Impact of cardiovascular risk factors on cognitive function: The Tromsø study

Arntzen, Kjell Arne; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.

doi:10.1111/j.1468-1331.2010.03263.x

Cited by 93 publications

(106 citation statements)

References 28 publications

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“…Based on previous studies, HDL-C does not seem to associate with dementia or AD (Li et al 2005;Reitz et al 2010;Arntzen et al 2011) albeit the association is Total cholesterol, HDL cholesterol, systolic blood pressure, body mass index, apolipoprotein A-I, apolipoprotein B, and apolipoprotein B/A ratio were log-transformed before multivariate analysis a Model is not adjusted for total cholesterol apo A-I apolipoprotein A-I, HDL-C high density lipoprotein cholesterol, apo B apolipoprotein B, apo B/A ratio ratio between apo B and apo A-I seen in cross-sectional studies (Merched et al 2000). These findings are in line with our results where death is considered as a competing risk for dementia and AD, and statistically significant association is seen in CIF but not in Cox regression model between HDL-C and AD.…”

Section: Discussionmentioning

confidence: 96%

“…Higher total serum cholesterol (TC) in midlife is associated with higher risk of AD (Kivipelto et al 2001;Li et al 2005;Solomon et al 2007) but the association of TC and dementia risk is reversed in later life (Mielke et al 2005). Low levels of high density lipoprotein cholesterol (HDL-C) also associate with adverse cerebral white matter changes (Gouw et al 2008;Crisby et al 2010), but no clear association of HDL with the risk of dementia or AD has been found in prospective studies (Li et al 2005;Reitz et al 2005;Reitz et al 2010;Arntzen et al 2011). Apolipoprotein A-I (apo A-I) is the major surface protein of HDL-C, which is associated with lower risk for cardiovascular diseases (CVD).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

Tynkkynen

Hernesniemi

Laatikainen

et al. 2016

AGE

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Data on associations of apolipoproteins A-I and B (apo A-I, apo B) and HDL cholesterol (HDL-C) with dementia and Alzheimer's disease (AD) are conflicting. Our aim was to examine, whether apo B, apoA-I, their ratio, or HDL-C are significant, independent predictors of incident dementia and AD in the general population free of dementia at baseline. We analyzed the results from two Finnish prospective population-based cohort studies in a total of 13,275 subjects aged 25 to 74 years with mainly Caucasian ethnicity. The followup time for both cohorts was 10 years. We used Cox proportional hazards regression to evaluate hazard ratios (HR) for incident dementia (including AD) (n = 220) and for AD (n = 154). Cumulative incidence function (CIF) analysis was also performed to adjust the results for competing risks of death. Adjusted for multiple dementia and AD risk factors, log-transformed apo A-I, log HDL-C, log apo B, and log apo B/A-I ratio were not associated with incident dementia or AD. HDL-C was inversely associated with AD risk when adjusted for competing risks but no other statistically significant associations were observed in the CIF analyses. Apo A-I, HDL-C, apo B, or apo B/A-I ratio were not associated with future dementia or AD. HDL-C was inversely

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

Tynkkynen

Hernesniemi

Laatikainen

et al. 2016

AGE

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“…To date, investigations of smoking and incident MCI specifically, rather than dementia, have been lacking. However, studies examining the impact of current smoking on subsequent change in cognitive performance suggest that current smoking is associated with cognitive decline in individuals without dementia [55,56].…”

Section: Behavioural Factorsmentioning

confidence: 99%

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)

et al. 2016

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“…Out of nine cross-sectional studies, six studies reported on MI [27,[33][34][35][36][37], three on AP [34,36,37], and five on the CHD compound (MI+AP) [27,[37][38][39][40]. Of the six studies investigating MI, four found a significant relation with poor cognitive functioning [27,33,34,37], and two studies found no association with prevalent cognitive impairment [35,36].…”

Section: Case-control Studiesmentioning

confidence: 99%

“…In the meta-analysis, four studies representing 623,588 persons could be included [35,36,38,39]. CHD was not significantly associated with an increased risk of cognitive impairment or dementia (OR = 1.23, 95%CI = 0.76-1.97, p = 0.398; Figure H in S5 Appendix).…”

Section: Case-control Studiesmentioning

confidence: 99%

[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

Deckers

Schievink

Rodriquez

et al. 2017

Alzheimer's & Dementia

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Aims/HypothesisAccumulating evidence suggests an association between coronary heart disease and risk for cognitive impairment or dementia, but no study has systematically reviewed this association. Therefore, we summarized the available evidence on the association between coronary heart disease and risk for cognitive impairment or dementia. MethodsMedline, Embase, PsycINFO, and CINAHL were searched for all publications until 8 th January 2016. Articles were included if they fulfilled the inclusion criteria: (1) myocardial infarction, angina pectoris or coronary heart disease (combination of both) as predictor variable; (2) cognition, cognitive impairment or dementia as outcome; (3) population-based study; (4) prospective (!1 year follow-up), cross-sectional or case-control study design; (5) !100 participants; and (6) aged !45 years. Reference lists of publications and secondary literature were hand-searched for possible missing articles. Two reviewers independently screened all abstracts and extracted information from potential relevant full-text articles using a standardized data collection form. Study quality was assessed with the Newcastle-Ottawa Scale. We pooled estimates from the most fully adjusted model using random-effects metaanalysis. ResultsWe identified 6,132 abstracts, of which 24 studies were included. A meta-analysis of 10 prospective cohort studies showed that coronary heart disease was associated with increased risk of cognitive impairment or dementia (OR = 1.45, 95%CI = 1.21-1.74, p<0.001). Between-study heterogeneity was low (I 2 = 25.7%, 95%CI = 0-64, p = 0.207). Similar significant associations were found in separate meta-analyses of prospective cohort studies for the individual predictors (myocardial infarction, angina pectoris). In contrast, meta-analyses of cross-sectional and case-control studies were inconclusive. Funding: The author(s) received no specific funding for this work. Competing interests:The authors have declared that no competing interests exist. Conclusion/InterpretationThis meta-analysis suggests that coronary heart disease is prospectively associated with increased odds of developing cognitive impairment or dementia. Given the projected worldwide increase in the number of people affected by coronary heart disease and dementia, insight into causal mechanisms or common pathways underlying the heart-brain connection is needed.

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Impact of cardiovascular risk factors on cognitive function: The Tromsø study

Abstract: Diabetes, smoking, hypertension, and low physical activity were associated with lower cognitive test results. The study suggests that these modifiable risk factors should be emphasized in the prevention of cognitive decline.

Cited by 93 publications

References 28 publications

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer’s disease: the National Finnish population study (FINRISK)

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)

[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

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