Impact Of Concentrated Growth Factors(CGF) On Clinical outcomes Of Immediately Loaded Dental Implants In Controlled Diabetic Patients

Abstract

Problem statement Diabetes mellitus is considered as a relative contraindication to dental implant therapy. Meanwhile, different platelet concentrates are thought to have a positive impact on implant success. This study was conducted to assess the impact of concentrated growth factors(CGF) on clinical outcomes of immediately loaded dental implants in controlled diabetic patients. Patient and Method: Sixteen patients seeking for dental implants were divided into the following groups. Negative control group included four healthy nondiabetic patients (HbA1c < 6%) without application of CGF prior to implant insertion. While, twelve well controlled diabetic patients (HbA1c 6.1-8 %) were furtherly and randomly distributed into two equal groups: Positive control group (2 nd group) included six well controlled diabetic patients (HbA1c 6.1-8 %) without application of CGF prior to implant insertion. The Study group (3 rd group) included six well controlled diabetic patients (HbA1c 6.1-8 %) with application of CGF prior to implant insertion. All implants were subjected to immediate loading within (48-72) hours after fixture installation. All patients were assessed clinically either at baseline (T0), 6 months (T1) or at 12 months (T2) of follow up regarding to implant stability, Modified sulcus bleeding index and peri-implant probing depth and radiographically for assessment of crestal bone loss (CBL). Result: There were no significant differences between all groups regarding implant at different time intervals of follow up periods either at, (T0), (T1), (T2) (P=0.285, 0.326, 0.341 respectively). However, within the positive control group Statistical significant differences were recorded between (T0) values and those values recorded at (T1) and (T2) (P=0.021, 0.004 respectively). No significant differences were recorded between all groups regarding to mSBI, CBL and PIPD at different time intervals of follow up periods either at, (T0), (T1), and (T2) (P=0.822, 0.211, 0.149 respectively). (P=1.000, 0.367, 0.132 respectively). (P=0.822, 0.211, 0.149 respectively). Conclusion: Dental implants can be immediately loaded in controlled diabetic patients with acceptable outcomes. Meanwhile, CGF can positively improve implant stability in controlled diabetic patients especially within the early critical phase of healing.