Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits

Abstract

This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T 3 and T 4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits. ‫ـــــــــــــــــــــــــــــــــــــــــ‬

Evaluation of the hepatoprotective role of ethanolic Saussurea lappa root extract in female rats experimentally exposed to propylthiouracil

“…In addition, the current study's histopathological examination revealed several abnormalities in the liver tissue of GII animals. These results are in agreement with [23,27]. The PTU is commonly used to induce hypothyroidism experimentally [28].…”

Pathophysiological effects of Tamiflu on liver and kidneys of male rats

“…While Farrag et al . [ 33 ] explained that the drug caused the changes should be listed among “drugs-induced liver injury”. The latter type of drugs defined as “drug-induced critical alterations of hepatocytes that trigger the immune systems of susceptible hosts to infiltrate their livers and assault/damage hepatocytes, which leads to liver injury”.…”