Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis

Chang, Hye Jin; Lee, Jung Ryeol; Jee, Byung Chul; Suh, Chang Suk; Kim, Seok Hyun

doi:10.1016/j.fertnstert.2008.03.066

Cited by 166 publications

(126 citation statements)

References 53 publications

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“…For both ICSI and IVF, transferring embryos at a later stage of development (days 4-7) result in sex ratios up to 6% higher than after early transfer (days 1-3); this also accords with prior reports (8,10,30,32). It is also notable that single embryo transfer at the blastocyst stage results in significantly higher SSR (RR= 1.056, C.I.…”

Section: Discussionsupporting

confidence: 87%

Effects of assisted reproductive technologies on human sex ratio at birth

Maalouf

Mincheva

Campbell

et al. 2014

Fertility and Sterility

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Section: Discussionsupporting

confidence: 87%

Effects of assisted reproductive technologies on human sex ratio at birth

Maalouf

Mincheva

Campbell

et al. 2014

Fertility and Sterility

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“…Blastocyst culture, as performed in this study, may favor the selection of male embryos for transfer, since they are thought to have greater preimplantation developmental rates [32]. Accordingly, blastocyst transfer has been associated with a sex ratio skewed in favor of male offspring [33]. Our results also revealed a slightly higher male:female ratio in the rHA group, though the ratio was lower in the HSA group.…”

Section: Discussionsupporting

confidence: 48%

Perinatal outcomes for transfer of blastocysts vitrified and warmed in defined solutions with recombinant human albumin: 374 babies born after 898 embryo transfers

Murakami

Egashira

Tanaka

et al. 2014

J Assist Reprod Genet

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Purpose To assess the efficacy of a novel, defined vitrification procedure using recombinant human albumin (rHA) for cryopreservation of human blastocysts. Design: Retrospective study. Setting: Private IVF clinic. Patients: 1,496 patients received vitrified/warmed embryo transfer (ET). Methods Surplus blastocysts, and blastocysts from patients undergoing elective embryo cryopreservation, were vitrified/ warmed using Cryotop carriers in homemade solutions containing either human serum albumin (HSA) or rHA. Main Outcome Measures: Clinical and neonatal outcomes regarding the vitrified/warmed ET procedures. Results The HSA and rHA groups had a total of 1,163 and 898 vitrified/warmed cycles, respectively. Embryo survival rates (98.7 % vs. 98.9 %, respectively) and the number of embryos transferred (1.08±0.01 vs. 1.06±0.01, respectively) were similar in the HSA and rHA groups. Clinical pregnancy rates/ET were higher (P<0.05) in the rHA group (56.0 %) than in the HSA group (51.5 %). The HSA and rHA groups had similar live delivery rates/pregnancy (72.2 % vs. 72.3 %, respectively) and perinatal outcomes, including birth weight (2,988±28 vs. 3,046±26 g, respectively). Birth defects occurred in 0.9 % and 1.6 % of neonates in the HSA and rHA groups, respectively. Conclusions rHA effectively replaced HSA for human embryo vitrification procedures, and yielded high rates of pregnancy and live births after vitrified/warmed ET. This new approach will support the development of defined ART systems, which will eliminate the variation and risks associated with the use of blood-derived products.

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“…They either find more males born after fresh blastocyst transfer compared to spontaneous conception [19] or compared to day 3 transfer [8,17,21], or they show no differences neither in sex ratio nor in growth rate of embryos [9,23,[26][27][28][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Blastocyst transfer and gender: IVF versus ICSI

Hentemann

Briskemyr

Bertheussen

2009

J Assist Reprod Genet

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Purpose To investigate the difference in sex ratio in our centre after day 5 embryo transfer among neonates delivered after fresh in vitro fertilization (IVF), fresh intra cytoplasmatic sperminjection (ICSI) and frozen embryo replacement (FER) compared to expected sex ratio in normal population. Methods Retrospective data after IVF/ICSI/FER therapy from 1995 -2007 and data from the literature on similar subjects. Results Among a total of 420 births after day 5 transfer, there were 225 male and 195 female babies. However, after ICSI alone 30 were female and 21 male. Adding all available data from the literature on gender ratio after long term culture, the ratio of male births to total births (0.545) was significantly (p=0.004) different from the expected ratio (0.515) Conclusions It appears that significantly more males are born than expected after day 5 transfer in IVF. However, a subgroup analysis in our data comparing IVF, ICSI and FER revealed more females born after ICSI and FER, suggesting that further research is needed in this area.

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Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis

Cited by 166 publications

References 53 publications

Effects of assisted reproductive technologies on human sex ratio at birth

Effects of assisted reproductive technologies on human sex ratio at birth

Perinatal outcomes for transfer of blastocysts vitrified and warmed in defined solutions with recombinant human albumin: 374 babies born after 898 embryo transfers

Blastocyst transfer and gender: IVF versus ICSI

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