Impact of Bifrontal Home-Based Transcranial Direct Current Stimulation in Pain Catastrophizing and Disability due to Pain in Fibromyalgia: A Randomized, Double-Blind Sham-Controlled Study

Caumo, Wolnei; Alves, Rael Lopes; Vicuña, Paul; Alves, Camila Fernanda da Silveira; Ramalho, Letícia; Silva, Danton P.; Torres, Iraci Lucena da Silva; Fregni, Felipe

doi:10.1016/j.jpain.2021.11.002

Cited by 36 publications

(42 citation statements)

References 64 publications

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“…Brietzke et al [22] found considerable reductions in pain in individuals with fibromyalgia (n ¼ 20). Nevertheless, while we did not find any significant improvement in physical function as measured by the WOMAC, Caumo et al [23] recorded decrease in disability (n ¼ 48) in women with fibromyalgia. Additionally, after using a doubleblind controlled design, we can confirm that we observed similar results to those obtained in the clinical setting with ideal implementation conditions [24], which provides additional data on the Note.…”

Section: Discussioncontrasting

confidence: 93%

“…Although we followed current tDCS guidelines [ 13 ], they are not specific to OA pain and several parameters need to be examined [ 20 ]. For instance, a longer duration of treatment, longer sessions or higher electrical intensity might be needed to see changes on measures such as WOMAC, as suggested by other studies with different populations obtaining significant results on proxy measures of pain [ 22 , 23 ]. Lastly, we did not measure any biomarkers or assess neuronal mechanisms in this study.…”

Section: Discussionmentioning

confidence: 99%

“…However, this trial was focused on efficacy. These variables will be important for future mechanistic studies on tDCS targeting OA pain [ 22 , 23 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Briefly, a painless electric current is applied to the scalp and is believed to generate analgesic effects by modulating resting membrane potentials of neurons and pain processing pathways in the targeted cortical area [ 21 ]. Recent studies have shown preliminary efficacy in the clinical and home-based settings in patients with fibromyalgia and multiple sclerosis [ 18 , 19 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study

et al. 2022

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…However, this trial was focused on efficacy. These variables will be important for future mechanistic studies on tDCS targeting OA pain [ 22 , 23 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study

et al. 2022

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“…There was no serious adverse event in any of the reviewed studies. Caumo et al (73) Efficacy of repetitive transcranial magnetic stimulation in fibromyalgia: a systematic review and meta-analysis of randomized con-…”

Section: Neurophysiology Clinical Trialsmentioning

confidence: 99%

Fibromyalgia: one year in review 2022

Giorgi

Sirotti

Romano

et al. 2022

Clinical and Experimental Rheumatology

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Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults With Attention-Deficit/Hyperactivity Disorder

et al. 2022

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IMPORTANCETranscranial direct current stimulation (tDCS) may improve symptoms of inattention in adults with attention-deficit/hyperactivity disorder (ADHD). However, previous trials are characterized by small sample sizes, heterogeneous methodologies, and short treatment periods using clinic-based tDCS. OBJECTIVE To determine the efficacy and safety of home-based tDCS in treating inattention symptoms in adult patients with ADHD. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, parallel, sham-controlled clinical trial (tDCS for the Treatment of Inattention Symptoms in Adult Patients With ADHD [TUNED]), conducted from July 2019 through July 2021 in a single-center outpatient academic setting. Of 277 potential participants screened by phone, 150 were assessed for eligibility on site, and 64 were included. Participants were adults with ADHD, inattentive or combined subtype. Exclusion criteria included current stimulant drug treatment, current moderate to severe symptoms of depression or anxiety, diagnosis of bipolar disorder with a manic or depressive episode in the last year, diagnosis of schizophrenia or another psychotic disorder, and diagnosis of autism spectrum disorder; 55 of participants completed follow-up after 4 weeks. INTERVENTIONS Thirty-minute daily sessions of home-based tDCS for 4 weeks, 2 mA anodal-right and cathodal-left prefrontal stimulation with 35-cm 2 carbon electrodes. MAIN OUTCOMES AND MEASURES Inattentive scores in the clinician-administered version of the Adult ADHD Self-report Scale version 1.1 (CASRS-I).RESULTS Included in this trial were 64 participants with ADHD (31 [48%] inattentive presentation and 33 [52%] combined presentation), with a mean (SD) age of 38.3 (9.6) years. Thirty participants (47%) were women and 34 (53%) were men. Fifty-five finished the trial. At week 4, the mean (SD) inattention score, as measured with CASRS-I, was 18.88 (5.79) in the active tDCS group and 23.63 (3.97) in the sham tDCS group. Linear mixed-effects models revealed a statistically significant treatment by time interaction for CASRS-I (β interaction = −3.18; 95% CI, −4.60 to −1.75; P < .001), showing decreased symptoms of inattention in the active tDCS group over the 3 assessments compared to the sham tDCS group. Mild adverse events were more frequent in the active tDCS group, particularly skin redness, headache, and scalp burn. CONCLUSIONS AND RELEVANCEIn this randomized clinical trial, daily treatment with a home-based tDCS device over 4 weeks improved attention in adult patients with ADHD who were not taking stimulant medication. Home-based tDCS could be a nonpharmacological alternative for patients with ADHD.

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Impact of Bifrontal Home-Based Transcranial Direct Current Stimulation in Pain Catastrophizing and Disability due to Pain in Fibromyalgia: A Randomized, Double-Blind Sham-Controlled Study

Cited by 36 publications

References 64 publications

Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study

Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study

Fibromyalgia: one year in review 2022

Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults With Attention-Deficit/Hyperactivity Disorder

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