2017
DOI: 10.1038/jp.2017.62
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Impact of brain injury on functional measures of amplitude-integrated EEG at term equivalent age in premature infants

Abstract: OBJECTIVE To evaluate the association between qualitative and quantitative amplitude-integrated EEG (aEEG) measures at term equivalent age (TEA) and brain injury on magnetic resonance imaging (MRI) in preterm infants. STUDY DESIGN A cohort of premature infants born at < 30 weeks of gestation and with moderate-to-severe MRI injury on a TEA MRI scan was identified. A contemporaneous group of gestational age-matched control infants also born at < 30 weeks of gestation with none/mild injury on MRI was also recru… Show more

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Cited by 9 publications
(6 citation statements)
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“…We chose aEEG as an examination metrod for early assessment. Studies have shown that aEEG scores of premature infants with brain injury were lower than those at the corresponding gestational age or adjusted gestational age [ 30 , 31 ]. Recent studies have pointed out a correlation of early aEEG parameters with short-term and long-term neurological outcomes [ 15 , 21 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…We chose aEEG as an examination metrod for early assessment. Studies have shown that aEEG scores of premature infants with brain injury were lower than those at the corresponding gestational age or adjusted gestational age [ 30 , 31 ]. Recent studies have pointed out a correlation of early aEEG parameters with short-term and long-term neurological outcomes [ 15 , 21 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…Some of these studies did not take into account the various clinical confounders in the NICU, as well as the socio-economic status after discharge, both of which may affect outcomes [9]. A recent study showed that brain injury on MRI at TEA in premature infants is closely correlated with delay in brain functional maturation on term aEEG measures [10]. In addition, no prior studies have evaluated the role of aEEG at TEA for prognostication.…”
Section: Introductionmentioning
confidence: 99%
“…Details are shown in Table 4. 17 We extended our aEEG analysis, showing that the observed differences in aEEG signals between infants with and without brain injury persisted until the age of 3 weeks, after correction for neonatal variables.…”
Section: Neurodevelopmental Outcomementioning
confidence: 82%