2021
DOI: 10.3390/antibiotics10080886
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Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model

Abstract: Studying potential dietary exposure to antimicrobial drug residues via meat and dairy products is essential to ensure human health and consumer safety. When studying how antimicrobial residues in food impact the development of antimicrobial drug resistance and disrupt normal bacteria community structure in the intestine, there are diverse methodological challenges to overcome. In this study, traditional cultures and molecular analysis techniques were used to determine the effects of tetracycline at chronic sub… Show more

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Cited by 10 publications
(13 citation statements)
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“…An adverse effect of antibiotics on the host refers to damage to the microbiota, generating alterations in the metabolism of sugars and lipids. In this study, this factor was not controlled [ 49 ]. The gut microbiome plays an important role in extracting energy from food and inducing obesity [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…An adverse effect of antibiotics on the host refers to damage to the microbiota, generating alterations in the metabolism of sugars and lipids. In this study, this factor was not controlled [ 49 ]. The gut microbiome plays an important role in extracting energy from food and inducing obesity [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thanks to improved bioreactor control technology, these microorganisms can now be cultured in vitro at significantly higher enrichment levels. Moreover, bioreactors have been used to explore the gut microbiota ecology and its response to treatments incompatible with in vivo models, such as chronic exposure to antibiotics, infection with multi-drug-resistant bacteria, and exposure to xenobiotics . Other applications include research on food fermentation, substrate bioaccessibility, prebiotics and probiotics, , and the impact of phenolic compounds. , Polyphenols have become an active research area after being linked with beneficial effects on gut microbiota and disorders such as obesity, diabetes, cardiometabolic diseases, and neurodegenerative diseases …”
Section: Introductionmentioning
confidence: 99%
“…The human intestinal microbiota includes all kinds of microorganisms, including fungi, protozoa, bacteria, and viruses (Piñeiro and Cerniglia, 2021). The intestinal microbiota has several physiological roles, including in host immunity and metabolic processes and in the integrity of the intestines and gut epithelium (Ahn et al, 2021;Sadighara et al, 2022). Colonic bacteria are gram-negative anaerobic bacteria that perform several metabolic activities, including carbohydrate fermentation, production of vitamins B and K, and polysaccharide hydrolysis (Riley et al, 2013;Jung et al, 2018).…”
Section: Introductionmentioning
confidence: 99%