Impact of body fat mass extent on cardiac autonomic alterations in women

Sztajzel, Juan; Golay, Alain; Makoundou, Vincent; Lehmann, T; Barthassat, V.; Sievert, K.; Pataky, Zoltan; Assimacopoulos-Jeannet, F.; Bobbioni-Harsch, E

doi:10.1111/j.1365-2362.2009.02158.x

Cited by 47 publications

(47 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, it has been shown that during sodium load, higher SSI is associated with higher HR and lower cardiac vagal modulation, 5 these relationships disappearing when shifting to a low sodium intake. Moreover, insulin resistance was found to be associated both with higher 24-hour HR levels 9 and with higher sodium sensitivity, 6,7 these data further highlighting the existence of a link between elevated HR and sodium sensitivity. In line with our hypothesis, we found a positive correlation between HR 24H and SSI (Table 3).…”

Section: Definition Of Sodium Sensitivity Risk From Map Nf and Hr 24hmentioning

confidence: 53%

“…The HR cutoff was set at 70 bpm on the basis of the reported differences in HR 24H between subjects with and without metabolic syndrome. 9 These classification criteria, based on ABPM data only, allowed us to define 3 subgroups of patients in whom we hypothesize a different degree of sodium sensitivity: a group at low risk for sodium sensitivity (SSLR), including patients classified both as dippers and low HR at 24-hour ABPM; a group at high risk of sodium sensitivity (SSHR), including patients classified both as nondippers and high HR at ABPM; and a group at intermediate sodium sensitivity risk, including patients belonging neither to SSLR nor to SSHR groups because they were classified as dippers and high HR or as nondippers and low HR at ABPM.…”

Section: Classes Of Salt Sensitivity Risk From Abpmmentioning

confidence: 99%

“…5 Changes in both HR and sodium sensitivity have been also described in subjects with metabolic syndrome and insulin resistance. 6 -8 In particular, a 24-hour mean HR Ͼ70 bpm has been reported in a population with elevated body mass index, a condition clearly associated not only with insulin resistance 9 but also with salt sensitivity. All of these findings also contribute to suggest that an elevated 24-hour mean HR might represent a marker of a sodium sensitivity condition.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Detecting Sodium-Sensitivity in Hypertensive Patients

et al. 2011

View full text Add to dashboard Cite

Abstract-Sodium sensitivity is an important cardiovascular risk factor for which a diagnosis requires a time-consuming protocol, the implementation of which is often challenging for patients and physicians. Our aim was to assess the reliability of an easier approach based on data from 24-hour ambulatory blood pressure monitoring performed in hypertensive subjects during daily-life conditions and habitual diet. We enrolled 46 mild to moderate hypertensive subjects who underwent 24-hour ambulatory blood pressure monitoring during usual sodium intake. Patients were divided into 3 classes of sodium sensitivity risk on the basis of ambulatory blood pressure monitoring data: low risk if dippers and a 24-hour heart rate Յ70 bpm; high risk if nondippers and a 24-hour heart rate of Ͼ70 bpm; intermediate risk with the remaining combinations (dippers with heart rate Ͼ70 bpm or nondippers with heart rate Յ70 bpm). Then patients underwent a traditional sodium sensitivity test for the dichotomous classification as sodium sensitive or sodium resistant and for evaluating the sodium sensitivity index. Prevalence of sodium-sensitive patients and mean value of sodium sensitivity index were calculated in the 3 risk classes. The sodium sensitivity index markedly and significantly increased from the low-risk to the high-risk class, being equal to 19.9Ϯ14.4, 37.8Ϯ8.3, and 68.3Ϯ17.0 mm Hg/(mol/ day) in the low-risk, intermediate-risk, and high-risk classes, respectively (MϮSEM). Also, the prevalence of sodium-sensitive patients increased significantly from the low-risk class (25%) to the intermediate-risk (40%) and high-risk (70%) classes. Thus, performance of 24-hour ambulatory blood pressure monitoring in daily-life conditions and habitual diet may give useful information on the sodium sensitivity condition of hypertensive subjects in an easier manner than with the traditional sodium sensitivity test approach. (Hypertension. 2011;57:180-185.)

show abstract

Section: Definition Of Sodium Sensitivity Risk From Map Nf and Hr 24hmentioning

confidence: 53%

Section: Classes Of Salt Sensitivity Risk From Abpmmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Detecting Sodium-Sensitivity in Hypertensive Patients

et al. 2011

View full text Add to dashboard Cite

show abstract

“…These observations were consistent with many others in which subjects with the metabolic syndrome, who are insulin resistant and SS, have increased sympathetic nervous system activity and heart rates. 39,[425][426][427] Another characteristic of many groups of hypertensive patients (eg, secondary hypertension, obstructive sleep apnea, chronic renal insufficiency) is a diminished sleep-associated reduction in BP (nondipping of BP), which is known to have detrimental prognostic implications. Subjects with features of the SS hypertensive phenotype such as the metabolic syndrome also have a high prevalence of nondipping.…”

Section: Surrogate Markers Of Ssbp In Humansmentioning

confidence: 99%

Salt Sensitivity of Blood Pressure

Elijovich¹,

Weinberger²,

Anderson³

et al. 2016

Hypertension

386

230

View full text Add to dashboard Cite

The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 23, 2016, and the American Heart Association Executive Committee on February 23, 2016. A copy of the document is available at http://professional.heart.org/statements by using either "Search for Guidelines & Statements" or the "Browse by Topic" area. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@ wolterskluwer.com.The American Heart Association requests that this document be cited as follows: Elijovich F, Weinberger MH, Anderson CAM, Appel LJ, Bursztyn M, Cook NR, Dart RA, Newton-Cheh CH, Sacks FM, Laffer CL; on behalf of the American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional Genomics and Translational Biology; and Stroke Council. Salt sensitivity of blood pressure: a scientific statement from the American Heart Association. Hypertension. 2016;68:e7-e46. doi: 10.1161/HYP.0000000000000047.Expert peer review of AHA Scientific Statements is conducted by the AHA Office of Science Operations. For more on AHA statements and guidelines development, visit http://professional.heart.org/statements. Select the "Guidelines & Statements" drop-down menu, then click "Publication Development."Permissions: Multiple copies, modification, alteration, enhancement, and/or distribution of this document are not permitted without the express permission of the American Heart Association. Instructions for obtaining permission are located at http://www.heart.org/HEARTORG/General/CopyrightPermission-Guidelines_UCM_300404_Article.jsp. A link to the "Copyright Permissions Request Form" appears on the right side of the page. Figure 2 shows the major effect of aging in increasing the prevalence of SSBP in both normotensive and hypertensive subjects. An important and encouraging observation is that the multiple phenotypic characteristics described in pure SS strains of rodents reproduce those observed in humans, indicating that the phenotypic cluster of SSBP can be brought out in humans by the current techniques used in carefully controlled research. Additionally, despite the unquestionable influence of environmental factors in the determination of SSBP in humans, estimates of its heritability have been as high as 74% in blacks 9 and 50% in Chinese subjects, 10 both higher than those for hypertension. Salt Sensitivity of Blood PressureAn important issue is the clinical significance of the SSBP phenotype. There was increasing understanding that it represents an abnormality. The reasons w...

show abstract

“…30 Similarly, individuals with higher BMI have been shown to have higher RHR, 31 potentially due to increased sympathetic nervous system activation. 32,33 Higher BMI has also been associated with a significantly increased odds for having CAC. 34 Because it seems more physiologically plausible that smoking and increased body mass result in a higher RHR (instead of vice-versa), and both of these variables were significantly associated with CAC in our study population, we believe smoking and BMI are confounders rather than downstream mediators of the association between RHR and CAC.…”

Section: Allison Et Almentioning

confidence: 99%

Resting Heart Rate and Coronary Artery Calcium in Postmenopausal Women

Allison

Manson²,

Aragaki³

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

Objective: To test the hypothesis of a significant association between resting heart rate (RHR) and coronary artery calcium (CAC). Methods: This is a cross-sectional study of a subset of women enrolled in the estrogen-alone clinical trial of the Women's Health Initiative (WHI). We used a longitudinal study that enrolled 998 postmenopausal women with a history of hysterectomy between the ages of 50 and 59 at enrollment at 40 different clinical centers. RHR was measured at enrollment and throughout the study, and CAC was determined approximately 7 years after the baseline clinic visit. Results: The mean (standard deviation [SD]) age was 55 (2.8) years. With adjustment for age and ethnicity, a 10-unit increment in RHR was significantly associated with CAC (SD 1.18, 95% confidence interval [CI] 1.01-1.38), but this was no longer significant after adjustment for body mass index (BMI), income, education, dyslipidemia, diabetes, smoking, and hypertension (SD 1.06, 95% CI 0.90-1.25). In a fully adjusted multivariable model, however, there was a significant interaction ( p = 0.03) between baseline RHR and systolic blood pressure (SBP) for the presence of any CAC. Compared to women with an RHR < 80 beats per minute (BPM) and an SBP < 140 mm Hg, those who had an RHR ‡ 80 BPM and an SBP ‡ 140 mm Hg had 2.66-fold higher odds (1.08-6.57) for the presence of any CAC. Conclusions: Compared to those with normal BP and RHR, postmenopausal, hysterectomized women with an elevated SBP and RHR have a significantly higher odds for the presence of calcified coronary artery disease.

show abstract

Impact of body fat mass extent on cardiac autonomic alterations in women

Cited by 47 publications

References 41 publications

Detecting Sodium-Sensitivity in Hypertensive Patients

Detecting Sodium-Sensitivity in Hypertensive Patients

Salt Sensitivity of Blood Pressure

Resting Heart Rate and Coronary Artery Calcium in Postmenopausal Women

Contact Info

Product

Resources

About