Impact of Cadaveric Renal Transplantation on Survival in Patients Listed for Transplantation

Oniscu, Gabriel C.; Brown, Helen; Forsythe, John

doi:10.1681/asn.2004121092

Cited by 305 publications

(210 citation statements)

References 14 publications

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…The survival benefit of kidney transplantation over dialysis treatment was previously demonstrated in various geographic areas with different health care systems. [1][2][3][4] Our study confirms these results and adds contemporary information from a large European cohort of dialysis patients who were on the waiting list. The relative mortality rate reduction of 55% in our cohort at 18 months after standard-criteria DBD kidney transplantation seems lower than previously reported (68 to 82% at 12 to 18 months after transplantation).…”

Section: Discussionsupporting

confidence: 80%

“…The relative mortality rate reduction of 55% in our cohort at 18 months after standard-criteria DBD kidney transplantation seems lower than previously reported (68 to 82% at 12 to 18 months after transplantation). [1][2][3][4] This difference may be the result of the more rigorous sequential stratification analysis used in this study, because analysis of our data using timedependent Cox regression produced a relative mortality rate reduction of 65% at 18 months after standard-criteria DBD kidney transplantation. Furthermore, the survival benefit of kidney transplantation in the United States extends to kidneys recovered from ECDs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kidneys from Donors after Cardiac Death Provide Survival Benefit

Snoeijs¹,

Schaubel

Hené

et al. 2010

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The continuing shortage of kidneys for transplantation requires major efforts to expand the donor pool. Donation after cardiac death (DCD) increases the number of available kidneys, but it is unknown whether patients who receive a DCD kidney live longer than patients who remain on dialysis and wait for a conventional kidney from a brain-dead donor (DBD). This observational cohort study included all 2575 patients who were registered on the Dutch waiting list for a first kidney transplant between January 1, 1999, and December 31, 2004. From listing until the earliest of death, living-donor kidney transplantation, or December 31, 2005, 459 patients received a DCD transplant and 680 patients received a DBD transplant. Graft failure during the first 3 months after transplantation was twice as likely for DCD kidneys than DBD kidneys (12 versus 6.3%; P ϭ 0.001). Standard-criteria DCD transplantation associated with a 56% reduced risk for mortality (hazard ratio 0.44; 95% confidence interval 0.24 to 0.80) compared with continuing on dialysis and awaiting a standard-criteria DBD kidney. This reduction in mortality translates into 2.4-month additional expected lifetime during the first 4 years after transplantation for recipients of DCD kidneys compared with patients who await a DBD kidney. In summary, standard-criteria DCD kidney transplantation associates with increased survival of patients who have ESRD and are on the transplant waiting list.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Kidneys from Donors after Cardiac Death Provide Survival Benefit

Snoeijs¹,

Schaubel

Hené

et al. 2010

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…Even among this age group, kidney transplantation provides a significant survival advantage compared with treatment with dialysis (2). For example, the life expectancy of patients who have ESRD and are older than 60 years is nearly doubled with transplantation (3). During the past decade, the number of deceased and living organ donors in the United States has increased (1).…”

Section: N Early Half Of a Million Individuals In The Unitedmentioning

confidence: 99%

Access to Kidney Transplantation among the Elderly in the United States

Schaeffner¹,

Rose²,

Gill³

2010

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

“…Transplantation is the most effective treatment for end stage renal disease providing a significant survival advantage over dialysis [2], however, the demand for kidney transplantation outstrips the supply of organs. Decreased numbers of donation after brain death (DBD) kidneys has led to increased interest in donation after cardiac death (DCD) kidney transplantation [3].…”

Section: Introductionmentioning

confidence: 99%