Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

Elbassuoni, Eman; Hafez, Sara M Abdel

doi:10.1007/s12192-019-00988-y

Cited by 16 publications

(12 citation statements)

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“…Structural changes of the pancreas, in particular, the vascular bed, as a reaction to the pathological process in the body, regardless of its origin, attracts attention, mainly due to the involvement of the gland in endocrine and exocrine function [3,4]. At disturbance of blood circulation, the morphological changes which are followed by hypotoxic changes which become rather defining in functional ability of organ grow.…”

Section: Discussionmentioning

confidence: 99%

“…Burn disease develops when 15-20 % of the body surface is damaged, and its severity is determined by the area and depth of damage to the skin. Burn disease has a complex multicomponent pathogenesis, characterized by hypovolemia, circulatory disorders, especially microcirculation, severe intoxication and infection of the body, including the pancreas [3,4,11,17,18,20,23,25,26,35].…”

Section: Introductionmentioning

confidence: 99%

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Microscopic changes of the pancreas vessels in the dynamics after experimental thermal injury

Zykova

2021

Biomed. and Biosoc. Anthrop.

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The problem of burns is relevant in the world and in Ukraine. Thermal injury is not limited to local tissue changes, but causes significant morphofunctional disorders in the organs and systems of the affected organism, the result of this factor is a violation of blood supply to organs, including the pancreas. The aim of this work was to establish the histological condition of the vessels of the pancreas after experimental thermal injury. The experiments were performed on 40 adult white rats. Burns were applied under thiopental-sodium anesthesia with copper plates at a temperature of 96-97℃ on the epilated surface of the skin of the back of animals for 15 seconds (the lesion area was 18-20 % of the body surface). Decapitation of animals was performed on 1, 7, 14 and 21 days of the experiment. Pieces of the pancreas were taken for histological examination and processed according to generally accepted methods. Histological sections 5-6 μm thick were stained with hematoxylin-eosin, impregnated with silver by the Gordon-Sweets method, as well as staining by the tricolor method of MSB (ORB). Histological specimens were examined and documented using an SEO SCAN light microscope and a Vision CCD Camera. In the early stages of the experiment revealed a violation of the blood supply to the body. The lumens of most arteries were found to be dilated, and the wall thickness increased due to hypertrophy of the smooth muscle cells of the media. Leukocyte infiltration was determined in the perivascular spaces. The lumens of the small and middle veins were dilated and filled with blood, with parietal thrombi in some of them. Capillaries are characterized by a moderate expansion of their lumens, stasis. There was swelling of the paravasal spaces. Significant destructive-degenerative, inflammatory and sclerotic changes were observed in the later stages of the experiment. The walls of the vessels were moderately swollen. Smooth myocytes of the arterial media were hypertrophied, the cytoplasm was vacuolated, and contained pyknotically altered nuclei. Adventitia of vessels, especially veins, was swollen and fibrous. Occasionally there were violations of the wall of the components of the microcirculatory tract, which was accompanied by hemorrhage. There are single thrombosed vessels, spasmed arterioles, hemocapillaries with dilated lumens. The greatest changes, especially on the 21st day, were the adventitial membrane with the growth of collagen and reticular fibers. The blood supply to the vessels was moderate. Vessels of small diameter and hemomicrocirculatory tract were also significantly altered, their wall is deformed, thin, homogeneous. The lumens are dilated, with the formation of blood clots. Thus, in the early stages of the experiment there are adaptive-compensatory processes and initial destructive changes in the walls of the vessels of the organ, manifested by stasis, thrombosis, edema, deformation, infiltration of the wall and perivascular space. In the late period, significant destructive-degenerative changes in the structure of the walls of the vessels of the pancreas, accompanied by hemorrhage, inflammation, sclerosis of the wall and edema of the adventitia. These changes lead to a deterioration of blood supply and, consequently, a decrease in the functional activity of the body.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microscopic changes of the pancreas vessels in the dynamics after experimental thermal injury

Zykova

2021

Biomed. and Biosoc. Anthrop.

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“…This storm leads to dysfunctional, uncontrolled, continuous activation of inflammation. Finally, inflammation is proposed strongly to link stress to stress-related diseases, and multiple types of research documented that excessive inflammation is directly involved in the pathophysiology of stress-related disease ( Elbassuoni and Abdel Hafez, 2019 ; Hafez et al, 2020 ). There is evidence that inflammation leads to subsequent acute respiratory distress syndrome, renal failure, myocardial injury, the severity of illness, the requirement of intensive care unit admission, lately, the requirement of mechanical ventilation, and mortality.…”

Section: Pathophysiology Of Coronavirusmentioning

confidence: 99%

Can Covid-19 attack our nervous system?

Hafez

2021

Journal of Chemical Neuroanatomy

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Nowadays, Covid-19 is considered a serious health problem worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (COVID-19). It is well known that the Corona Virus attacks mainly the respiratory system. Meanwhile, it has been established that coronavirus infection can extend beyond the respiratory system and unfortunately, can also affect our nervous system. Multiple neurological symptoms and signs had been documented during and post covid conditions. This virus gets access to the central nervous system (CNS) via the bloodstream leading to infect the endothelial lining cells. Also, it was reported that the virus can enter the peripheral nervous system via retrograde neuronal routes. The virus could be internalized in nerve synapses through endocytosis, transported retrogradely, and spread trans-synoptically to other brain regions. This minireview highlights the possible routes by which SARS-CoV-2 can invade the central nervous system (CNS) and its pathophysiology and manifestation.

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“…This was performed using power × 400 from 10 successive nonoverlapping fields. [69] 4.2.6 | Statistical analysis…”

Section: Morphometric Studymentioning

confidence: 99%

Design and synthesis of hydrazinecarbothioamide sulfones as potential antihyperglycemic agents

Aly

Hassan

Makhlouf

et al. 2021

Archiv der Pharmazie

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New hydrazinecarbothioamides with a phenylsulfonyl group were synthesized and their structures were identified by different spectroscopic data ( 1 H NMR, 13 C NMR, two-dimensional NMR, mass spectrometry, elemental analysis, and single-crystal X-ray analysis). The mechanism describing the formation of the products was also discussed.The antidiabetic activity of the isolated products was investigated histochemically. The synthesized sulfonylalkylthiosemicarbazide exhibited antihyperglycemic activity in streptozotocin-induced diabetic mice. Compounds 5a and 5c significantly lowered the blood glucose level to 103.3 ± 1.8 and 102 ± 3.9 mg/dl, respectively. Also, they caused a significant decrease in malondialdehyde levels and normalized the glutathione levels in streptozotocin-induced diabetic mice, compared with the diabetic group. The results suggest that the synthesized hydrazinocarbothioamides may effectively inhibit the development of oxidative stress in diabetes. K E Y W O R D S4-substituted hydrazinecarbothioamides, antihyperglycemic activity, bis(2-(phenylsulfonyl)ethyl)sulfane, glutathione, malondialdehyde, sulfonylalkylthiosemicarbazide | INTRODUCTIONDue to the significant impact of sulfone compounds in biological applications, the development of new sulfone-containing compounds remains one of the central challenges of organic chemistry. [1,2] There are many sulfones widely reported in the literature with a broad spectrum of biological activities such as anticancer, [3] antimicrobial, [4] antiinflammatory, [5] antiproliferative, [6,7] antimalarial [8] and anti-HIV activities. [9] Catalytic chemoselective addition of amino alcohols to α,βunsaturated sulfonyl derivatives leads to the regioselective formation of amino and hydroxy adducts, depending on different catalysts and reaction conditions. [10,11] N-Substituted hydrazinecarbothioamides are considered as one of the most important classes of compounds containing nitrogen, sulfur, and oxygen used for heterocyclization and formation of different heterocyclic rings such as thiadiazole and thiadiazepine, and from the reaction with several π-deficient compounds. [12][13][14][15] The literature approach was applied to 4-(1-phenyl-1Htetrazole-5-ylsulfonyl)butanenitrile (PTSB), a growth inhibitory compound with a previously unknown mode of action, and the thioredoxin/ thioredoxin reductase system was identified as its target. [16] Another patent showed compounds having CH 2 CH 2 SO 2 Ar functional group as histone deacetylase inhibitors. [17][18] The synthesis of various heterocyclic

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Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

Cited by 16 publications

References 75 publications

Microscopic changes of the pancreas vessels in the dynamics after experimental thermal injury

Microscopic changes of the pancreas vessels in the dynamics after experimental thermal injury

Can Covid-19 attack our nervous system?

Design and synthesis of hydrazinecarbothioamide sulfones as potential antihyperglycemic agents

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