Impact of being underweight on the long-term outcomes of patients with gastric cancer

Migita, Kazuhiro; Takayama, Tomoyoshi; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Ito, Masahiro; Kunishige, Tomohiro; Nakade, Hiroshi; Nakajima, Yoshiyuki

doi:10.1007/s10120-015-0531-y

Cited by 47 publications

(26 citation statements)

References 27 publications

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“…However, postoperative underweight was a significant risk factor, whereas preoperative underweight was not. This is inconsistent with most previous studies showing that preoperative underweight is a predictor of worse long-term survival (9,10,33). The results reported by Lee and colleagues (34) were consistent with the present finding that postoperative BMI rather than preoperative BMI was an independent prognostic factor for long-term survival.…”

Section: Discussioncontrasting

confidence: 94%

Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

Park

Lee

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Most patients with gastric cancer rapidly lose weight after gastrectomy. Therefore, analysis of the effect of body mass index (BMI) on patients with gastric cancer survival should include postoperative BMI and BMI loss and preoperative BMI. This retrospective cohort study analyzed the effect of three BMI variables and their interaction on long-term outcomes. Preoperative BMI analysis included 2,063 patients with gastric cancer who underwent curative gastrectomy between January 2009 and December 2013 at Seoul National University Bundang Hospital. BMI at postoperative 6 to 12 months was available in 1,845 of these cases. Patients with preoperative BMI 23.0 to <27.5 [HR, 0.63; 95% confidence interval (CI), 0.48-0.82 for BMI 23.0 to <25.0 and HR, 0.57; 95% CI, 0.42-0.78 for BMI 25.0 to <27.5] and postoperative BMI 23.0 to <25.0 (HR, 0.67; 95% CI, 0.46-0.98) showed significantly better overall survival (OS) than pre- and postoperative patients with BMI 18.5 to <23.0, respectively. Postoperative underweight (BMI <18.5; HR, 1.74; 95% CI, 1.27-2.37) and postoperative severe BMI loss (>4.5; HR, 1.79; 95% CI, 1.29-2.50) were associated with higher mortality. Severe BMI loss and preoperative BMI <23.0 had an adverse synergistic effect; patients with BMI <23.0 were more vulnerable to severe BMI loss than those with BMI ≥23.0. Associations with cancer-specific survival were similar. All three BMI variables were prognostic factors for survival of patients with gastric cancer. Preoperative BMI and severe BMI loss had an interaction. Perioperative BMI and weight loss should be analyzed collectively in patients with gastric cancer undergoing gastrectomy. .

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Section: Discussioncontrasting

confidence: 94%

Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

Park

Lee

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…It is presumed that the detrimental effects of obesity may not be evident in the Korean population because Koreans rarely exhibit severe obesity to such an extent that bladder pressure is increased. On the other hand, comorbidities related to being underweight, such as renal disease and tumorous conditions, could have had more influence on OAB in this study [31, 32]. …”

Section: Discussionmentioning

confidence: 98%

Analysis of the prevalence and associated factors of overactive bladder in adult Korean men

2017

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Overactive bladder (OAB) is a prevalent condition characterized by lower urinary tract symptoms (LUTS). Age, education, income, marital status, sleep, and emotional problems have been associated with OAB; however, conflicting results exist. The present study was conducted to estimate the prevalence of OAB and comprehensively analyze its associated factors in a large cross-sectional, population-based study. The data of 94,554 participants aged 19–107 were analyzed from the Korean Community Health Survey (KCHS) of 2012. Data on marital status, physical activity, education level, occupation, body mass index (BMI), income level, sleep time, and stress level were retrieved for all enrolled participants. The overactive bladder symptom score (OABSS) was used to evaluate the presence and degree of OAB. Simple and multiple logistic regression analyses with complex sampling were used for the associations between various factors and the presence of OAB. Overall, OAB was present in approximately 2.9% of the participants. The prevalence of OAB increased with age and steeply increased after 60 years of age (adjusted odds ratio [AOR] for each 10 years = 1.70, 95% confidence interval [CI] = 1.61–1.80, P<0.001). The prevalence of OAB was lower in married than unmarried subjects (AOR = 0.59, 95% CI = 0.48–0.72, P<0.001). The prevalence of OAB was significantly different according to occupation Compared to manager, expert, specialist, clerk group, the prevalence of OAB was highest in unemployed group (AOR = 1.90, 95% CI = 1.55–2.32, P < 0.001). Being underweight was correlated with OAB (AOR = 1.29, 95% CI = 1.08–1.55, P = 0.018). Inadequate sleep showed a significant association with OAB (AOR = 1.13, 95% CI = 1.02–1.25 for ≤6 hours of sleep time and AOR = 1.53, 95% CI = 1.27–1.86 for ≥9 hours of sleep, P<0.001). Stress level showed a dose-dependent positive association with OAB [AOR (95% CI) = 3.91 (3.13–4.89) > 2.16 (1.88–2.48) > 1.39 (1.23–1.57) for severe stress > moderate stress > some stress, respectively, P<0.001]. A medical history of diabetes mellitus, hyperlipidemia, and/or cerebral stroke was significantly related to OAB. Approximately 2.9% of adult Korean men experienced OAB based on the OABSS. Unmarried status; occupation; being underweight; inadequate sleep; stress; and medical history of diabetes mellitus, hyperlipidemia, or cerebral stroke were significantly correlated with OAB.

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“…In gastric cancer patients, the BMI [12], amount of visceral fat [13], and degree of sarcopenia [14], which are indicators of body composition, were demonstrated to be associated with tumor proliferation and prognosis in gastric cancer patients. This study was the first to assess the associations between preoperative CONUT, clinicopathological factors, and survival, and demonstrated the prognostic power of CONUT in gastric cancer patients who underwent curative resection.…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

et al. 2017

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Impact of being underweight on the long-term outcomes of patients with gastric cancer

Cited by 47 publications

References 27 publications

Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

Analysis of the prevalence and associated factors of overactive bladder in adult Korean men

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

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