Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Elnory, Mohamed Anwar; Elmantwe, Ashraf

doi:10.21608/ebwhj.2019.33486

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…A triad-center clinical trial compared the effect of bilateral salpingectomy with a bipolar device and bilateral partial salpingectomy on ovarian reserve in women undergoing cesarean delivery after one year. The results showed no significant differences between the two procedures in terms of hormonal (AMH and FSH) and ultrasonographic (PSV, AFC, VI, FI, ovarian volume, and calculated ovarian age) parameters [66]. In another randomized trial, the measurement of AMH levels before and six-eight weeks postdelivery in women who underwent salpingectomy via monopolar electrosurgery or tubal ligation using the Parkland method during C-section showed no significant difference either within or between groups [67].…”

Section: Ovarian Reservementioning

confidence: 86%

Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer

Zadabedini Masouleh,

Etchegary,

Hodgkinson

et al. 2023

Current Oncology

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Ovarian cancer (OC) is Canada’s third most common gynecological cancer, with an estimated 3000 new cases and 1950 deaths projected in 2022. No effective screening has been found to identify OC, especially the most common subtype, high-grade serous carcinoma (HGSC), at an earlier, curable stage. In patients with hereditary predispositions such as BRCA mutations, the rates of HGSC are significantly elevated, leading to the use of risk-reducing salpingo-oophorectomy as the key preventative intervention. Although surgery has been shown to prevent HGSC in high-risk women, the associated premature menopause has adverse long-term sequelae and mortality due to non-cancer causes. The fact that 75% of HGSCs are sporadic means that most women diagnosed with HGSC will not have had the option to avail of either screening or prevention. Recent research suggests that the fimbrial distal fallopian tube is the most likely origin of HGSC. This has led to the development of a prevention plan for the general population: opportunistic salpingectomy, the removal of both fallopian tubes. This article aims to compile and review the studies evaluating the effect of opportunistic salpingectomy on surgical-related complications, ovarian reserve, cost, and OC incidence when performed along with hysterectomy or instead of tubal ligation in the general population.

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Section: Ovarian Reservementioning

confidence: 86%

Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer

Zadabedini Masouleh,

Etchegary,

Hodgkinson

et al. 2023

Current Oncology

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“…With the pathology data available, it has been demonstrated that up to 70% of ovarian cancers originate from the fallopian tubes. A study conducted in Sweden between 1973 and 2009 demonstrated that 251,465 women who underwent bilateral salpingo-oophorectomy for benign reasons during gynecological surgery had a lower risk of ovarian cancer than those who underwent BTL [24]. In the study, which lasted for about 14 years and had a considerably high number of cases (1,132,914 patients), TS was performed in 264,048 patients.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ömeroğlu,

Ünlü,

Uğur Kılınç

et al. 2023

Medicina

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Background and Objectives: To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in the bilateral tubal ligation (BTL) materials used during cesarean section (S/C). Materials and Methods: In total, 138 patients underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients’ data were obtained from the hospital’s system. All data and findings were investigated and statistically evaluated. Results: The mean age was 34.62 years (22–44), the mean gravity was 4.89 (2–15) and the mean parity was 3.46 (1–10). In total, 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between the epithelial cell lineage and age between Ki-67, SCOUT, and gravity; between the Ki-67 results and gravity and parity; and between the p53 score and age. Conclusions: TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.

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Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ömeroğlu,

Ünlü,

Uğur Kılınç

et al. 2023

Preprint

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Abstract Objectives To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in bilateral tubal ligation (BTL) materials performed during cesarean section (S/C). Materials and Methods 138 patients who underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients’ data were obtained from the haospital’s system. All data andd findings were investigated and statistically evaluated. Results The mean age was 34.62 years (22 - 44), the mean gravity was 4.89 (2-15) and the mean parity was 3.46 (1-10). 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between epithelial cell lineage and age and between KI-67, SCOUT, and gravity, between KI-67 results and gravity and parity, and between P53 score and age. Conclusion TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/ Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.

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Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Cited by 4 publications

References 35 publications

Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer

Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

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