Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals

Langebeek, Nienke; Kooij, Katherine W.; Wit, Ferdinand W; Stolte, Ineke G.; Sprangers, Mirjam A. G.; Reiss, Peter; Nieuwkerk, Pythia T.

doi:10.1097/qad.0000000000001511

Cited by 71 publications

(69 citation statements)

References 33 publications

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“…A summary count of physical comorbidities was calculated. Mental illness was excluded from the count of comorbidities and evaluated as a single dichotomous variable, because HIV may impact mental health and mental health may worsen HRQOL through different mechanisms than physical comorbidities . Two survey items, “What is your race?” and “are you Spanish/Hispanic/Latino?” were collapsed and dichotomized as white/non‐Hispanic versus all other identities.…”

Section: Methodsmentioning

confidence: 99%

“…GBM living with HIV also experience less social support, a greater risk of social isolation, and higher distress resulting from HIV‐related stigma compared with non‐GBM living with HIV . Previous studies have found that people living with HIV have worse physical and mental HRQOL and an increased likelihood of depression than HIV‐negative individuals . In addition, the combination of HIV infection and comorbid conditions may result in even poorer HRQOL …”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have found that people living with HIV have worse physical and mental HRQOL and an increased likelihood of depression than HIV‐negative individuals . In addition, the combination of HIV infection and comorbid conditions may result in even poorer HRQOL …”

Section: Introductionmentioning

confidence: 99%

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Health‐related quality of life by human immunodeficiency virus status in a cross‐sectional survey of gay and bisexual prostate cancer survivors

et al. 2019

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Objective Prostate cancer is the most common invasive cancer in gay and bisexual men (GBM). Despite the unique sexual and urinary concerns of this group, studies of prostate cancer rehabilitation have primarily focused on heterosexual men. GBM also have high prevalence of human immunodeficiency virus (HIV), which may be associated with lower health‐related quality of life (HRQOL). We examined the association between HIV status and HRQOL in a cohort of GBM with prostate cancer. Methods Data from the Restore study, a cross‐sectional online survey of GBM treated for prostate cancer, were used to examine this association. The Expanded Prostate Cancer Index Composite (EPIC) assessed function, bother, and summary measures in four domains: urinary, sexual, bowel, and hormone. Overall physical and mental HRQOL was assessed using the Short‐Form Health Survey (SF‐12). Multivariate analysis of variance and linear regression were used to evaluate the association between HIV status and HRQOL scores after adjustment for demographic and sexual characteristics. Results Of 192 participants, 24 (12.4%) reported an HIV diagnosis. After adjustment for covariates, HIV‐positive status was associated with lower scores on the EPIC urinary (mean difference [MD]: −13.0, 95% CI, −21.4 to −4.6), sexual (MD: −12.5, 95% CI, −21.9 to −3.2), and bowel (MD: −5.9, 95% CI, −11.7 to −0.2) domains. No significant associations were observed between HIV status and other outcomes. Conclusions HIV status may be associated with poorer urinary, sexual, and bowel HRQOL in GBM prostate cancer survivors.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Health‐related quality of life by human immunodeficiency virus status in a cross‐sectional survey of gay and bisexual prostate cancer survivors

et al. 2019

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“…Considering a longer life expectancy, the care and treatment of PLWHA should focus not only on continued medical treatment improvements but also on the individual’s quality of life. Prior research shows that PLWHA report lower health-related quality of life (QOL) and a higher prevalence of depression relative to the general population (13) and individuals uninfected with HIV (12). Furthermore, QOL is associated with poor clinical outcomes such that individuals who report lower QOL also have lower CD4 counts (14).…”

Section: Introductionmentioning

confidence: 99%

Mindfulness-Based Interventions for Adults Living with HIV/AIDS: A Systematic Review and Meta-analysis

et al. 2018

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This meta-analysis examined the effects of mindfulness-based interventions (MBIs) on stress, psychological symptoms, and biomarkers of disease among people living with HIV/AIDS (PLWHA). Comprehensive searches identified 16 studies that met the inclusion criteria (N = 1059; M age = 42 years; 20% women). Participants had been living with HIV for an average of 8 years (range = < 1-20 years); 65% were currently on antiretroviral therapy. Between-group analyses indicated that depressive symptoms were reduced among participants receiving the MBIs compared to controls (d+ = 0.37, 95% CI 0.03, 0.71). Within-group analyses showed reductions in psychological symptoms (i.e., less anxiety, fewer depressive symptoms) and improved quality of life over time among MBI participants (d+s = 0.40-0.85). No significant changes were observed for immunological outcomes (i.e., CD4 counts) between- or within-groups. MBIs may be a promising approach for reducing psychological symptoms and improving quality of life among PLWHA. Studies using stronger designs (i.e., randomized controlled trials) with larger sample sizes and longer follow-ups are needed to clarify the potential benefits of MBIs for PLWHA.

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“…The presence -of neuropsychiatry co-morbidity in the pathophysiology of HIV compounds the suffering and detrimental prognosis of those afflicted with a complex relationship between HIV infection and psychiatric co-morbidity [4,5]. For example, HIV-positive status was significantly and independently associated with worse physical and mental health-related qualityof life and with an increased likelihood of depression [6]. Heroin administration, with or without smoking and cannabis, has emerged as a significantly destructive dimension of the HIV epidemic in Kenya [7].…”

Section: Editorialmentioning

confidence: 99%

Drug Use and Abuse in HIV

Archer¹

2017

HIV Curr Res

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Impact of comorbidity and ageing on health-related quality of life in HIV-positive and HIV-negative individuals

Cited by 71 publications

References 33 publications

Health‐related quality of life by human immunodeficiency virus status in a cross‐sectional survey of gay and bisexual prostate cancer survivors

Health‐related quality of life by human immunodeficiency virus status in a cross‐sectional survey of gay and bisexual prostate cancer survivors

Mindfulness-Based Interventions for Adults Living with HIV/AIDS: A Systematic Review and Meta-analysis

Drug Use and Abuse in HIV

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