Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients

Gómez-Martínez, Manuel; Rodríguez-García, Wendy Daniella; González-Islas, Dulce; Orea-Tejeda, Arturo; Salgado-Fernández, Fernanda; Hernández-López, Samantha; Jiménez-Valentín, Angelia; Ríos-Pereda, Alejandra Vanessa; Márquez-Cordero, Juan Carlos; Salvatierra-Escobar, Mariana; López-Vásquez, Iris

doi:10.3390/jcm12041321

Cited by 12 publications

(6 citation statements)

References 46 publications

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“…The research also describes that the phase angle reduces with age regardless of body composition [36]. Gómez-Martínez et al showed PhA < 5.1 • in men and <4.8 • in women was independently associated with mortality in patients with Chronic Obstructive Pulmonary Disease Patients (COPD) [37]. Low phase angle in COPD patients (<4.5 • ) was also associated with lower quadricep strength and quality of life [38].…”

Section: Discussionmentioning

confidence: 99%

Phase Angle, Inflammation, and Sarcopenia in Late Postoperative Roux-En-Y Gastric Bypass

Florêncio,

Souza,

Chaim

et al. 2023

JCM

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Sarcopenic obesity is characterized by a disproportion between the amount of muscle to fat. Contrary to most studies evaluating parameters related to sarcopenic obesity in the elderly, this study aims to evaluate the phase angle (PhA) and sarcopenia in young individuals pre- and post-Roux-en-Y gastric bypass. A total of 69 volunteers (46 women and 23 men; 38.5 ± 8.1 years) participated in this study. Body composition and PhA were assessed using BIA. Sarcopenia was assessed using a handgrip strength test (HGS) and gait speed (GS), and appendicular lean mass (ALM) was assessed using Dual Energy X-ray Absorptiometry (DXA). The PhA was significantly lower (p < 0.0007) and the resistance (R) significantly higher (p = 0.0026) in the postoperative group. HGS was negatively correlated with R (r = −0.63669; p < 0.0001), hs-CRP (r = −0.45436; p = 0.0197), and leptin (r = −0.46505; p = 0.0043). GS was negatively correlated with R (r = −0.36220; p = 0.0254), and ALM was negatively correlated with reactance (r = −0.49485; p = 0.0034) and R (r = −0.65797; p ≤ 0.0001). PhA and other components of BIA provide a good correlation with sarcopenia, especially regarding the reduction in muscle function, in an early form, in individuals in the pre- and postoperative period of gastric bypass.

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Section: Discussionmentioning

confidence: 99%

Phase Angle, Inflammation, and Sarcopenia in Late Postoperative Roux-En-Y Gastric Bypass

Florêncio,

Souza,

Chaim

et al. 2023

JCM

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“…In this study, specific KCL subdomains that demonstrated the strongest correlation with hippocampal volume were identified through questions (1-5), (6)(7)(8)(9)(10), and (16)(17). The first five questions, designated as KCL (1)(2)(3)(4)(5), pertain to instrumental activities of daily living (IADL), assessing the ability to execute daily tasks that demand both cognitive and physical capabilities. Questions (6-10) focus on physical strength and evaluate the individual's muscular and physical endurance.…”

Section: Discussionmentioning

confidence: 99%

“…Each subdomain reached an area under the curve (AUC) of 0.78, indicating reliability. Specifically, achieving a score of 13 or higher or a score of 6 or higher in the KCL overall domain (1-25) and the KCL sub-domain (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), respectively, resulted in a specificity of 93% and a sensitivity of 90%. In the KCL subdomains (1-5) and (6-10), a score of 2 or higher or a score of 3 or more, respectively, resulted in a sensitivity of 80% and a specificity of 87%, and a score of 1 or higher in the KCL subdomain (16)(17) attained 83% specificity in detecting individuals within the lowest quartile.…”

Section: Or Peer Review 5 Of 12mentioning

confidence: 99%

Diagnostic Utility of Specific Frailty Questionnaire: The Kihon Checklist for Hippocampal Atrophy in COPD

Hirano,

Takahashi,

Fukatsu-Chikumoto

et al. 2024

JCM

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Background/Objectives: COPD patients who are frail have been reported to develop brain atrophy, but no non-invasive diagnostic tool has been developed to detect this condition. Our study aimed to explore the diagnostic utility of the Kihon Checklist (KCL), a frailty questionnaire, in assessing hippocampal volume loss in patients with COPD. Methods: We recruited 40 COPD patients and 20 healthy individuals using the KCL to assess frailty across seven structural domains. Hippocampal volumes were obtained from T1-weighted MRI images, and ROC analysis was performed to detect hippocampal atrophy. Results: Our results showed that patients with COPD had significantly greater atrophic left hippocampal volumes than healthy subjects (p < 0.05). The univariate correlation coefficient between the left hippocampal volume and KCL (1–20), which pertains to instrumental and social activities of daily living, was the largest (ρ = −0.54, p < 0.0005) among the KCL subdomains. Additionally, both KCL (1–25) and KCL (1–20) demonstrated useful diagnostic potential (93% specificity and 90% sensitivity, respectively) for identifying individuals in the lowest 25% of the left hippocampal volume (AUC = 0.82). Conclusions: Our study suggests that frailty questionnaires focusing on daily vulnerability, such as the KCL, can effectively detect hippocampal atrophy in COPD patients.

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“…However, there are clear differences in morphofunctional values with a decrease in PhA in the survival vs. non-survival groups (4.85 • vs. 4.27 • p = 0.033) according to BIVA. Gómez-Martínez et al showed that low PhA (5.11 • vs. 4.62 • , p = 0.008) was independently associated with a worse prognosis for COPD patients [33]. Machado et al showed that a quarter of IPF patients with a normal to obese BMI had abnormally low PhA, and patients with IPF classified as low-PhA had worse lung function, exercise capacity, and HRQL [34].…”

Section: Discussionmentioning

confidence: 99%

Rectus Femoris Cross-Sectional Area and Phase Angle asPredictors of 12-Month Mortality in Idiopathic Pulmonary Fibrosis Patients

Fernández-Jiménez,

Cabrera Cesar,

Sánchez García

et al. 2023

Nutrients

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Background: The value of the phase angle (PhA), measured via bioelectrical impedance analysis (BIA), could be considered a good marker of the cell mass and the cell damage of a patient; however, there are new techniques, such as muscle ultrasonography, that allow the quantity and quality of muscle to be assessed in a minimally invasive way. The aim of this study is to determine the prognostic value of morphofunctional techniques in the prognosis of mortality in patients with idiopathic pulmonary fibrosis (IPF). Methods: This multicenter, cross-sectional study included 86 patients with idiopathic pulmonary fibrosis with a mean age of 71 years, 82.7% of whom were male. The nutritional risk of the patients was assessed by means of questionnaires, such as the Subjective Global Assessment (SGA), and non-invasive functional techniques, including BIA, nutritional ultrasound, and hand grip strength (HGS). Statistical analysis of the sample was performed using JAMOVI version 2.3.22. Results: Correlations were made between the RF-CSA techniques with PhA (r = 0.48, p < 0.001), BCM (r = 0.70, p < 0.001), SMI (r = 0.64, p < 0.001), and HGS (r = 0.54, p < 0.001). The cut-off points for 12-month mortality were PhA = 4.5° (AUC = 0.722, sensitivity of 72.7% and specificity of 66.6%), BCM = 28.8 kg (AUC = 0.609, sensitivity of 32.4% and specificity of 100.0%), RF-CSA = 3.00 cm2 (AUC = 0.857, sensitivity of 64.4% and specificity of 100.0%), 6MMW = 420 m (AUC = 0.830, sensitivity of 63.27% and specificity of 100.0%), and TUG = 7.2 s (AUC = 0.771, sensitivity of 100.0% and specificity of 56.67%). In addition, a multivariate analysis was performed with RF-CSA, HR = 8.11 (1.39–47.16, p = 0.020), and PhA of 6.35 (1.29–31.15, p = 0.023), taking into account age, sex, and BMI to determine mortality. Finally, a Kaplan–Meier survival analysis was conducted with low or normal values for classical parameters (GAP and T6MM) and new parameters (PhA, BCM, RF-CSA, and TUG). Conclusion: RF-CSA and PhA were shown to be good prognostic markers of 12-month mortality and could, therefore, be useful screening tools to complement the nutritional assessment of IPF patients.

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Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients

Cited by 12 publications

References 46 publications

Phase Angle, Inflammation, and Sarcopenia in Late Postoperative Roux-En-Y Gastric Bypass

Phase Angle, Inflammation, and Sarcopenia in Late Postoperative Roux-En-Y Gastric Bypass

Diagnostic Utility of Specific Frailty Questionnaire: The Kihon Checklist for Hippocampal Atrophy in COPD

Rectus Femoris Cross-Sectional Area and Phase Angle asPredictors of 12-Month Mortality in Idiopathic Pulmonary Fibrosis Patients

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