Impact of chemotherapy-associated liver injury on tumour regression grade and survival in patients with colorectal liver metastases

Zhao, Jizhong; Sawo, Pamir; Rensen, Sander S.; Rouflart, M.; Winstanley, Alison; Vreuls, Celien P.H.; Verheij, Joanne; Mierlo, Kim M.C. van; Lodewick, Toine M.; Woerden, Victor van; Tiel, Frank H. van; Dam, Ronald M. van; Dejong, Cornelis H. C.; Damink, Steven W. M. Olde

doi:10.1016/j.hpb.2017.08.030

Cited by 13 publications

(20 citation statements)

References 33 publications

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“…Both colorectal carcinoma and HCC had Grade 3 toxicity rates above the group mean for several lab values. This finding reflects baseline hepatotoxicity from previous chemotherapy used for colorectal carcinoma and underlying cirrhosis in HCC (18)(19)(20). The 1.1% incidence of likely radiation-induced liver disease (7/614 patients) is slightly lower than the 4% rate described by Kennedy et al (13).…”

Section: Discussionmentioning

confidence: 66%

Incidence and risk factors for sustained hepatic function toxicity 6 months after radioembolization: analysis of the radiation-emitting sir-spheres in non-resectable liver tumor (RESIN) registry

Brown¹,

Krebs²,

Brower³

et al. 2021

J Gastrointest Oncol

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Background: To quantify rates and risk factors for toxicity after hepatic radioembolization using resin yttrium-90 microspheres.Methods: Radiation-Emitting SIR-Spheres in Non-resectable liver tumor (RESIN) registry enrollees were reviewed with 614 patients included. Mean patient age was 63.1±12.5 years. The majority of patients were male (n=375, 61%) and white (n=490, 80%). Common tumor types were hepatocellular (n=197, 32%), colorectal (n=187, 30%) and neuroendocrine (n=56, 9%). Hepatotoxicity was measured using the Common Terminology Criteria for Adverse Events (CTCAE v 5). Potential risk factors for hepatotoxicity were tested using the Kruskal-Wallis or Pearson Chi-squared tests, and multivariate linear regressions.Results: At 6 months, 115 patients (18.7%) died (n=91, 14.8%), entered hospice (n=20, 3.3%) or sought treatment elsewhere (n=4, 4%). Seven (1.1%) deaths were from liver decompensation. Grade 3 toxicity rates were: bilirubin (n=85, 13.8%), albumin (n=28, 4.6%), ALT (n=26, 4.2%) and AST (n=37, 6.0%). For each of these liver function test components, baseline abnormal labs predicted Grade 3 toxicity at followup by Kruskal-Wallis test (P<0.001) and linear regression (all P<0.03). Other significant factors predicting toxicity at regression included elevated Body-Mass Index (albumin P=0.0056), whole liver treatment (bilirubin P=0.046), and lower tumor volume (ALT and INR, P<0.035 for both).Conclusions: Baseline liver function abnormalities prior to radioembolization is the strongest predictor of post-treatment Grade 3 toxicity with rates as high as 13.8%. Toxicity rates for specific lab values are affected by large volume treatments especially with low tumor volumes.

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Section: Discussionmentioning

confidence: 66%

Incidence and risk factors for sustained hepatic function toxicity 6 months after radioembolization: analysis of the radiation-emitting sir-spheres in non-resectable liver tumor (RESIN) registry

Brown¹,

Krebs²,

Brower³

et al. 2021

J Gastrointest Oncol

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“…Even if not associated with prognosis, some studies highlighted an inverse relationship between CALI and response to chemotherapy (tumor regression is less evident in patients with severe injuries). 3,13 NEW OUTLOOKS: FUNCTIONAL IMAGING AND TEXTURE ANALYSIS Hepatobiliary scintigraphy (HBS) with 99m Tc-labeled iminodiacetate derivatives could open new perspectives. In staged procedures, HBS demonstrated accurate evaluation of liver function, outperforming volumetric assessments and liver function tests.…”

Section: Cali Diagnosis: a Riddle To Solvementioning

confidence: 99%

Chemotherapy-Associated Liver Injuries: Unmet Needs and New Insights for Surgical Oncologists

et al. 2021

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“…It aims on removing all the tumour tissues from the patient's body, while sparing healthy tissues to preserve function. The intraoperative decisions made by the surgeon to perform the resection are critical for patient survival (9)(10)(11). Unsuccessful surgeries with potential remaining tumour tissues inside the patient can lead to reoperations or heavy complementary treatments such as radiotherapy or chemotherapy affecting the quality of life and the survival of the patient.…”

Section: Intraoperative Decisions and Reference Diagnosticsmentioning

confidence: 99%

“…Tissues are then fixed in formalin for hours for optimal histology and long term storage at room temperature. The distance between the tumour and the resection cut is referred as resection margin width and has been reported as an independent prognostic factor on patient's outcome for several malignancies (9)(10)(11)22). The distance between the inked margin and the first encountered tumours cells are then inspected microscopically to define the success of the surgery ( fig.…”

Section: Intraoperative Decisions and Reference Diagnosticsmentioning

confidence: 99%

“…Het heeft tot doel al het tumorweefsel te verwijderen om de patiënt van kanker te genezen, terwijl gezonde weefsels worden gespaard om biologische functies te behouden. Intraoperatieve beslissingen bij de uitvoering van een ressectie zijn van cruciaal belang voor het resultaat voor de patiënt (9)(10)(11). Dit is deels te wijten aan het feit dat de macroscopische identificatie ter plaatse van tumor of gezond weefsel vaak lastig is voor chirurgen.…”

Section: Samenvatting In Het Nederlandsunclassified

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Real-Time Molecular Patterns to support Intraoperative Decision-Making

Vaysse

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Impact of chemotherapy-associated liver injury on tumour regression grade and survival in patients with colorectal liver metastases

Abstract: CALI was not directly related to survival. CALI was, however, associated with diminished complete tumour response, and diminished complete tumour response, in turn, was associated with decreased survival.

Cited by 13 publications

References 33 publications

Incidence and risk factors for sustained hepatic function toxicity 6 months after radioembolization: analysis of the radiation-emitting sir-spheres in non-resectable liver tumor (RESIN) registry

Incidence and risk factors for sustained hepatic function toxicity 6 months after radioembolization: analysis of the radiation-emitting sir-spheres in non-resectable liver tumor (RESIN) registry

Chemotherapy-Associated Liver Injuries: Unmet Needs and New Insights for Surgical Oncologists

Real-Time Molecular Patterns to support Intraoperative Decision-Making

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