In recent years, the effects of climate change have become more noticeable in Iran, especially in big cities. In particular, climate-related flood risk is increasingly recognized as a potential threat in the capital city of Tehran. Accordingly, the present study aimed to provide a framework/assessment tool to measure Tehran’s resilience to flood risks. To this end, 21 professionals from different disciplines were selected through a purposive sampling procedure and were interviewed using semi-structured interviews. The analysis procedure resulted in the identification of 3 themes, 15 categories, 40 subcategories, and 235 codes. The themes were social, economic, and organizational; The identified categories were culture and education (since culture is something to be learned through formal and informal education this component has two features: culture and education), participation, trust, attitude, solidarity, resources, empowerment, flexibility, credit, supervision, intercommunication, rules, specialization, and research. Validation of the indicators and their usability based on the opinions of local experts was used to calibrate the assessment tool and ensure its context-sensitivity. The results of this research can help planners and policymakers to increase their awareness of flood resilience. The approach taken in this research may also be useful for developing flood resilience assessment tools in other Iranian cities as well as in other cities of the Global South with similar conditions.