Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats

Adedara, Isaac A.; Abiola, Michael Abayomi; Adegbosin, Adedayo N.; Odunewu, Ajibola A.; Farombi, Ebenezer O.

doi:10.1016/j.chemosphere.2019.124501

Cited by 16 publications

(4 citation statements)

References 51 publications

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“…Se and Zn supplementation in the present study decreased the levels of Pb, Hg, Al and Mn in the ovary and thyroid with evidence of higher levels of fecal elimination of these toxic metals and improved histoarchitecture which tended to agree with the findings of previous workers on the histoprotective effects of Se and Zn on heavy metal exposed thyroid gland of female rats ( Salah et al 2022 ). Zn upregulates the activation of antioxidant transcription factors and the expression of genes for antioxidants and has been found to counteract oxidative stress in heavy metal-exposed rats ( Samir et al, 2012 , Adedara et al, 2019 ). Similarly, heavy metal mediated histopathological alterations which have been attenuated by Se and Zn administration were probably due to their antioxidant properties ( Mohamed et al, 2016 , Hassanin et al, 2013 ).…”

Section: Resultsmentioning

confidence: 99%

Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

Eddie-Amadi¹,

Ezejiofor²,

Orish³

et al. 2023

Current Research in Toxicology

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Section: Resultsmentioning

confidence: 99%

Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

Eddie-Amadi¹,

Ezejiofor²,

Orish³

et al. 2023

Current Research in Toxicology

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“…Firstly, in the hypothalamus, nickel exposure harms neurological function. As a result, hypothalamic neurons degenerate, paraventricular and supraoptic nuclei are reduced, and myeloperoxidase activity, nitric oxide increase, tumor necrosis factor-α and interleukin-1β of factors that promote inflammation ascend, which will affect the endocrine axis and might lead to hormonal imbalances (42,43); Secondly, there is the possibility that nickel can affect the hypothalamic-pituitary-thyroid axis, causing abnormal thyroid activity (44). Finally, nickel disrupts the function of insulin β cells, resulting in abnormal glucose and lipid metabolism and affecting body weight (45,46).…”

Section: Discussionmentioning

confidence: 99%

Association between urinary nickel with obesity status in adults: A cross-sectional study

Wang

Huang²,

Li³

et al. 2023

Front. Public Health

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ObjectivesThe prevalence of obesity is on the rise and is connected to numerous factors. However, the relationship between obesity and nickel has never been investigated. Our study aimed to explore the association between urinary nickel and obesity Status in adults.MethodsFrom the 2017–2018 National Health and Nutrition Examination Surveys (NHANES), 1,705 participants ≥18 years of age were enrolled. To explore further the relationship among urinary nickel, body mass index (BMI), and waist circumference(WC), Weighted multivariate linear regression analyses and further subgroup analyzes were conducted.ResultsUrinary nickel does not correlate with BMI level but positively correlates with WC. In the subgroup analyzed according to sex, Urinary nickel has a positive correlation with BMI and WC in males but has a negative correlation in females. Secondary stratification analysis according to sex and race, Urinary nickel positively correlates with BMI in White males. It also positively correlates with WC in both White and Black males.ConclusionsA correlation was found between urinary nickel levels and BMI and WC in adult males. Adult men, especially those already obese, may need to reduce nickel exposure.

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“…A limiting factor to the use of selenium is its bioavailability and toxicity, for example, selenium can be metabolized into hydrogen selenide, a very toxic form of selenium 16 . Nanoparticles have a relatively small size and high surface area that increases their chemical activity and makes them efficient catalysts 17 .…”

Section: Introductionmentioning

confidence: 99%

Effects of sodium selenite, cysteamine, bacterially synthesized Se-NPs, and cysteamine loaded on Se-NPs on ram sperm cryopreservation

Salimi,

Hajarian,

Karamishabankareh

et al. 2024

Sci Rep

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During the cryopreservation of sperm, the production of highly reactive oxygen species (ROS) can reduce their viability and fertility. However, the addition of antioxidants can help reduce the harmful effects of ROS. One such antioxidant is selenium, which is a co-factor of the glutathione peroxidase enzyme that is effective in scavenging ROS. Cysteamine can also take part in the structure of this enzyme. The use of nanoparticles can be less toxic to cells than their salt form. To this end, researchers synthesized Se-NPs using the streptococcus bacteria and loaded cysteamine onto the synthesized Se-NPs. The biosynthesis of Se-NPs and cysteamine loaded on Se-NPs was confirmed by UV–visible spectroscopy, X-ray diffraction (EDX), Fourier transforms infrared (FTIR) spectroscopy, and Field Emission Scanning Electron Microscope (FE-SEM). For cryopreservation, ram semen samples were diluted, and different concentrations (0, 1, 5, 25, and 125 µg/mL) of cysteamine, Se-NPs, cysteamine loaded on Se-NPs, and sodium selenite were added. An extender containing no supplement was considered as control group. After cooling the semen samples, they were frozen and stored in liquid nitrogen for evaluation. The samples were thawed and analyzed for mobility, viability, membrane and DNA integrity, and sperm abnormalities, as well as malondialdehyde level (MDA) and superoxide dismutase (SOD). The data was processed using SPSS, and a significance level of p < 0.05 was considered. The results of this experiment showed that adding 1 μg/mL of cysteamine loaded on Se-NPs to the diluent significantly increased the motility, viability, and membrane integrity and SOD of spermatozoa compared to the other treatment groups and control group, and reduced the abnormality, apoptosis, and MDA level of spermatozoa in comparison with the other treatment groups and control group (p < 0.05). In conclusion, the addition of cysteamine loaded on Se-NPs was found to improve the quality of ram sperm after cryopreservation.

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Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats

Cited by 16 publications

References 51 publications

Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats

Association between urinary nickel with obesity status in adults: A cross-sectional study

Effects of sodium selenite, cysteamine, bacterially synthesized Se-NPs, and cysteamine loaded on Se-NPs on ram sperm cryopreservation

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