Impact of Completion Lymphadenectomy on Quality of Life for Head and Neck Cutaneous Melanoma

Farlow, Janice L.; McLean, Scott A.; Peddireddy, Nithin S.; Bradford, Carol R.; Malloy, Kelly M.; Stucken, Chaz L.; VanKoevering, Kyle K.; Spector, Matthew E.; Rosko, Andrew J.

doi:10.1177/01945998211007442

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…While various tests for the assessment of QoL have been published in the literature, only one provides a focused analysis of the effects of ND on QoL. The NDII questionnaire was developed by Chepeha et al in 2002 and since then it has been used in several studies in English-speaking populations 4 , 12 , 13 . The questionnaire has also been used as a comparison for the validation of less specific instruments, such as the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire for use in patients after ND for head and neck cancer 14 .…”

Section: Discussionmentioning

confidence: 99%

Italian validation of the Neck Dissection Impairment Index questionnaire

Marcuzzo

Sacchet

Capriotti

et al. 2022

Acta Otorhinolaryngol Ital

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SUMMARY Objective The Neck Dissection Impairment Index (NDII) questionnaire is a useful and validated Quality of Life (QoL) evaluation instrument in patients undergoing major head-neck surgery. Its English version has been used in several studies in the last years. The aim of this work is to validate the NDII in Italian for both patient assessment and future studies. Materials and methods Cross-cultural adaptation of the NDII was performed using standard techniques. Items of the original NDII were translated into Italian by a professional translator and two bilingual investigators. A final consensus version was obtained and given to two professional translators to produce a literal translation into English. The two translators and an expert committee synthesised the results of the translations in an English back-translated version that was compared with the original to check that they had the same semantic value. Results Finally, a total of 42 patients completed both copies of the translated questionnaires. Internal consistency proved to be excellent, with Cronbach’s alpha = 0.95. Conclusions The NDII was successfully translated into Italian and its use was easy for patients. The translation of the NDII can represent a useful tool for individual patient assessment and future research.

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Section: Discussionmentioning

confidence: 99%

Italian validation of the Neck Dissection Impairment Index questionnaire

Marcuzzo

Sacchet

Capriotti

et al. 2022

Acta Otorhinolaryngol Ital

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“…However, it remains unclear whether there is a difference in prognosis between elective neck dissection (END) or elective neck irradiation (ENI). Furthermore, potential adverse impacts on quality of life (QoL) resulting from neck management - such as shoulder dysfunction following END or xerostomia after ENI - need to be considered [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Elective neck dissection versus elective neck irradiation in cT3/4N0 maxillary sinus squamous cell carcinoma: a propensity score matching analysis

Chen,

Gu,

Xuan

et al. 2024

World J Surg Onc

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Background Maxillary sinus squamous cell carcinoma (MS-SCC) is an infrequent malignancy, and determining the optimal neck management for patients with cT3/4N0 MS-SCC remains a topic of ongoing debate. The purpose of this study was to compare the prognoses and quality of life outcomes of patients who underwent either elective neck dissection (END) or elective neck irradiation (ENI) for cT3/4N0 MS-SCC. Methods In this retrospective study, we enrolled patients with surgically treated cT3/4N0 MS-SCC, and the impact of different neck management strategies on regional control and disease-specific survival was compared using propensity score matching. The effect of surgical intervention on quality of life was evaluated using the Mann-Whitney U test. Results Of the 120 patients included, 36 underwent END. After propensity score matching, our analysis indicated that END did not lead to superior outcomes than ENI, as demonstrated by comparable rates of regional control (p = 0.990) and disease-specific survival (p = 0.999). However, in the 70 returned questionnaires, patients who underwent END reported higher scores in the domains of appearance, chewing, and speech than did patients who underwent ENI. Conclusions Our findings suggest that while END and ENI contribute to similar prognoses, END yields superior functional outcomes.

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Impact of Adjuvant Interferon Therapy on Survival Outcomes for Cutaneous Melanoma With Parotid Involvement

Kim,

Raven,

Lenze

et al. 2024

The Laryngoscope

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ObjectivesTo determine the relative 5‐year overall survival (OS) and 5‐year recurrence‐free survival (RFS) outcomes for adjuvant interferon therapy in the treatment of head and neck cutaneous melanoma (HNCM) with parotid gland involvement.MethodsA retrospective cohort study was conducted at a single tertiary care institution to analyze patients undergoing parotidectomy for cutaneous head and neck melanoma involving the parotid gland from 2000 to 2014. Time‐to‐event analyses were performed using Kaplan–Meier curves with log‐rank p‐values and Cox proportional hazards models.ResultsThe sample consisted of 82 patients who underwent surgical resection of stage III HNCM with parotid involvement. The mean follow‐up was 67.8 months (SD 65) after diagnosis. Twenty‐one patients received adjuvant interferon therapy, 12 patients received adjuvant radiation therapy, and 49 patients received no adjuvant therapy. Crude 5‐year OS rates were 95.0% for interferon therapy, 33.3% for adjuvant RT, and 40.4% for no adjuvant therapy. Crude 5‐year RFS rates were 75.2%, 19.5%, and 40.8% respectively. In the fully adjusted model, adjuvant interferon therapy was associated with improved 5‐year OS compared to adjuvant RT (HR 0.10, 95% CI 0.011–0.837; p = 0.034). There was no significant association between adjuvant interferon therapy and 5‐year RFS in the fully adjusted model.ConclusionAdjuvant interferon therapy for surgically resected stage III cutaneous melanoma with parotid gland involvement may be associated with improved survival outcomes. These findings support the growing evidence for the use of immunotherapy in melanoma, and potentially a unique role for when melanoma involves the lymphatic‐rich parotid gland.Level of Evidence3 Laryngoscope, 2024

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Impact of Completion Lymphadenectomy on Quality of Life for Head and Neck Cutaneous Melanoma

Cited by 6 publications

References 31 publications

Italian validation of the Neck Dissection Impairment Index questionnaire

Italian validation of the Neck Dissection Impairment Index questionnaire

Elective neck dissection versus elective neck irradiation in cT3/4N0 maxillary sinus squamous cell carcinoma: a propensity score matching analysis

Impact of Adjuvant Interferon Therapy on Survival Outcomes for Cutaneous Melanoma With Parotid Involvement

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