Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

Zídková, J.; Melčová, Magdalena; Bartosova, K.; Šestáková, Ivana; Zidek, Vaclav; Száková, Jiřina; Miholová, D.; Tlustoš, Pavel

doi:10.17221/7794-cjas

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Cd mainly accumulates in the liver and sometimes in the kidney (Cinar et al, 2011;Karmakar et al, 2000) due to the binding of Cd to metallothionein (Hardej and Trombetta, 2004). Absorption and in turn tissue accumulation of dietary Cd is mainly influenced by dose, age, gender, species, length of the application and nutritional status, as well as by dietary intake of other elements that may interact with Cd (Al-Waeli et al, 2013;Zídková et al, 2014). In agreement with our results, Leach et al (1979) revealed that liver in the treated chicken with dietary Cd was accumulated by higher concentration of Cd than muscles.…”

Section: Table 10supporting

confidence: 88%

“…In the present study, all levels of dietary Cd resulted in significant increases in the Cd concentration of muscles and liver in comparison with control. The distribution of Cd among organs of animals differs depending on the chemical form of administered Cd and the duration of exposure (Zídková et al, 2014). Cd mainly accumulates in the liver and sometimes in the kidney (Cinar et al, 2011;Karmakar et al, 2000) due to the binding of Cd to metallothionein (Hardej and Trombetta, 2004).…”

Section: Table 10mentioning

confidence: 99%

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The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels

Abou-Kassem

Mahrose

Alagawany

2016

Animal

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This study was conducted to verify whether vitamin (Vit) E or natural clay as feed additives has the potential to modulate the deleterious effects resulting from exposure to cadmium (Cd) in growing Japanese quail. 648 Japanese quail chicks (1 week old) were used to evaluate the effects of dietary Cd (0, 40, 80 and 120 mg/kg diet) and two levels of Vit E (0, 250 mg/kg diet) or two levels of natural clay (0 and 100 mg/kg diet) to study the influences of Cd, Vit E, clay or their different combinations on growth performance, carcass traits, some blood biochemical components and Cd residues in muscles and liver. Live BW and weight gain of quails were linearly decreased with increasing dietary Cd levels. Moreover, feed conversion was significantly worsened with increasing Cd level. Mortality percentage was linearly increased as dietary Cd level increased up to 120 mg/kg diet. Carcass percentage was linearly decreased as dietary Cd level increased. While, giblets percentage were linearly and quadratically differed as dietary Cd level increased. Cd caused significant changes in total plasma protein, albumin, globulin, A/G ratio, creatinine, urea-N and uric acid concentrations as well as ALT, AST and ALP activities. Increasing dietary Cd level was associated with its increase in the muscles and liver. Dietary supplementation with 250 mg of Vit E/kg diet or 100 mg clay/kg improved live BW, BW gain and feed conversion when compared with the un-supplemented diet. Quails fed diet contained 250 mg Vit E/kg and those fed 100 mg clay/kg had the highest percentages of carcass and dressing than those fed the un-supplemented diet. Blood plasma biochemical components studied were better when birds received 250 mg of Vit E/kg diet and those received 100 mg clay/kg. Cd residues in the muscles and liver were significantly less in the birds had 250 mg of Vit E/kg or those received 100 mg clay/kg diet than those un-supplemented with Vit E. Growth performance traits and blood plasma biochemical components studied were significantly affected linearly by the interactions among Cd and each of Vit E and clay levels. In conclusion, the present results indicate that the deleterious effects induced by Cd plays a role in decreasing the performance of Japanese quail and that dietary supplementation with natural clay or Vit E may be useful in partly alleviating the adverse effects of Cd.

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Section: Table 10supporting

confidence: 88%

Section: Table 10mentioning

confidence: 99%

The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels

Abou-Kassem

Mahrose

Alagawany

2016

Animal

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“…The intervention program (1980–2012) involved soil replacement in paddy fields, and since then, the Cd levels in rice grains have significantly declined [73, 74]. However, due to accumulation of Cd in the kidneys and its long biological half life promoted by binding to metallothioneins [75], new cases of itai-itai diseases are being diagnosed even today [73, 74]. Furthermore, as reported by most recent epidemiologic studies, low environmental Cd exposures are also linked with adverse health effects in humans.…”

Section: Cadmium As a Toxicantmentioning

confidence: 99%

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Zwolak

2019

Biol Trace Elem Res

242

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Arsenic (As) and cadmium (Cd) are elements arousing major public health concerns associated with environmental pollution, high toxicity potential, and carcinogenic nature. However, selenium (Se) at low doses and incorporated into enzymes and proteins has antioxidant properties and protects animals and humans from the risk of various diseases. It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement. The present article aims to update and expand the role of Se in As and Cd toxicity discussed in our earlier paper. In general, recent reports show that Se, regardless of its form (as selenite, selenomethionine, nanoSe, or Se from lentils), can reduce As- or Cd-mediated toxicity in the liver, kidney, spleen, brain, or heart in animal models and in cell culture studies. As was suggested in our earlier review, Se antagonizes the toxicity of As and Cd mainly through sequestration of these elements into biologically inert complexes and/or through the action of Se-dependent antioxidant enzymes. An increase in the As methylation efficiency is proposed as a possible mechanism by which Se can reduce As toxicity. However, new studies indicate that Se may also diminish As or Cd toxicity by activation of the Nrf2 pathway. In addition, this paper discusses possible signs of Se toxic effects, which may be a challenge for its future use in the therapy of As and Cd poisoning and provide future directions to address this issue.

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Detoxification of cadmium on the levels of urea and creatinine on Rattus norvegicus with tea mistletoe (Scurrula atropurpurea)

Hernayanti¹,

Lestari²,

Taufiq³

2019

AIP Conference Proceedings

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Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

Cited by 3 publications

References 45 publications

The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels

The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Detoxification of cadmium on the levels of urea and creatinine on Rattus norvegicus with tea mistletoe (Scurrula atropurpurea)

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