Impact of conventional anesthesia on auditory brainstem responses in mice

Looij, Marjolein A.J. van; Liem, Su-San; Burg, H. van der; Wees, Jacqueline van der; Zeeuw, Chris I. De; Zanten, Bert G. A. van

doi:10.1016/j.heares.2004.02.009

Cited by 41 publications

(43 citation statements)

References 23 publications

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“…These results are similar to those reported for mice showing that ABR thresholds are significantly lower in the awake than in the ketamine/xylazine anesthetized condition (difference of 8.0 ± 1.8 dB) [19]. In contrast varying isoflurane levels in geckos and anoles reveals little effect on the ABR.…”

Section: Discussionsupporting

confidence: 90%

Effect of the Level of Anesthesia on the Auditory Brainstem Response in the Emei Music Frog (Babina daunchina)

et al. 2017

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Anesthesia is known to affect the auditory brainstem response (ABR) in mice, rats, birds and lizards. The present study investigated how the level of anesthesia affects ABR recordings in an amphibian species, Babina daunchina. To do this, we compared ABRs evoked by tone pip stimuli recorded from 35 frogs when Tricaine methane sulphonate (MS-222) anesthetic immersion times varied from 0, 5 and 10 minutes after anesthesia induction at sound frequencies between 0.5 and 6 kHz. ABR thresholds increased significantly with immersion time across the 0.5 kHz to 2.5 kHz frequency range, which is the most sensitive frequency range for hearing and the main frequency range of male calls. There were no significant differences for anesthetic levels across the 3 kHz to 6 kHz range. ABR latency was significantly longer in the 10 min group than in the 0 and 5 min groups at frequencies of 0.5, 1.0, 1.5, 2.5 kHz, while ABR latency did not differ across the 3 kHz to 4 kHz range and at 2.0 kHz. Taken together, these results show that the level of anesthesia affects the amplitude, threshold and latency of ABRs in frogs.

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Section: Discussionsupporting

confidence: 90%

Effect of the Level of Anesthesia on the Auditory Brainstem Response in the Emei Music Frog (Babina daunchina)

et al. 2017

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“…Before surgery, the auditory brainstem response (ABR) was measured to obtain hearing thresholds in 17 animals at 4, 8, 16, and 32 kHz, as described previously (van Looij et al, 2004). Rats were anesthetized with ketamine/xylazine (0.08 ml/10 g body weight of a solution containing 0.12% xylazine and 0.8% ketamine in 0.9% NaCl).…”

Section: Methodsmentioning

confidence: 99%

Developmental Changes in Short-Term Plasticity at the Rat Calyx of Held Synapse

Crins¹,

Rusu²,

Rodríguez-Contreras³

et al. 2011

J. Neurosci.

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The calyx of Held synapse of the medial nucleus of the trapezoid body functions as a relay synapse in the auditory brainstem. In vivo recordings have shown that this synapse displays low release probability and that the average size of synaptic potentials does not depend on recent history. We used a ventral approach to make in vivo extracellular recordings from the calyx of Held synapse in rats aged postnatal day 4 (P4) to P29 to study the developmental changes that allow this synapse to function as a relay. Between P4 and P8, we observed evidence for the presence of large short-term depression, which was counteracted by short-term facilitation at short intervals. Major changes occurred in the last few days before the onset of hearing for air-borne sounds, which happened at P13. The bursting pattern changed into a primary-like pattern, the amount of depression and facilitation decreased strongly, and the decay of facilitation became much faster. Whereas short-term plasticity was the most important cause of variability in the size of the synaptic potentials in immature animals, its role became minor around hearing onset and afterward. Similar developmental changes were observed during stimulation experiments both in brain slices and in vivo following cochlear ablation. Our data suggest that the strong reduction in release probability and the speedup of the decay of synaptic facilitation that happen just before hearing onset are important events in the transformation of the calyx of Held synapse into an auditory relay synapse.

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“…Previous in-vivo studies of SPON physiology were conducted under ketamine anesthesia (Behrend et al, 2002; Dehmel et al, 2002; Kulesza Jr. et al, 2003; 2007; Kadner et al, 2006; Kadner and Berrebi, 2008), which is known to alter brainstem auditory evoked potentials, resulting in higher peak latencies (Church and Gritzke, 1987; Smith and Mills, 1989; 1991) and elevated thresholds (van Looij et al, 2004). Both of these effects are thought to be mediated by antagonism of the N-methyl-D-aspartate glutamate receptor (NMDAR; Anis et al, 1983; Harrison and Simmonds, 1985).…”

Section: Introductionmentioning

confidence: 99%

Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

2012

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The superior paraolivary nucleus (SPON; alternative abbreviation: SPN for the same nucleus in certain species) is a prominent brainstem structure that provides strong inhibitory input to the auditory midbrain. Previous studies established that SPON neurons encode temporal sound features with high precision. These earlier characterizations of SPON responses were recorded under the influence of ketamine, a dissociative anesthetic agent and known antagonist of NMDA receptors. Because NMDA alters neural responses from the auditory brainstem, single unit extracellular recordings of SPON neurons were performed in the presence and absence of ketamine. In doing so, this study represents the first in-vivo examination of the SPON of the mouse. Herein, independent data sets of SPON neurons are characterized that did or did not receive ketamine, as well as neurons that were recorded both prior to and following ketamine administration. In all conditions, SPON neurons exhibited contralaterally-driven spikes triggered by the offset of pure tone stimuli. Ketamine lowered both evoked and spontaneous spiking, decreased the sharpness of frequency tuning and increased auditory thresholds and first-spike latencies. In addition, ketamine limited the range of modulation frequencies to which neurons phase-locked to sinusoidally amplitude-modulated tones.

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Impact of conventional anesthesia on auditory brainstem responses in mice

Cited by 41 publications

References 23 publications

Effect of the Level of Anesthesia on the Auditory Brainstem Response in the Emei Music Frog (Babina daunchina)

Effect of the Level of Anesthesia on the Auditory Brainstem Response in the Emei Music Frog (Babina daunchina)

Developmental Changes in Short-Term Plasticity at the Rat Calyx of Held Synapse

Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse

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