Impact of Chemotherapy-Induced Nausea and Vomiting on Quality of Life in Indonesian Patients With Gynecologic Cancer

Perwitasari, Dyah Aryani; Atthobari, Jarir; Mustofa, Mustofa; Dwiprahasto, Iwan; Hakimi, Mohammad; Gelderblom, Hans; Putter, Hein; Nortier, J.W.R.; Guchelaar, Henk‐Jan; Kaptein, Ad A.

doi:10.1097/igc.0b013e318234f9ee

Cited by 24 publications

(18 citation statements)

References 19 publications

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“…It has already been demonstrated that adjuvant chemotherapy and radiotherapy administered after surgery to patients with advanced or high-risk disease can lead to short-or long-term consequences on QOL. 4,5 According to previous studies, women often experience serious disruptions in sexual function after treatment for EC. 6 Surgery and adjuvant radiotherapy can damage sex organs, neuronal structures, and ovarian function, which may seriously impair sexual function.…”

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confidence: 99%

Sexual Function and Quality of Life Among Patients With Endometrial Cancer After Surgery

Gao

Xiao

Bai

et al. 2017

International Journal of Gynecological Cancer

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confidence: 99%

Sexual Function and Quality of Life Among Patients With Endometrial Cancer After Surgery

Gao

Xiao

Bai

et al. 2017

International Journal of Gynecological Cancer

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“…Severe and poorly controlled CINV was ranked near death by patients undergoing chemotherapy (6). Chemotherapy-induced nausea and vomiting not only has the propensity to increase morbidity, and healthcare cost, but also interferes with the chemotherapy adherence and patient's QoL (9)(10)(11)(12)(13)(14)(15)(16)(17). The current antiemetic agents exert their action by targeting various receptors , neurokinin 1 (NK1), dopamine, etc.]…”

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confidence: 99%

Expert Consensus on Effective Management of Chemotherapy-Induced Nausea and Vomiting: An Indian Perspective

et al. 2020

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Chemotherapy-induced nausea and vomiting (CINV) is one of the most common and feared side effects in cancer patients undergoing chemotherapy. Scientific evidence proves its detrimental impact on a patient's quality of life (QoL), treatment compliance, and overall healthcare cost. Despite the CINV-management landscape witnessing a radical shift with the introduction of novel, receptor-targeting antiemetic agents, this side effect remains a chink in the armor of a treating oncologist. Though global guidelines acknowledge patient-specific risk factors and chemotherapeutic agent emetogenic potential in CINV control, a "one-fit-for-all" approach cannot be followed across all geographies. Hence, in a pioneering attempt, India-based oncologists conveyed easily implementable, region-specific, consensus-based statements on CINV prevention and management. These statements resulted from integrating the analysis of scientific evidence and guidelines on CINV by the experts, with their clinical experience. The statements will strengthen decision-making abilities of Indian oncologists/clinicians and help in achieving consistency in CINV prevention and management in the country. Furthermore, this document shall lay the foundation for developing robust Indian guidelines for CINV prevention and control.

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“… 1 It has a detrimental effect on the quality of life of patients and their functional well-being. 2 - 4 Uncontrolled nausea or vomiting is also associated with frequent hospital and emergency department visits, is resource consuming, 5 - 8 and can lead to impaired compliance with chemotherapy. 1 , 9 , 10…”

Section: Introductionmentioning

confidence: 99%

Survey of Implementation of Antiemetic Prescription Standards in Indian Oncology Practices and Its Adherence to the American Society of Clinical Oncology Antiemetic Clinical Guideline

Patil

Noronha²,

Joshi

et al. 2017

JGO

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PurposeAdherence to international antiemetic prophylaxis guidelines like those of ASCO can result in better control of chemotherapy-induced nausea and vomiting; however, the extent of implementation of such guidelines in India is unknown. Therefore, this survey was planned.MethodsThis study was an anonymized cross-sectional survey approved by the ethics committee. Survey items were generated from the clinical questions given in the ASCO guidelines. The survey was disseminated through personal contacts at an oncology conference and via e-mail to various community oncology centers across India. The B1, B2, and B3 domains included questions regarding the optimal antiemetic prophylaxis for high, moderate, and low-minimal emetogenic regimens.ResultsSixty-six (62.9%) of 105 responded and 65 centers (98.5%) were aware of the published guidelines. The partial, full, and no implementation scores were 92.5%, 4.5%, and 3.0%, respectively. Full implementation was better for the low-minimal emetogenic regimens (34.8%) than the highly emetogenic regimens (6.1%). The three most frequent reasons for hampered implementation of ASCO guidelines in routine chemotherapy practice cited by centers were a lack of sensitization (26 centers; 39.4%), lack of national guidelines (12 centers; 18.2%), and lack of administrative support (10 centers; 15.2%).ConclusionAwareness regarding ASCO antiemetic guidelines is satisfactory in Indian oncology practices; however, there is a need for sensitization of oncologists toward complete implementation of these guidelines in their clinical practice.

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Impact of Chemotherapy-Induced Nausea and Vomiting on Quality of Life in Indonesian Patients With Gynecologic Cancer

Cited by 24 publications

References 19 publications

Sexual Function and Quality of Life Among Patients With Endometrial Cancer After Surgery

Sexual Function and Quality of Life Among Patients With Endometrial Cancer After Surgery

Expert Consensus on Effective Management of Chemotherapy-Induced Nausea and Vomiting: An Indian Perspective

Survey of Implementation of Antiemetic Prescription Standards in Indian Oncology Practices and Its Adherence to the American Society of Clinical Oncology Antiemetic Clinical Guideline

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