did not change significantly in any group, participants in the VLCKD exhibited a significantly decrease both in their atherogenic index of plasma and serum concentration of sICAM-1. A 6-month intervention with VLCKD do not impact in the density of the adventitial VV in subjects with moderate obesity, but induces significant changes in markers of endothelial dysfunction and CV risk.

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“…There are data suggesting the positive impact of bariatric surgery on several cardiometabolic indicators [ 10 , 11 , 12 , 13 , 14 , 15 ]. There have been reports indicating that bariatric surgery might prevent or slow down atherogenesis in the early stages by breaking the vicious circle between inflammation and endothelial dysfunction [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

JCM

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Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or slow atherogenesis by decreasing excessive weight in the early stages of atherogenesis, by suppressing low-grade systemic inflammation as well as by inhibiting oxidative stress and endothelial dysfunction. The aim of this meta-analysis was to provide an answer to whether bariatric surgery has a significant effect on intima-media thickness (IMT) which is a surrogate marker of early atherosclerosis and has a good correlation with atherosclerotic coronary heart disease. Methods: A systematic literature search in PubMed, Scopus, Embase, and Web of Science as well as grey literature was performed from inception to 1 July 2022. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V3 software. Overall, the estimate of effect size was measured by a random effects meta-analysis. To account for the heterogeneity of studies regarding study design, characteristics of the populations, and treatment duration, a random-effects model (using the DerSimonian–Laird method) and the generic inverse variance weighting approach were used. To assess the existence of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. Results: The meta-analysis of 30 trials, including 1488 subjects, demonstrated a significant decrease in IMT after bariatric surgery. The reduction in IMT was also robust in the leave-one-out sensitivity analysis. It must be stressed that the results of the random-effects meta-regression did not suggest any relationship between the changes in IMT and delta body mass index (BMI) or duration of follow-up after the bariatric surgery. However, the subgroup analyses showed a better IMT reduction after laparoscopic sleeve gastrectomy (LSG) when compared to Roux-en-Y gastric bypass (RYGB). Within a year, the IMT follow-up values showed a further improvement. Conclusions: Bariatric surgery significantly reduced IMT. Significant associations were found between the surgery type and IMT changes, as well as a significant effect of follow-up duration on the changes of IMT after bariatric surgery.

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Impact of bariatric surgery on subclinical atherosclerosis in patients with morbid obesity

Cited by 10 publications

References 39 publications

The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low‐Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta‐Analysis

The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low‐Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta‐Analysis

Randomized Clinical Trial to Evaluate the Morphological Changes in the Adventitial Vasa Vasorum Density and Biological Markers of Endothelial Dysfunction in Subjects with Moderate Obesity Undergoing a Very Low-Calorie Ketogenic Diet

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

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