The COVID-19 pandemic has created unprecedented human health crisis in recent global history with rippling social and economic effects. The outbreak in India has resulted in emergency lockdown in the country for more than 2 months, and that caused decline in the catch, demand, and supply of fish. It has severely altered the life and livelihoods of the floodplain wetland fishers. These floodplain wetlands play a key role in socio-economic development of stakeholders, by generating employment and livelihood in the studied regions. In the present study, a systematic assessment was conducted to identify the impact of lockdown on floodplain wetland fisheries in India with the aim to evaluate the impact of the COVID-19 lockdown on wetland fishing, fisheries production, income, and food access. We conducted a rapid telephonic survey covering176 wetland fishers in 3 states to document the early impacts of the pandemic and policy responses on floodplain wetland fisher households. The majority of fishers report negative impacts on production, sales, and incomes. Fishers of three Indian states Bihar, West Bengal, and Assam lost 20, 25, and 9 fishing days, respectively. About 70, 60, and 55 % fishers of floodplain wetlands of the three states admitted that lockdown made them partially jobless. Fish harvest during March to May was 32, 44, and 20 % lower than the previous years in Bihar, West Bengal, and Assam. The fishers of Bihar, West Bengal, and Assam lost income of INR 10000/-, 12500/-, and 4500/- due to lockdown. The analysis also showed that 25% of fishers each responded moderate to severe psychological impact and anxiety symptoms due to COVID-19. Demand supply gap during the lockdown led to the in 20–40 % increase in farm gate price of fishes at the wetland level. The present study is the first of its kind in India to systematically assess the impact and discusses several magnitudes on floodplain wetland fisher livelihood, income, and food access and suggests strategies and decision support.