Impact of Casein- versus Grain-Based Diets on Rat Renal Sodium Transporters’ Abundance and Regulation

McDonough, Alicia A.; Veiras, Luciana C.; McFarlin, Brandon E.; Ralph, Donna L.

doi:10.34067/kid.0006702020

Kidney360

2021

DOI: 10.34067/kid.0006702020

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Impact of Casein- versus Grain-Based Diets on Rat Renal Sodium Transporters’ Abundance and Regulation

Alicia A. McDonough

Luciana C. Veiras

Brandon E. McFarlin

et al.

Abstract: This is an Early Access article. Please select the PDF button, above, to view it.

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Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺

Edwards,

Ralph,

Mercado

et al. 2023

American Journal of Physiology-Renal Physiology

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Chronic infusion of subpressor level of Angiotensin II (AngII) increases the abundance of Na+ transporters along the distal nephron, balanced by suppression of Na+ transporters along the proximal tubule and medullary thick ascending limb (defined as proximal nephron), which impacts K+ handling along the entire renal tubule. The objective of this study was to quantitatively assess the impact of chronic AngII on the renal handling of Na+ and K+ in female rats, using a computational model of the female rat renal tubule. Our results indicate that downregulation of proximal nephron Na+ reabsorption (TNa), which occurs in response to AngII-triggered hypertension, involves changes in both transporter abundance and trafficking. Our model suggests that substantial (~ 30%) downregulation of active NHE3 in proximal tubule (PT) microvilli is needed to reestablish the Na+ balance at 2 weeks of AngII infusion. The 35% decrease in SGLT2, a known NHE3 regulator, may contribute to this downregulation. Both depression of proximal nephron TNa and stimulation of distal ENaC raise urinary K+ excretion in AngII-treated females, while K+ loss is slightly mitigated by cortical NKCC2 and NCC upregulation. Our model predicts that K+ excretion may be more significantly limited during AngII infusion by ROMK inhibition in the distal nephron, and/or KCC3 upregulation in the PT, which remain open questions for experimental validation. In summary, our analysis indicates that AngII hypertension triggers a series of events from distal TNa stimulation followed by compensatory reduction in proximal nephron TNa and accompanying adjustments to limit excessive K+ secretion.

show abstract

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺

Edwards,

Ralph,

Mercado

et al. 2023

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

show abstract

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Impact of Casein- versus Grain-Based Diets on Rat Renal Sodium Transporters’ Abundance and Regulation

Abstract: This is an Early Access article. Please select the PDF button, above, to view it.

Cited by 1 publication

References 18 publications

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺

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Impact of Casein- versus Grain-Based Diets on Rat Renal Sodium Transporters’ Abundance and Regulation

Abstract: This is an Early Access article. Please select the PDF button, above, to view it.

Cited by 1 publication

References 18 publications

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+

Contact Info

Product

Resources

About

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na⁺ and K⁺