2020
DOI: 10.21203/rs.3.rs-38047/v2
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Impact of concomitant systemic treatments on toxicity and intracerebral response after stereotactic radiotherapy for brain metastases 

Abstract: Background: The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM). Methods: 99 patients (171 BM) received SRT and concurrent ST (group 1) and 95 patients (131 BM) received SRT alone without concurrent ST (group 2). SRT was planned on a linear accelerator, using volumetric modulated arc therapy. All ST were allowed including chemotherapy (CT), immunotherapy (IT), targeted therapy (TT) a… Show more

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