2020
DOI: 10.1111/tri.13718
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Impact of belatacept conversion on kidney transplant function, histology, and gene expression ‐ a single‐center study

Abstract: Prior studies on belatacept conversion from calcineurin inhibitor (CNI) have been limited by an absence of postconversion surveillance biopsies that could underestimate subclinical rejection, or a case-controlled design. A total of 53 adult patients with allograft dysfunction underwent belatacept conversion (median: 6 months) post-transplant. At a median followup = 2.5 years, patient survival was 94% with a death-censored graft survival of 85%. Seven (13%) patients had acute rejection (including 3 subclinical)… Show more

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Cited by 11 publications
(18 citation statements)
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“…At a median follow-up of 2.5 years, 64 adverse events had occurred during 88.5 p--y of belatacept exposure. Eight (15%) patients required hospitalization at post-conversion due to infection, with urinary-tract infections being the most common indication [ 38 ].…”
Section: Opportunistic Infections (Ois) and Overall Risk Of Infection With Belataceptmentioning
confidence: 99%
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“…At a median follow-up of 2.5 years, 64 adverse events had occurred during 88.5 p--y of belatacept exposure. Eight (15%) patients required hospitalization at post-conversion due to infection, with urinary-tract infections being the most common indication [ 38 ].…”
Section: Opportunistic Infections (Ois) and Overall Risk Of Infection With Belataceptmentioning
confidence: 99%
“…In a review by Yazdi et al, only two of 78 KTx converted from CNI-based to belatacept-based therapy had positive CMV viremia, without signs of infection [ 37 ]. In a study by Gupta et al, six of 53 (11.3%) converted KTx developed CMV-associated disease: of these, three were at high risk for CMV, i.e., the donor was CMV seropositive, the recipient was CMV seronegative, thus putting them at risk for primary CMV infection [ 38 ].…”
Section: Belatacept and Viral Infectionsmentioning
confidence: 99%
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