Impact of computed tomography and 18F-deoxyglucose coincidence detection emission tomography image fusion for optimization of conformal radiotherapy in non–small-cell lung cancer

Deniaud-Alexandre, É.; Touboul, E.; Lerouge, D.; Grahek, D.; Foulquier, J.N.; Petegnief, Yolande; Grès, B. Du; Balaa, Hanna El; Keraudy, K.; Kerrou, K.; Montravers, F.; Milleron, B.; Lebeau, B.; Talbot, Jean-Noël

doi:10.1016/j.ijrobp.2005.05.016

Cited by 111 publications

(90 citation statements)

References 41 publications

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“…In NSCLC movement with respiration can be dramatic [63]. Motion can be compensated for by gating, which PET/CT [71] is best but PET/CT image coregistration, ideally using fiducial markers, can be used [72].…”

Section: Tumor Movementmentioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

334

197

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Section: Tumor Movementmentioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

334

197

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“…CT-MRI fusion should be considered for RT planning wherever possible, especially when delineating gross tumour volume (GTV), particularly in central nervous system and skull base tumours. Initial studies using 18-F fludeoxyglucose-positron emission tomography (FDG-PET), which highlights the proliferating areas of the tumour, have been reported [67] and have shown that FDG-PET can aid delineation of the GTV [68][69][70][71][72][73]. Detailed clinical and radiological assessment of the tumours should be undertaken to ensure that the entire microscopic disease is encompassed in the high-dose CTV1.…”

Section: Target Volume Delineationmentioning

confidence: 99%

Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers

Bhide

Newbold²,

Harrington³

et al. 2012

BJR

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ABSTRACT. Radiotherapy and surgery are the principal curative modalities in treatment of head and neck cancer. Conventional two-dimensional and three-dimensional conformal radiotherapy result in significant side effects and altered quality of life. Intensity-modulated radiotherapy (IMRT) can spare the normal tissues, while delivering a curative dose to the tumour-bearing tissues. This article reviews the current role of IMRT in head and neck cancer from the point of view of normal tissue sparing, and also reviews the current published literature by individual head and neck cancer subsites. In addition, we briefly discuss the role of image guidance in head and neck IMRT, and future directions in this area. Intensity-modulated radiotherapy (IMRT) is an advanced approach to three-dimensional (3D) treatment planning and conformal therapy. It optimises the delivery of irradiation to irregularly shaped volumes and has the ability to produce concavities in radiation treatment volumes. For head and neck cancer, the clinical target volume 1 (CTV1), which includes the primary tumour and the involved nodes, typically receives a higher radiation dose than CTV2. The different doses to CTV1 and 2 can be delivered simultaneously, while sparing the parotid salivary glands and the spinal cord. In the head and neck region, IMRT has a number of potential advantages: (i) it allows for greater sparing of normal structures such as salivary glands, oesophagus, optic nerves, brain stem and spinal cord [7,8]; (ii) it allows treatment to be delivered in a single treatment phase without the requirement for matching additional fields to provide tumour boosts, and eliminates the need for electron fields to the posterior (levels II and V) neck nodes; and (iii) it offers the possibility of simultaneously delivering higher radiation doses to regions of gross disease and lower doses to areas of microscopic disease-the so-called simultaneous integrated boost (SIB) IMRT [9].IMRT can be delivered using linear accelerators with static multileaf collimators (MLCs; step and shoot IMRT) or dynamic leaf MLCs, tomotherapy machines or volumetric modulated arc therapy (VMAT). Tomotherapy enables the simultaneous use of image guidance and treatment delivery [10]. However, adaptive RT based on image guidance is yet to be clinically optimised in head and neck cancer. VMAT is a newer technique of delivering IMRT. VMAT delivers IMRT-like distributions in a single rotation of the gantry, varying the gantry speed and dose rate during delivery, in contrast to standard IMRT, which uses fixed gantry beams. Planning studies using RT demonstrate shorter planning and treatment time, fewer monitor units for treatment delivery and better dose homogeneity and normal tissue sparing [11,12]. There is a lack of data as regards clinical implementation of this technique.IMRT was first described in 1999; in the last decade numerous retrospective case series (single and multiinstitution) and a few randomised trials have been published studying the clinical implementation of thi...

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“…It is expected that the combined use of CT and the functional information from 18 F-FDG PET will lead to improved tumor delineation (1)(2)(3)(4)(5)(6)(7)(8)(9). However, until now, tumor delineation using PET has been based on static images of 18 F-FDG uptake obtained at a fixed time after injection.…”

mentioning

confidence: 99%

Comparison of Tumor Volumes Derived from Glucose Metabolic Rate Maps and SUV Maps in Dynamic ¹⁸F-FDG PET

Visser¹,

Philippens²,

Kienhorst³

et al. 2008

J Nucl Med

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Tumor delineation using noninvasive medical imaging modalities is important to determine the target volume in radiation treatment planning and to evaluate treatment response. It is expected that combined use of CT and functional information from 18 F-FDG PET will improve tumor delineation. However, until now, tumor delineation using PET has been based on static images of 18 F-FDG standardized uptake values (SUVs). 18 F-FDG uptake depends not only on tumor physiology but also on blood supply, distribution volume, and competitive uptake processes in other tissues. Moreover, 18 F-FDG uptake in tumor tissue and in surrounding healthy tissue depends on the time after injection. Therefore, it is expected that the glucose metabolic rate (MR glu ) derived from dynamic PET scans gives a better representation of the tumor activity than does SUV. The aim of this study was to determine tumor volumes in MR glu maps and to compare them with the values from SUV maps. Methods: Twenty-nine lesions in 16 dynamic 18 F-FDG PET scans in 13 patients with non-small cell lung carcinoma were analyzed. MR glu values were calculated on a voxel-by-voxel basis using the standard 2-compartment 18 F-FDG model with trapping in the linear approximation (Patlak analysis). The blood input function was obtained by arterial sampling. Tumor volumes were determined in SUV maps of the last time frame and in MR glu maps using 3-dimensional isocontours at 50% of the maximum SUV and the maximum MR glu , respectively. Results: Tumor volumes based on SUV contouring ranged from 1.31 to 52.16 cm 3 , with a median of 8.57 cm 3 . Volumes based on MR glu ranged from 0.95 to 37.29 cm 3 , with a median of 3.14 cm 3 . For all lesions, the MR glu volumes were significantly smaller than the SUV volumes. The percentage differences (defined as 100% · (V MR glu 2 V SUV )/V SUV , where V is volume) ranged from 212.8% to 284.8%, with a median of 232.8%. Conclusion: Tumor volumes from MR glu maps were significantly smaller than SUV-based volumes. These findings can be of importance for PET-based radiotherapy planning and therapy response monitoring.

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Impact of computed tomography and 18F-deoxyglucose coincidence detection emission tomography image fusion for optimization of conformal radiotherapy in non–small-cell lung cancer

Cited by 111 publications

References 41 publications

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers

Comparison of Tumor Volumes Derived from Glucose Metabolic Rate Maps and SUV Maps in Dynamic ¹⁸F-FDG PET

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Impact of computed tomography and 18F-deoxyglucose coincidence detection emission tomography image fusion for optimization of conformal radiotherapy in non–small-cell lung cancer

Cited by 111 publications

References 41 publications

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers

Comparison of Tumor Volumes Derived from Glucose Metabolic Rate Maps and SUV Maps in Dynamic 18F-FDG PET

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Comparison of Tumor Volumes Derived from Glucose Metabolic Rate Maps and SUV Maps in Dynamic ¹⁸F-FDG PET