Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats

Motawi, Tarek K.; Ahmed, Soliman; El-Boghdady, Noha A.; Metwally, Nadia S.; Nasr, Noha N

doi:10.1080/1354750x.2019.1697365

Cited by 33 publications

(22 citation statements)

References 32 publications

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“…The results of the lipid profile of the rats showed significant alterations in the serum total cholesterol across the treated groups ( Table 3). The increase in total cholesterol level in the testosterone group (BPH model) compared to the control and the treatment groups (3 -5) is a clear pointer that, mimicking the life styles of individuals in regards to linking it to BPH may be very correct [14,15]. The increase in cholesterol level could probably be triggered as a result of DCF-Potassium effect on the liver; leading to hepato-biliary impairment as evident by the substantial increase in serum liver enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…The increase in cholesterol level could probably be triggered as a result of DCF-Potassium effect on the liver; leading to hepato-biliary impairment as evident by the substantial increase in serum liver enzymes. This phenomenon would have prevented the transport of triglycerides from the hepatocytes, thus rendering lower amounts of triglycerides, in the serum [15]. Based on the fact that, the liver is the vital tissue of lipid metabolism, drug-induced liver impairment raised total cholesterol levels, while HDL-cholesterol levels decreased alongside those of triglycerides and LDL-cholesterol, respectively [16,12].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the fact that, the liver is the vital tissue of lipid metabolism, drug-induced liver impairment raised total cholesterol levels, while HDL-cholesterol levels decreased alongside those of triglycerides and LDL-cholesterol, respectively [16,12]. This implies that DCF-Potassium interaction with dietary xenobiotics could lead to the generation of ROS and RNS [15] which undoubtedly enhances oxidative stress in several pathophysiological conditions which may include the prostate gland leading to BPH.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Zaruwa¹,

Muhammad²,

Abdullahi³

et al. 2020

SJBR

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Zaruwa¹,

Muhammad²,

Abdullahi³

et al. 2020

SJBR

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“…After extracting betanin from plants other than beetroots, Sutariya & Saraf were able to depict that betanin ameliorated the mRNA and protein expression levels of transforming growth factor-β (TGF-β), as well as, collagen IV in a rat model of streptozotocin-induced diabetic nephropathy [41]. Additionally, betanin has been shown to exhibit hepatoprotective properties against acetaminophen-induced hepatic injury in a rat model, which was confirmed by histopathological data [48]. Moreover, betanin has also been demonstrated to possess antiapoptotic properties [46].…”

Section: Introductionmentioning

confidence: 83%

Betanin: a promising molecule for biomedical applications

2020

Biointerface Res Appl Chem

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Plants with medicinal properties possess beneficial influences on health and disease. Different plant parts and extracts carry valuable active ingredients with pharmacological properties that lead to developing new drugs. Terminalia bellirica is among those plants that have been formulated as pharmaceutical products. This is attributed to its biologically active phenolics and tannins exhibiting analgesic, anti-hypertensive, anti-microbial, anti-diabetic, anti-oxidant, as well as, other pharmacological properties. Beetroot has been shown to be rich in nitrates with a positive impact on the cardiovascular system. Beetroot contains a number of useful ingredients as the free-radical scavenger ascorbic acid, the anti-inflammatory flavonoids and the anti-oxidant carotenoids. Moreover, beetroot is rich in the natural colorant betalains that are further classified into betacyanins and betaxanthins. Betanin, is one of the major constituents of beetroots that have been postulated to possess significant beneficial therapeutic effects in a number of conditions and diseases. However, several studies have demonstrated the relatively poor bioavailability of betanin upon oral administration. In the current review we aim to highlight some of the latest researches dealing with the therapeutic properties of betanin in different disease conditions, the possible mechanistic pathways beyond such beneficial effects and plausible strategies capable of enhancing its stability and bioavailability.

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“…Moreover, improved hepatic redox status and enhanced mitochondrial function were also described in a similar animal model (male Sprague-Dawley rats) that underwent hepatic injury by paraquat administration and received a betanin extract containing 25 or 100 mg betanins for five days (three days before and two days after paraquat administration) [58]. Similarly, reduced lipid peroxidation was observed in rodents exposed to several toxicants (paraquat, paracetamol, diclofenate and carbon tetrachloride) and then treated with betanins, as suggested by the lowered malondialdehyde (MDA) levels found in liver and kidney [59][60][61].…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease

Milton-Laskíbar

Martínéz

Baquedano

2021

Foods

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An increase in the prevalence of noncommunicable chronic diseases has been occurring in recent decades. Among the deaths resulting from these conditions, cardiovascular diseases (CVD) stand out as the main contributors. In this regard, dietary patterns featuring a high content of vegetables and fruits, such as the Mediterranean and the DASH diets, are considered beneficial, and thus have been extensively studied. This has resulted in growing interest in vegetable-derived ingredients and food-supplements that may have potential therapeutic properties. Among these supplements, beetroot juice, which is obtained from the root vegetable Beta vulgaris, has gained much attention. Although a significant part of the interest in beetroot juice is due to its nitrate (NO3−) content, which has demonstrated bioactivity in the cardiovascular system, other ingredients with potential beneficial properties such as polyphenols, pigments and organic acids are also present. In this context, the aim of this review article is to analyze the current knowledge regarding the benefits related to the consumption of beetroot and derived food-supplements. Therefore, this article focuses on nitrate and betalains, which are considered to be the major bioactive compounds present in beetroot, and thus in the derived dietary supplements.

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Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats

Cited by 33 publications

References 32 publications

Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Betanin: a promising molecule for biomedical applications

Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease

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