Impact of Bariatric surgery on antimularian hormone in reproductive age women

kabbi, Maha Sahab Al; Al-Taee, Hanan A.; Hussaini, Sabah Kareem Al

doi:10.1016/j.mefs.2018.01.003

Cited by 5 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bariatric surgery often led to a return of regular menstrual cycles ( Rochester et al , 2009 ; Edison et al , 2016 ; Kruchinin et al , 2018 ; Sahab Al Kabbi et al , 2018 ).…”

Section: Resultsmentioning

confidence: 99%

The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis

Snoek

Steegers‐Theunissen

Hazebroek

et al. 2021

Human Reproduction Update

View full text Add to dashboard Cite

BACKGROUND Worldwide, the prevalence of obesity in women of reproductive age is increasing. Bariatric surgery is currently viewed as the most effective, long-term solution for this problem. Preconception bariatric surgery can reduce the prevalence of obesity-related subfertility and adverse maternal, pregnancy and birth outcomes. Maternal health during the periconception period is crucial for optimal gametogenesis and for embryonic and fetal development which also affects health in the later lives of both mother and offspring. Although preconception bariatric surgery improves several pregnancy outcomes, it can also increase the prevalence of pregnancy complications due to excessive and rapid weight loss. This can lead to iatrogenic malnutrition with vitamin deficiencies and derangements in metabolic and endocrine homeostasis. Thus, bariatric surgery can greatly influence periconception maternal health with consequences for reproduction, pregnancy and health in later life. However, its influence on periconception maternal health itself has never been reviewed systematically. OBJECTIVE AND RATIONALE The aim of this review was to investigate associations between bariatric surgery and determinants of periconception maternal health such as endocrine changes, fertility, vitamin status, irregular menstrual cycles, miscarriages and congenital malformations. SEARCH METHODS Medline, Embase, PubMed, Web of Science, Google Scholar and the Cochrane databases were used for the literature search until 1 November 2020. The search strategy terms included, among others, bariatric surgery, hormones, fertility, malformations, miscarriages and vitamin status. We searched for human studies that were written in English. Abstracts, reviews, meta-analyses and conference papers were excluded. The ErasmusAGE score was used to assess the quality of the included studies. OUTCOMES A total of 51 articles were analysed. The mean quality score was 5 (range 2–8). After bariatric surgery, hormonal axes normalized and menstrual cycle regularity was restored, resulting in increased fertility. Overall, there were no short-term risks for reproductive outcomes such as the increased risk of miscarriages or congenital malformations. However, the risk of vitamin deficiencies was generally increased after bariatric surgery. A meta-analysis of 20 studies showed a significant decrease in infertility (risk difference (RD) −0.24, 95% confidence interval (CI) −0.42, −0.05) and menstrual cycle irregularities (RD −0.24, 95% CI −0.34, −0.15) with no difference in rates of miscarriage (RD 0.00, 95% CI −0.09, 0.10) and congenital malformations (RD 0.01, 95% CI −0.02, 0.03). WIDER IMPLICATIONS The current systematic review and meta-analysis show associations between bariatric surgery and periconception maternal health and underlines the need for providing and personalizing preconception care for women after bariatric surgery. We recommend preconception care including the recommendation of postponing pregnancy until weight loss has stabilized, irrespective of the surgery-to-pregnancy interval, and until vitamin status is normalized. Therefore, regular monitoring of vitamin status and vitamin supplementation to restore deficiencies is recommended. Furthermore, this systematic review emphasizes the need for a long-term follow-up research of these women from the periconception period onwards as well as their pregnancies and offspring, to further improve care and outcomes of these mothers and children.

show abstract

“…Bariatric surgery often led to a return of regular menstrual cycles ( Rochester et al , 2009 ; Edison et al , 2016 ; Kruchinin et al , 2018 ; Sahab Al Kabbi et al , 2018 ).…”

Section: Resultsmentioning

confidence: 99%

The effects of bariatric surgery on periconception maternal health: a systematic review and meta-analysis

Snoek

Steegers‐Theunissen

Hazebroek

et al. 2021

Human Reproduction Update

View full text Add to dashboard Cite

show abstract

“…In women without a history of infertility, the AMH level is used to assess the ovarian reserve, or the number of functional oocytes; a high level can be associated with cycle irregularities. Therefore, AMH is increased in patients who suffer from polycystic ovary syndrome (PCOS) and is positively associated with serum levels of testosterone, androstendione, and dehydroepiandrosterone sulfate (DHEAS) [43][44][45][46]. In several pilot surveys, a decrease in AMH concentration after bariatric surgery independent of the surgical procedure was found.…”

Section: Fertilitymentioning

confidence: 99%

“…In several pilot surveys, a decrease in AMH concentration after bariatric surgery independent of the surgical procedure was found. This drop persisted with the exclusion of PCOS patients [43,44,47,48]. The limitations of the current state of research as well as the complex interaction of fertility-promoting and fertility-inhibiting hormonal changes after bariatric surgery must be considered in this context, too.…”

Section: Fertilitymentioning

confidence: 99%

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Jäger

Wolicki

Spohnholz

et al. 2020

IJERPH

View full text Add to dashboard Cite

This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life. For each category, the current status of research is illuminated and implications for bariatric treatment are determined. A summary that includes key messages is given for each subsection. An overall result of this paper is an understanding that sex-specific risks that follow or result from bariatric surgery should be considered more in aftercare. In order to increase the evidence, further research focusing on sex-specific differences in the outcome of bariatric surgery and promising treatment approaches to female-specific diseases is needed. Nevertheless, bariatric surgery shows good potential in the treatment of sex-specific aspects for severely obese women that goes far beyond mere weight loss and reduction of metabolic risks.

show abstract