Impact of ciprofloxacin, carbamazepine and ibuprofen on a membrane bioreactor system: Kinetic study and biodegradation capacity

Calero-Díaz, G.; Monteoliva-García, Antonio; Leyva‐Díaz, Juan Carlos; López-López, C.; Martín-Pascual, J.; Torres, Juan Carlos; Poyatos, J. M.

doi:10.1002/jctb.5316

Cited by 20 publications

(17 citation statements)

References 46 publications

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“…Li and Zhang reported that no biodegradation of ciprofloxacin occurred during wastewater treatment with a conventional activated sludge process. Calero‐Díaz et al demonstrated that using a membrane bioreactor in aerobic conditions presented a high removal rate of ≤89% of ciprofloxacin, at HRT = 6 h. Ciprofloxacin was removed totally using a laboratory‐scale MBR compared with an anaerobic‐anoxic‐aerobic process . This indicated that MBR technology reduced the pharmaceuticals without reducing the removal capacity of the organic matter.…”

Section: Resultsmentioning

confidence: 99%

“…The obtained metformin and ciprofloxacin removal were in the range of 70–77%. Removals of metformin and ciprofloxacin between 20% and 99% have been reported applying membrane bioreactor technology (MBR) under anaerobic, anoxic and aerobic conditions . A metformin removal of between 90% and 99.7% has been obtained through oxidation ditches .…”

Section: Introductionmentioning

confidence: 99%

“…Removals of metformin and ciprofloxacin between 20% and 99% have been reported applying membrane bioreactor technology (MBR) under anaerobic, anoxic and aerobic conditions. [24][25][26][27][28][29][30] A metformin removal of between 90% and 99.7% has been obtained through oxidation ditches. 31 Estrada-Arriaga et al 5 found that full-scale oxidation ditches can remove up to 91% and 97% of metformin and between 21% and 89% of ciprofloxacin.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

García‐Sánchez

Gutiérrez‐Macías

Estrada‐Arriaga

2019

J of Chemical Tech & Biotech

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BACKGROUND Several studies have demonstrated that the pharmaceuticals detected in the influents and effluents of wastewater treatment plants (WWTPs) can cause endocrine disruption and bacterial resistance on different species, in an aquatic environment. Metformin (antidiabetic drug) and ciprofloxacin (antibiotic quinolones) are compounds found at higher concentrations than many other pharmaceuticals, and thus have a disproportionately large environmental impact. This study is focused on the assessment of an aerated biofilter packed with Ficus benjamina wood chips for the simultaneous removal of metformin, ciprofloxacin, organic matter expressed as chemical oxygen demand (COD) and ammoniacal nitrogen (NH3‐N) during domestic wastewater treatment, under different superficial hydraulic loading. RESULTS The maximum removals of metformin, ciprofloxacin, COD and NH3‐N from the wastewater treated in an aerated biofilter were 94, 81, 91 and 38%, respectively, by applying a superficial hydraulic loading of 0.18 m3 m–2 d–1 [hydraulic retention time (HRT) of 7 h]. The adsorption capacity of F. benjamina wood chips on the metformin and ciprofloxacin was 0.1 and 2.03 µg gsupport material–1, respectively. CONCLUSION The maximum removal rates for metformin, ciprofloxacin, COD and NH3‐N were obtained when the aerated biofilter was operated at HRT = 7 h. The F. benjamina wood chips showed sorption properties of pharmaceuticals. According to a scanning electron microscopy image, the F. benjamina wood chips showed available pores in their entire surface, thus indicating that this organic support medium has a high potential for carrying out the sorption processes. Likewise, the surface of the wood chips showed the development of a homogeneous biofilm. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

García‐Sánchez

Gutiérrez‐Macías

Estrada‐Arriaga

2019

J of Chemical Tech & Biotech

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“…Consequently, a non-steady compound balance allowed for the prediction of the evolution of the pharmaceutical in the bioreactor. From this balance, the time required to ensure the working concentration of pharmaceutical was assessed according to Calero-Díaz et al [12]. To simulate punctual exposures to these pharmaceuticals, once the concentration of pharmaceutical was achieved, the pilot plant was run for 3 days under each doping.…”

Section: Operation Conditionsmentioning

confidence: 99%

“…The concentrations of carbamazepine, ciprofloxacin, and ibuprofen were 100, 10, and 100 µg/L, 1000, 100, and 1000 µg/L, and 5000, 500, and 5000 µg/L in the doping cycles 1, 2, and 3, respectively. The lowest mixing ratio between the different chemicals was based on the average values found in previous studies [12]; once the initial values were chosen, increasing concentrations were used to check the bioreactor by keeping the initial ratio constant. Moreover, this work was also designed to analyze the capacity of the bioreactor to adapt when different concentrations of pharmaceutical mixes were introduced into the biological process.…”

Section: Introductionmentioning

confidence: 99%

Heterotrophic Kinetic Study and Nitrogen Removal of a Membrane Bioreactor System Treating Real Urban Wastewater under a Pharmaceutical Compounds Shock: Effect of the Operative Variables

Monteoliva-García

Leyva‐Díaz

López-López

et al. 2019

Water

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Numerous studies have analyzed the viability of the biodegradation and removal of different compounds of emerging concern in biological systems for wastewater treatment. However, the effect on the heterotrophic biomass of organic matter removal is sometimes missed. The aim of the present research was to study the effect of the addition of a mix of three pharmaceuticals (carbamazepine, ciprofloxacin, and ibuprofen) on the behavior of the biomass in two different membrane-based biological systems treating urban wastewater. The present research studied a membrane bioreactor (MBR) pilot plant operating at a similar mixed liquor suspended solids (MLSS) concentration (about 5.5 g/L). This system works as an MBR and is combined with a moving bed biofilm reactor (MBBR-MBR) to treat real urban wastewater at 6 and 10 h of hydraulic retention time (HRT) under three different shocks of pharmaceuticals with increasing concentrations. In all cases, the organic matter removal was, in average terms, higher than about 92% of biochemical oxygen demand on the fifth day (BOD5), 79% of chemical oxygen demand (COD), and 85% of total organic carbon (TOC). Nevertheless, the removal is higher in the MBBR-MBR technology under the same HRT and the MLSS is similar. Moreover, the removal increased during the shock of pharmaceutical compounds, especially in the MBR technology. From a kinetic perspective, MBBR-MBR is more suitable for low HRT (6 h) and MBR is more effective for high HRT (10 h). This could be due to the fact that biofilm systems are less sensitive to hostile environments than the MBR systems. The removal of N-NH4+ decreased considerably when the pharmaceutical compounds mix was introduced into the system until no removal was detected in cycle 1, even when biofilm was present.

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Activated carbon adsorption for mitigating the harmful effects of antibiotics on the biological activated sludge: Effect on heterotrophic kinetics through respirometry

Díaz,

García‐Menéndez,

Leyva‐Díaz

et al. 2024

Water Environment Research

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Conventional wastewater treatment plants (WWTPs) are not designed for the abatement of antibiotics, and their effluents are one of the main entry ways of these emerging contaminants to the aquatic environment, causing major concern due to their toxicity, persistence, and bioaccumulation. When wastewater containing antibiotics enters the bioreactor, they can impact microbial communities of the activated sludge, affecting biodegradation processes of organic matter and nutrients. There is scarce information about the effect of activated carbon on the activated sludge within the bioreactor in presence of antibiotics. In light of this, the effect of representative antibiotics, ciprofloxacin (CIP), nalidixic acid (NAL), and erythromycin (ERY), on the performance of a conventional activated sludge of a WWTP was analyzed by respirometry with and without activated carbon. NAL and ERY negatively affected the net heterotrophic biomass growth rate (r′x,H), with reduction percentages of 26%–90% and 31%–81%, respectively. The addition of activated carbon mitigated this effect, especially for ERY, with increments of even 8% in the r′x,H for the hybrid process when working with 5 ppm of ERY and 80 ppm of activated carbon compared with the value in the absence of antibiotic and activated carbon. This effect was attributed to the enhanced retention of ERY, in comparison to NAL, on the surface of the activated carbon, probably due to its higher molecular size and affinity towards the activated carbon (log Kow = 3.06). This effect was more marked at low sludge retention times (below 8 days).Practitioner points Ciprofloxacin (CIP), nalidixic acid (NAL), and erythromycin (ERY) were studied. NAL and ERY exerted negative impact on heterotrophic growth rate. Effect of antibiotics on microorganisms in the presence of activated carbon was studied. Activated carbon was mainly relevant for ERY due to its adsorption retention. Enhancement by activated carbon was more significant at low sludge retention times.

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Impact of ciprofloxacin, carbamazepine and ibuprofen on a membrane bioreactor system: Kinetic study and biodegradation capacity

Cited by 20 publications

References 46 publications

Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

Heterotrophic Kinetic Study and Nitrogen Removal of a Membrane Bioreactor System Treating Real Urban Wastewater under a Pharmaceutical Compounds Shock: Effect of the Operative Variables

Activated carbon adsorption for mitigating the harmful effects of antibiotics on the biological activated sludge: Effect on heterotrophic kinetics through respirometry

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