Impact of Chronic Hepatitis B Virus Infection On Semen Parameters of Fertile Men

Taha, Emad A.; Mekky, Mohamed A.; Gaber, Hisham Diab; Abdel-Gaber, Reham Maher; Zahran, Asmaa M; Allah, Eman S. Abd; Mohamed, Ahmed Q; Hasaballah, Ashraf E; Mostafa, Taymour; Hetta, Helal F

doi:10.2217/fvl-2019-0039

Cited by 3 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), herpes simplex virus, and cytomegalovirus (CMV), can cause male infertility (6). Several studies in Iran have indicated that CMV and HBV infections play a major role in male infertility (2,7). It has been reported that CMV can be extracted from almost all body secretions, including vaginal and cervical secretions, seminal fluid, oropharyngeal secretions, and milk, as well as stool, urine, and blood (8).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis B Virus and Cytomegalovirus Infections Disrupt Sperm Parameters in Males through Decreasing Mitochondrial Membrane Potential: A Case-control Study

Neisi

Noorbakhsh

Hashemitabar

et al. 2022

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Infertility is a global problem that affects more than 15% of couples. The occurrence of this problem is about 50% in males. Viral infections cause infertility in men by different mechanisms. Objectives: This study is designed to evaluate the effects of hepatitis B virus (HBV) and cytomegalovirus (CMV) infection on male fertility and determine the mechanisms involved. Methods: A total of 73 males were included in the present study. They were assigned to the groups healthy fertile (n = 22 volunteers) as the healthy controls, non-infected infertile (n = 27), HBV-infected infertile (n = 14), and CMV-infected infertile (n = 10). The sperm parameters, including count, morphology, progressive motility (PR), and progressive + non-progressive motility (PR + NP), were analyzed in their semen. The semen samples of all studied participants were subjected to polymerase chain reaction to determine the presence of HBV or CMV infection. Mitochondrial membrane potential (MMP) and tumor necrosis factor-alpha (TNF-α) were also assessed. Results: Our findings showed that all sperm parameters, including count, morphology, PR, and PR + NP, decreased in males with HBV and CMV infections compared to the healthy control group (P < 0.01 in all cases). MMP declined in HBV- and CMV-infected males compared to the healthy control group (P < 0.001). Conversely, the TNF-α level of semen in HBV- and CMV-infected men was significantly higher than in the healthy control group (P < 0.001). Conclusions: The results of the present study demonstrated that HBV and CMV infections lead to male infertility through increasing TNF-α and decreasing sperm MMP.

show abstract

Section: Introductionmentioning

confidence: 99%

“…HBV transmits via genital secretions and sexual contact. This virus was established to disrupt sperm parameters and release inflammatory cytokines (7). Inflammatory cytokines are induced in the early phase of viral infections.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus and Cytomegalovirus Infections Disrupt Sperm Parameters in Males through Decreasing Mitochondrial Membrane Potential: A Case-control Study

Neisi

Noorbakhsh

Hashemitabar

et al. 2022

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

Sperm Vitality

Salvio,

Zenoaga-Barbăroșie

2024

Human Semen Analysis

View full text Add to dashboard Cite

Evaluation of the Immune Memory Response to Routine Hbv Vaccine in Egyptian Patients With Type 1 Diabetes

et al. 2020

View full text Add to dashboard Cite

We aimed to evaluate the immune memory response to HBV vaccine in diabetic patients who had received the full HBV vaccination during infancy and to assess the need for booster doses. Blood samples were collected from children (93 diabetics and 105 controls) and university students (22 diabetics and 20 controls). Anti-HBs titer in serum and after in vitro stimulation of peripheral blood mononuclear cells with HBV vaccine was measured by ELISA. Diabetic groups had significantly lower anti-HBs levels after 10 years of the last HBV vaccine dose. The percentage of diabetic patients having protective anti-HBs titers was significantly lower than controls. In conclusion, diabetic patients had lower immune response to HBV vaccine over time, emphasizing the need for a booster dose.

show abstract

Impact of Chronic Hepatitis B Virus Infection On Semen Parameters of Fertile Men

Cited by 3 publications

References 20 publications

Hepatitis B Virus and Cytomegalovirus Infections Disrupt Sperm Parameters in Males through Decreasing Mitochondrial Membrane Potential: A Case-control Study

Hepatitis B Virus and Cytomegalovirus Infections Disrupt Sperm Parameters in Males through Decreasing Mitochondrial Membrane Potential: A Case-control Study

Sperm Vitality

Evaluation of the Immune Memory Response to Routine Hbv Vaccine in Egyptian Patients With Type 1 Diabetes

Contact Info

Product

Resources

About