Impact of consanguinity on spontaneous pregnancy loss and descendants’ health in north Morocco

Abstract

PurposeThe present study aims to bring out the impact of consanguinity on spontaneous pregnancy loss (SPL) and on descendants’ health, among the population of north Morocco.Design/methodology/approachConvenience sampling was used for collecting data. A questionnaire was randomly administered to 385 couples represented by either the husband, the wife or both. The study lasted for three months, from January to March 2015.FindingsIn total, 238 valid questionnaires were analysed. The results showed that the consanguinity rate was 45.23% and that most consanguineous unions were between first cousins (91%). Data analysis revealed that SPL risk was similar in consanguineous and non-consanguineous couples (OR = 1.6; IC95% = 0.9–2.9). Also, no significant difference was observed in terms of SPL type (OR = 1.6; IC95% = 0.7–3.9) and frequency (p = 0.81). However, late SPL frequency was significantly lower in consanguineous couples (p < 0.001), whereas no significant difference was registered in terms of early SPL frequency (p = 0.73). On the other hand, consanguineous couples displayed a significantly higher risk of descendants’ health disorders in comparison with non-consanguineous ones. Moreover, the consanguineous couples had a significantly higher number of children with health disorders (p < 0.001). The risk analysis also showed that consanguineous couples displayed a significantly higher risk of congenital malformations (OR = 7.23; IC95% = 3.52–14.84) and multifactorial diseases (OR = 3.72; IC95% = 1.46–9.49), but no significant difference was observed in terms of behavioural disorders risk.Originality/valueThe population awareness regarding the negative effects of consanguinity should be raised through education programmes and premarital, prenatal and genetic counselling services.

Youth consanguinity in relation to sociodemographic and women-related fertility factors in the Arab society of Israel

“…A study from Lebanon found that total pregnancies, live births, and living children were significantly higher among consanguineous couples than among nonconsanguineous ones [58]. Additionally, a recent study from Morocco revealed that the frequency of late spontaneous pregnancy loss (SPL) was significantly lower in consanguineous couples [59]. Another study form Pakistan revealed that the couples with CMs were found to exhibit greater fertility than nonconsanguineous couples, this is in terms of abortions/miscarriages, stillbirths, and deaths in the infants [60,61].…”