Impact of contrast enhanced MRI on lymphocyte DNA damage and serum visfatin level

Yıldız, Sema; Çeçe, Hasan; Kaya, Ihsan; Çelik, Hakim; Taşkın, Abdullah; Aksoy, Nurten; Koçyiğit, Abdürrahim; Eren, Mehmet Ali

doi:10.1016/j.clinbiochem.2011.05.005

Cited by 34 publications

(21 citation statements)

References 35 publications

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“…4 Co-genotoxic effects of MR in combination with the administered gadolinium-based contrast material may further have contributed to DNA damage due to the potentiating effect of gadolinium-based contrast material and MR exposure. 31 As in our study all patients underwent contrast enhanced CMR, reflecting widely used clinical practice, 32 we cannot differentiate the precise contribution of the known genotoxic effect of the gadolinium-based contrast material from the effects of the magnetic field. However, the use of contrast material is generally an integrated part of CMR scanning and therefore our results may appropriately represent the effect of a routine CMR scan.…”

Section: Discussionmentioning

confidence: 88%

Impact of cardiac magnetic resonance imaging on human lymphocyte DNA integrity

Fiechter

Stehli

Fuchs

et al. 2013

European Heart Journal

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AimsMagnetic resonance (MR) imaging is widely used for diagnostic imaging in medicine as it is considered a safe alternative to ionizing radiation-based techniques. Recent reports on potential genotoxic effects of strong and fast switching electromagnetic gradients such as used in cardiac MR (CMR) have raised safety concerns. The aim of this study was to analyse DNA double-strand breaks (DSBs) in human blood lymphocytes before and after CMR examination.Methods and resultsIn 20 prospectively enrolled patients, peripheral venous blood was drawn before and after 1.5 T CMR scanning. After density gradient cell separation of blood samples, DNA DSBs in lymphocytes were quantified using immunofluorescence microscopy and flow cytometric analysis. Wilcoxon signed-rank testing was used for statistical analysis. Immunofluorescence microscopic and flow cytometric analysis revealed a significant increase in median numbers of DNA DSBs in lymphocytes induced by routine 1.5 T CMR examination.ConclusionThe present findings indicate that CMR should be used with caution and that similar restrictions may apply as for X-ray-based and nuclear imaging techniques in order to avoid unnecessary damage of DNA integrity with potential carcinogenic effect.

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Section: Discussionmentioning

confidence: 88%

Impact of cardiac magnetic resonance imaging on human lymphocyte DNA integrity

Fiechter

Stehli

Fuchs

et al. 2013

European Heart Journal

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“…In contrast, statistically significant enhancements were observed by Lee et al 19 following in vitro exposure times of 45 min or greater, with the observed level increasing with duration of exposure. For in vivo exposures, Yildiz et al 20 observed no significant increase in lymphocytes taken after the initial non-contrast-enhanced MRI. However, they did report a significant increase in the lymphocytes taken following the subsequent contrast-enhanced MRI.…”

Section: Does Mri Exposure Lead To Dna Damage?mentioning

confidence: 99%

Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity

Hill

O’Neill

McKenna

2016

Eur Heart J Cardiovasc Imaging

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Magnetic resonance imaging (MRI) is increasingly being used in cardiology to detect heart disease and guide therapy. It is mooted to be a safer alternative to imaging techniques, such as computed tomography (CT) or coronary angiographic imaging. However, there has recently been an increased interest in the potential long-term health risks of MRI, especially in the light of the controversy resulting from a small number of research studies reporting an increase in DNA damage following exposure, with calls to limit its use and avoid unnecessary examination, according to the precautionary principle. Overall the published data are somewhat limited and inconsistent; the ability of MRI to produce DNA lesions has yet to be robustly demonstrated and future experiments should be carefully designed to optimize sensitivity and benchmarked to validate and assess reproducibility. The majority of the current studies have focussed on the initial induction of DNA damage, and this has led to comparisons between the reported induction of γH2AX and implied double-strand break (DSB) yields produced following MRI with induction by imaging techniques using ionizing radiation. However, γH2AX is not only a marker of classical double-ended DSB, but also a marker of stalled replication forks and in certain circumstances stalled DNA transcription. Additionally, ionizing radiation is efficient at producing complex DNA damage, unique to ionizing radiation, with an associated reduction in repairability. Even if the fields associated with MRI are capable of producing DNA damage, the lesions produced will in general be simple, similar to those produced by endogenous processes. It is therefore inappropriate to try and infer cancer risk by simply comparing the yields of γH2AX foci or DNA lesions potentially produced by MRI to those produced by a given exposure of ionizing radiation, which will generally be more biologically effective and have a greater probability of leading to long-term health effects. As a result, it is important to concentrate on more relevant downstream end points (e.g. chromosome aberration production), along with potential mechanisms by which MRI may lead to DNA lesions. This could potentially involve a perturbation in homeostasis of oxidative stress, modifying the background rate of endogenous DNA damage induction. In summary, what the field needs at the moment is more research and less fear mongering.

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“…This would support why the authors found a delay between CMR exposure and DNA damage. The authors suggest that previous studies had found a somewhat earlier increase in DSB because patients were also exposed to gadolinium, 3,23 which has been shown to potentiate the genotoxic effect of CMR 30 but still requires some delay after CMR exposure.…”

Section: See Article By Lancellotti Et Almentioning

confidence: 84%

Cardiac Magnetic Resonance Imaging

Kaufmann

2015

Circ: Cardiovascular Imaging

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Impact of contrast enhanced MRI on lymphocyte DNA damage and serum visfatin level

Cited by 34 publications

References 35 publications

Impact of cardiac magnetic resonance imaging on human lymphocyte DNA integrity

Impact of cardiac magnetic resonance imaging on human lymphocyte DNA integrity

Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity

Cardiac Magnetic Resonance Imaging

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