Impact of Conservative Managements in Young Women With Grade 2 or 3 Endometrial Adenocarcinoma Confined to the Endometrium

Gonthier, Clémentine; Trefoux-Bourdet, A.; Koskas, Martin

doi:10.1097/igc.0000000000000895

Cited by 25 publications

(24 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, 33 were excluded for various reasons, leaving 10 retrospective cohort studies to perform our meta-analysis [ 10 – 19 ]. We dropped one study because it might comprise the same study population as two other studies from the USA, although the data was extracted from a different database [ 11 , 19 , 20 ]. We chose to keep the two studies that analyzed data from the Surveillance, Epidemiology, and End Results program (SEER) rather than the one from the National Cancer Database ( NCDB ) due to their longer follow-up duration [ 11 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…We dropped one study because it might comprise the same study population as two other studies from the USA, although the data was extracted from a different database [ 11 , 19 , 20 ]. We chose to keep the two studies that analyzed data from the Surveillance, Epidemiology, and End Results program (SEER) rather than the one from the National Cancer Database ( NCDB ) due to their longer follow-up duration [ 11 , 19 ]. We dropped another study from Taiwan because it contained patients over the upper age limit [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer

Jia

Zhang

2017

Oncotarget

View full text Add to dashboard Cite

We searched Medline, Embase, Cochrane library, the Chinese Biomedicine Literature Database, the Chinese Scientific Journal Full-text Database, the Chinese Journal Full-text Database, and the Wanfang Database to collect observational studies on the effects of ovary-saving surgery in comparison to bilateral salpingo-oophorectomy (BSO) in young patients with early-stage endometrial cancer (EC). The literature search included studies up to March 2017, and 10 retrospective cohort studies met our selection criteria. Random and fixed effect models revealed that ovarian preservation (OP) was associated with better overall survival (OS) (hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.57–0.99, P = 0.044), and was not associated with reduced recurrence-free survival (RFS) in pre-menopausal patients with early-stage endometrial cancer (HR 1.22, 95% CI 0.32–4.72, P = 0.648; risk ratio [RR] 1.11, 95% CI 0.59–2.10, P = 0.745). Preservation of the ovaries appears to be a safe option with significant benefit for this low risk population after a thorough preoperative evaluation and extensive intraoperative exploration.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer

Jia

Zhang

2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Few studies reported the safety of fertility‐sparing management of grade 2 endometrial cancer . However, a recent large retrospective analysis reported an increased risk associated with uterine preservation in patients with grade 2 and 3 endometrial adenocarcinoma and suggested such management should be limited in time . Equivocal lesions should be examined by an experienced pathologist.…”

Section: Special Considerationsmentioning

confidence: 99%

“…In premenopausal women with low-grade early stage disease, ovarian preservation could be considered. 29,30 Vaginal cuff removal is not advised, nor is there any benefit from excising parametrial tissue in the usual case. Where obvious cervical stromal involvement is demonstrated preoperatively, a modified radical hysterectomy has been historically performed.…”

Section: Surgical Staging Procedures For Endometrial Cancermentioning

confidence: 99%

See 1 more Smart Citation

Cancer of the corpus uteri

Amant

Mirza

Koskas³

et al. 2018

Intl J Gynecology & Obste

Self Cite

333

231

View full text Add to dashboard Cite

Endometrial cancer is the most common gynecological malignancy in high‐income countries. Although the overall prognosis is relatively good, high‐grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Standard treatment consists of hysterectomy and bilateral salpingo‐oophorectomy. Lymphadenectomy (with ongoing studies of sentinel node biopsy) enables identification of lymph node positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant radiotherapy is used for Stage I–II patients with high‐risk factors and Stage III lymph node negative patients. In advanced disease, a combination of surgery to no residual disease and chemotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease‐free interval.

show abstract

Cancer of the corpus uteri: 2021 update

Koskas¹,

Amant

Mirza

et al. 2021

Intl J Gynecology & Obste

Self Cite

208

116

View full text Add to dashboard Cite

Endometrial cancer is the most common gynecological malignancy in high‐ and middle‐income countries. Although the overall prognosis is relatively good, high‐grade endometrial cancers have a tendency to recur. Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Since The Cancer Genome Atlas defined four molecular subgroups of endometrial cancers, the molecular factors are increasingly used to define prognosis and treatment. Standard treatment consists of hysterectomy and bilateral salpingo‐oophorectomy. Lymphadenectomy (and increasingly sentinel node biopsy) enables identification of lymph node‐positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant therapy is used for Stage I–II patients with high‐risk factors and Stage III patients; chemotherapy is especially used in non‐endometrioid cancers and those in the copy‐number high molecular group characterized by TP53 mutation. In advanced disease, a combination of surgery to no residual disease and chemotherapy with or without radiotherapy results in the best outcome. Surgery for recurrent disease is only advocated in patients with a good performance status with a relatively long disease‐free interval.

show abstract

Impact of Conservative Managements in Young Women With Grade 2 or 3 Endometrial Adenocarcinoma Confined to the Endometrium

Abstract: Ovarian preservation has no impact on survival probability in patients with grade 2 or 3 endometrial cancer confined to the endometrium. On the contrary, physicians and patients should be aware of the worse prognosis associated with uterine preservation.

Cited by 25 publications

References 26 publications

Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer

Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer

Cancer of the corpus uteri

Cancer of the corpus uteri: 2021 update

Contact Info

Product

Resources

About