Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer

Abstract

Purpose The principal goal of treatment of laryngeal cancer is to eliminate a tumour while preserving laryngeal function with radio(chemo)therapy being the mainstay of treatment. The aim of this report is to present the influence of comorbidities and lifestyle factors on treatment outcomes in our cohort of patients. Methods During the period 2009–2018, curative radio(chemo)therapy for laryngeal cancer was performed on 189 patients. Results The median OS was 50.8 months, with a mean PFS of 96.5 months, mean LC of 101.4 months and a median follow-up of 38.1 months. Acute and late treatment toxicity grade 3–4 was observed in 39.2% patients and 10.1% patients, respectively. A significant effect on overall survival was confirmed for the baseline PS (performance status), severity of weight loss, baseline haemoglobin values, history of alcohol abuse, marital status and comorbidities according to the Charlson Comorbidity Index, as well as the ACE-27 and ASA scores. Conclusions In our cohort of patients treated with radio(chemo)therapy for laryngeal cancer, we found good therapeutic results and an acceptable side-effect profile. Statistically significant predictors of overall survival were the baseline PS, weight loss, anaemia, associated comorbidities, history of alcohol abuse and marital status.

Survival Outcomes in T3 Laryngeal Cancers: Primary Total Laryngectomy vs. Concurrent Chemoradiation or Radiation Therapy—A Meta-Analysis

“…Tangsriwong et al [ 55 ] found that N category, volume of primary, vocal cord involvement, dose of RT, and radiation treatment gap exceeding seven days were identified as factors that significantly influenced laryngeal preservation. Pechacova et al [ 56 ] reported that baseline performance status, weight loss, comorbidities, coexisting anaemia, history of alcohol intake, and marital status were predictors of OS in patients receiving CRT for laryngeal cancer. Sherman et al identified that patients with T stage tumours (T4), serum albumin (<4 g/dL), alcohol use (≥6 drinks/day), and Karnofsky’s score (<80) had significantly decreased rates of larynx preservation [ 57 ].…”

The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP

“…The fact that UD-SSC-2 as an HPV-positive cell line was more resistant to treatment with Xevinapant suggests that it may have a greater effect on HPV-negative cells, but the stronger cytotoxicity on the other HPV-positive cell line, UM-SSC-47, does not support this idea. Because RT also affects the surrounding healthy tissue and can cause side effects on skin, mouth and throat, two healthy cell lines were studied to examine possible effects of Xevinapant and IR on healthy tissue cells [ 69 , 70 ]. The skin fibroblasts SBLF9 were clearly less affected by treatment with Xevinapant alone and in combination with IR than the malignant cell lines.…”