Impact of Charlson’s comorbidity index on overall survival following tumor nephrectomy for renal cell carcinoma

Abstract

There was significant improvement in the quality of life, following tumor nephrectomy, even for Stage-IV cancers. Multivariate analysis indicated besides tumor stage, grade, and size of the tumor, Charlson's index has a significant predictive value on overall survival.

Hospital admissions in elderly patients on chronic hemodialysis

“…Comorbidity, quantified by the Charlson indexwhich includes diabetes-was the most important predictor of hospitalizations in this study. The Charlson index predicts various outcomes in populations with kidney disease [33][34][35] and along with age was found to predict mortality in HD patients [36]. The Charlson score of octogenarians did not differ from that of younger HD patients in this study.…”

Chronic pulmonary diseases are independent risk factors for complications after radical nephrectomy

“…CCI index is based on 19 categories of comorbidity [3]. Ather and Nazim [14] evaluated the impact of CCI on overall survival following tumor nephrectomy, and identified that CCI had a significant predictive value on overall survival. However, when we searched Medline, we could not reach published data investigating the association between CCI and CPCS in RN cases.…”

Significance of pretreatment comorbidities in elderly patients with advanced non-small-cell lung cancer treated with chemotherapy or epidermal growth factor receptor-tyrosine kinase inhibitor

“…This index was initially validated in a cohort of breast cancer patients [12], giving a method of measuring the prognostic impact of comorbid disease. Since this initial publication, the CCI has been validated and used in several cancer studies, including head and neck [17,18], stomach [19], bladder [20], kidney [21], prostate [22], renal cell carcinoma [23], lung cancer [11,13,24], and cancer in the elderly [25]. In some cancer studies, including head and neck [17], bladder [20], prostate [22], early stage NSCLC [11], the effect of CCI on survival has been proven.…”